Home › Research › Down syndrome and Alzheimer's
Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis
Huang T, Lam XJ, Lim CT, Jusoh N, Fakurazi S, Cheah PS, Ling KH.. Journal of intellectual disabilities : JOID, 2024-11-13
Topic: Brain proteins, microglia and lab models
Down syndrome (DS), characterised by compromised brain development and intellectual challenges, often manifests Alzheimer's disease (AD) -like symptoms. Utilising the Web of Science Core Collection (WOSCC) database from January 1, 2000, to July 31, 2023, we conducted a comprehensive bibliometric analysis using VOSviewer, CiteSpace, and the R package "bibliometrix." Analyses included co-authorship, co-citation, co-occurrence, cooperative network, reference, and keyword burst citation. Analysing 5,082 papers, the U.S. demonstrated prominence with the highest number of research organisations and citations. Keyword analysis revealed promising research areas, including "Alzheimer's disease," "development," "inflammation," and "neurogenesis". This 22-year survey of the brain with trisomy 21 research unveils key trends, contributors, and focal areas in DS neuropathogenesis. Notably, Alzheimer 's-related genes and proteins play a pervasive role in DS neuropathological processes across patients' lifespans. The study contributes foundational knowledge for advancing research and care in the DS neuropathogenesis domain.
Key findings
- Analysing 5,082 papers, the U.S. demonstrated prominence with the highest number of research organisations and citations.
- Keyword analysis revealed promising research areas, including "Alzheimer's disease," "development," "inflammation," and "neurogenesis".
Why it matters
This bibliometric analysis of 5,082 papers maps research trends on Down syndrome neuropathogenesis, noting Alzheimer's-related genes and proteins as a pervasive theme. It is a survey of publications and provides no treatment, cure or prevention findings.
Study details
- Evidence strengthLow
How this study scored 30/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of intellectual disabilities : JOID) |
| Journal's citation record | 0 / 4 | Journal of Intellectual Disabilities: journal h-index 51 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.8 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 2 / 6 | Cited 1.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author King‐Hwa Ling: h-index 31 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universiti Putra Malaysia: institution h-index 477 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39533897) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 30 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1177/17446295241299160
- PubMed: 39533897
- Original source →
- Free full text: Journal of Intellectual Disabilities →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Huang, T., Lam, X. J., Lim, C. T., Jusoh, N., Fakurazi, S., Cheah, P. S., et al. (2024). Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis. Journal of intellectual disabilities : JOID. https://doi.org/10.1177/17446295241299160
Vancouver
Huang T, Lam XJ, Lim CT, Jusoh N, Fakurazi S, Cheah PS, et al. Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis. Journal of intellectual disabilities : JOID. 2024. doi:10.1177/17446295241299160. PMID: 39533897.
BibTeX
@article{huang2024-39533897,
author = {Huang, T. and Lam, X. J. and Lim, C. T. and Jusoh, N. and Fakurazi, S. and Cheah, P. S. and Ling, K. H.},
title = {{Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis}},
journal = {Journal of intellectual disabilities : JOID},
year = {2024},
doi = {10.1177/17446295241299160},
pmid = {39533897},
url = {https://doi.org/10.1177/17446295241299160}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Down syndrome and Alzheimer's
Also tagged “down”
527 studies in the library carry the topic tag “down”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 527 tagged studies.