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Home › Research › Brain scans and imaging

Cerebral perfusion and amyloidosis in the oldest-old

Shubir Dutt, Davis C Woodworth, S Ahmad Sajjadi, Dana E Greenia, Charles DeCarli, Claudia H Kawas, María M Corrada, Daniel A Nation. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024-11-13

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Brain scans and imaging

Topic: Plasma and spinal-fluid biomarkers

Participants with CIND displayed lower perfusion in the PCC+PCu relative to participants who were CN, but there was no statistically significant difference between the groups in amyloid burden in this region. In addition, participants with CIND exhibited lower inferior parietal and higher orbitofrontal perfusion. Cerebral perfusion is related to cognitive status in the oldest-old independent of amyloidosis. HIGHLIGHTS: Cerebral perfusion and amyloid positron emission tomography (PET) were measured in older adults: 90 years of age and older. Perfusion but not amyloid differed between cognitively impaired and normal groups. Frontal and parietal regions linked to cognitive decline had altered perfusion. Perfusion is related to cognitive status in the oldest-old independent of amyloid.

Key findings

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Study details

How this study scored 70/100
How this study's score is builtJournal tier 9 of 10; Journal's citation record left out, no data; Study design 6 of 12; Strength of evidence 3 of 5; Peer-review validation 10 of 10; How recent 4 of 5; Sample size 2 of 4; Effect reported 0 of 3; Studied in people 3 of 3; Randomised / blinded 0 of 2; Times cited left out, no data; Citations per year left out, no data; Impact for its field and year left out, no data; Cited by studies here left out, no data; Still being cited left out, no data; Senior author's track record left out, no data; Institution's track record left out, no data; Multi-centre collaboration left out, no data; Indexed in PubMed 2 of 2; Free to read left out, no data. 39 of the 56 points it could be judged on, which is 70 of 100. Total 70 of 100.39 of the 56 points we could judge = 70 of 100

Published in a leading specialty journal, and it is a case-control study. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.

ComponentPointsWhy
Journal tier 9 / 10 Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association)
Journal's citation record — / 4 No journal record from OpenAlex — left out of this score
Study design 6 / 12 A case-control study
Strength of evidence 3 / 5 Rated “moderate” in our summary
Peer-review validation 10 / 10 Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent 4 / 5 2024 — within 3 year(s) of the newest study here
Sample size 2 / 4 113 participants
Effect reported 0 / 3 No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people 3 / 3 Studied in people (participant count stated)
Randomised / blinded 0 / 2 No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited — / 7 No citation count (not found in OpenAlex) — left out of this score
Citations per year — / 5 No citation count or no year — left out of this score
Impact for its field and year — / 6 No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here — / 6 Not yet checked against this library's citation graph — left out of this score
Still being cited — / 4 No yearly citation counts — left out of this score
Senior author's track record — / 4 Senior author's record not available — left out of this score
Institution's track record — / 3 No institution listed in OpenAlex — left out of this score
Multi-centre collaboration — / 3 Institutions not listed — left out of this score
Indexed in PubMed 2 / 2 Indexed in PubMed (PMID 39535349)
Free to read — / 2 Access not recorded — left out of this score
Points 39 / 56 Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100.
Total 70 / 100 —

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Dutt, S., Woodworth, D. C., Sajjadi, S. A., Greenia, D. E., DeCarli, C., Kawas, C. H., et al. (2024). Cerebral perfusion and amyloidosis in the oldest-old. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.14357

Vancouver

Dutt S, Woodworth DC, Sajjadi SA, Greenia DE, DeCarli C, Kawas CH, et al. Cerebral perfusion and amyloidosis in the oldest-old. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024. doi:10.1002/alz.14357. PMID: 39535349.

BibTeX

@article{dutt2024-39535349,
  author  = {Dutt, Shubir and Woodworth, Davis C and Sajjadi, S Ahmad and Greenia, Dana E and DeCarli, Charles and Kawas, Claudia H and Corrada, María M and Nation, Daniel A},
  title   = {{Cerebral perfusion and amyloidosis in the oldest-old}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2024},
  doi     = {10.1002/alz.14357},
  pmid    = {39535349},
  url     = {https://doi.org/10.1002/alz.14357}
}

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