Newest studies

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: Moreover, expression of a constitutively active IRF3 (S388D/S390D: IRF3-2D) in microglia induces a transcriptional program reminiscent of the Activated Response Microglia and the expression of genes associated with Alzheimer's disease, notably apolipoprotein-e. +1 more finding

• Brain Biology
• Genetics

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Association between air pollution and cerebrospinal fluid alpha-synuclein in urban elders: the CABLE study

52/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: We found a significant correlation of CSF α-syn level with PM2.5 in urban participants. +3 more findings

• Risk Factors
• Biomarkers

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The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice

43/100 ✓ Peer-reviewed Drug development Molecular metabolism

Key finding: Semaglutide reduced body weight and improved glucose tolerance in 12-month-old male and female 5XFAD and APP/PS1 mice, consistent with pharmacological engagement of the GLP-1R. +4 more findings

• Treatments
• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab

53/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our case suggests that ischemic strokes may be a feature of ARIA and highlights the importance of having a high clinical suspicion for seizures in ARIA. +4 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

End-of-life experiences in individuals with dementia with Lewy bodies and their caregivers: A mixed-methods analysis

50/100 ✓ Peer-reviewed End-of-life care PloS one

Key finding: Individuals with DLB (n = 50) died 3.24 ± 1.81 years after diagnosis, typically of disease-related complications. +4 more findings

• End-of-Life Care
• Other Dementias
• Caregiving

Full summary, score breakdown and related studies → Original source

Population pharmacokinetics and exposure-response analyses of safety (ARIA-E and isolated ARIA-H) of lecanemab in subjects with early Alzheimer's disease

55/100 ✓ Peer-reviewed Treatments CPT: pharmacometrics & systems pharmacology

Key finding: Importantly, age, a well-recognized risk factor for AD, was not found to significantly affect lecanemab PK. +2 more findings

• Treatments
• Side Effects

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Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia

69/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: EEG abnormalities have the potential as neural biomarkers to identify neurological complications at the early stage of the disease, to assist clinical assessment, and to assess cognitive decline risk in Long COVID patients. +4 more findings

• Brain Biology

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CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders

56/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: We tested the CSF of 40 patients with CBS (19 female patients, 65.9 ± 8.6 years) and 28 with PSP (13 female patients, 72.5 ± 8.7 years old), mostly White (n = 50) or Asian (n = 14). αSyn-SAA positivity was observed in 35.9% patients with CBS and 28.6% with PSP. +2 more findings

• Biomarkers

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APOE4-related differences in cortical thickness are modulated by sex in middle age

43/100 ✓ Peer-reviewed Genetics Brain imaging and behavior

Key finding: Compared to males, females had thicker superior frontal cortices bilaterally, left middle temporal cortex, and left pars triangularis. +4 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Cellular communities reveal trajectories of brain ageing and Alzheimer's disease

60/100 ✓ Peer-reviewed Inflammation and the immune system Nature

Key finding: Here we used a data-driven approach to reconstruct the dynamics of the brain's cellular environment and identified a trajectory leading to AD that is distinct from other ageing-related effects. +3 more findings

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Sodium-Glucose Cotransporter-2 Inhibitors, Dulaglutide, and Risk for Dementia : A Population-Based Cohort Study

63/100 ✓ Peer-reviewed Drug development Annals of internal medicine

Key finding: Overall, 12 489 patients initiating SGLT2 inhibitor treatment (51.9% dapagliflozin and 48.1% empagliflozin) and 1075 patients initiating dulaglutide treatment were included. +4 more findings

• Treatments

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Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Cells

Key finding: Most clinical trials targeting the classical hallmarks of this disease-β-amyloid plaques and neurofibrillary tangles-failed, showed discrete clinical effects, or were accompanied by concerning side effects. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Global Public Health Implications of Traffic Related Air Pollution: Systematic Review

54/100 ✓ Peer-reviewed Risk factors Environmental health insights

Key finding: In this study, 1 282 032 participants ranging from 19 to 452 735 were included in 30 articles published from 2010 to 2022. +4 more findings

• Risk Factors

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The association between sleep and Alzheimer's disease: a systematic review

43/100 ✓ Peer-reviewed Risk factors Dementia & neuropsychologia

Key finding: Studies suggest that individuals who experience memory loss may encounter sleep disturbances before noticing other symptoms. +4 more findings

• Lifestyle

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Color Fundus Photography and Deep Learning Applications in Alzheimer Disease

46/100 ✓ Peer-reviewed Brain scans and imaging Mayo Clinic proceedings. Digital health

Key finding: The self-supervised ADRET model had superior accuracy when compared with ADVAS, in both UK Biobank (98.27% vs 77.20%; P<.001) and our institutional testing data sets (98.90% vs 94.17%; P=.04). +4 more findings

• Digital Tools

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Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

70/100 ✓ Peer-reviewed Disparities Nature medicine

Key finding: LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. +3 more findings

• Health Equity

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Improving genetic risk modeling of dementia from real-world data in underrepresented populations

55/100 ✓ Peer-reviewed Disparities Communications biology

Key finding: Genetic risk modeling for dementia offers significant benefits, but studies based on real-world data, particularly for underrepresented populations, are limited. +2 more findings

• Health Equity
• Genetics

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Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

45/100 ✓ Peer-reviewed Treatments Signal transduction and targeted therapy

Key finding: Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges.

• Treatments
• Clinical Trials
• Side Effects

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Geographic disparities in Alzheimer's disease and related dementia mortality in the US: Comparing impacts of place of birth and place of residence

50/100 ✓ Peer-reviewed Risk factors SSM - Population Health

Key finding: We found that both state of birth and state of residence account for a modest portion of ADRD mortality variation. +4 more findings

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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

61/100 ✓ Peer-reviewed Inflammation and the immune system Science (New York, N.Y.)

Key finding: We report that inhibition of indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN), rescues hippocampal memory function in mouse preclinical models of AD by restoring astrocyte metabolism. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study

64/100 ✓ Peer-reviewed Treatments Alzheimer's & Dementia

Key finding: Our findings illuminate the potential benefits of ChEI treatment in DLB patients. +3 more findings

• Treatments
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Effect of long-term physical exercise and multidomain interventions on cognitive function and the risk of mild cognitive impairment and dementia in older adults: A systematic review with meta-analysis

89/100 ✓ Peer-reviewed Prevention trials Ageing research reviews

Key finding: Sixteen trials, including 11,402 participants (mean age 73.2 [±5.5] years; 62.3 % female) were examined. +4 more findings

• Early Stage
• Lifestyle

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Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends

43/100 ✓ Peer-reviewed Brain scans and imaging Progress in retinal and eye research

Key finding: Alzheimer's disease (AD) is the leading cause of dementia worldwide. +3 more findings

• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Digital Cognitive Test for Early Detection of Dementia

43/100 ✓ Peer-reviewed Cognitive tests and assessment Studies in health technology and informatics

Key finding: Dementia poses a significant global health problem, necessitating early detection for effective intervention.

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Diagnostic accuracy of automated Lumipulse plasma pTau-217 in Alzheimer's disease: a real-world study

61/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: The CSF A/T profiles included 49 A+/T+, 8 A+/T-, and 41 A-/T-. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source