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Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation
Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali, Enise I Incesoy, Jose Bernal, Hartmut Schütze, Renat Yakupov et al.. Nature communications, 2024-11-13
Topic: Brain imaging, connectivity and assessment
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate moderation analysis, we identify a CR-related activity pattern underlying successful memory encoding that moderates the detrimental effect of AD pathological load on cognitive performance. CR is mainly represented by a more pronounced expression of the task-active network encompassing deactivation of the default mode network (DMN) and activation of inferior temporal regions including the fusiform gyrus. We devise personalized fMRI-based CR scores that moderate the impact of AD pathology on cognitive performance and are positively associated with years of education. Furthermore, higher CR scores attenuate the effect of AD pathology on cognitive decline over time. Our findings primarily provide evidence for the maintenance of core cognitive circuits including the DMN as the neural basis of CR. Individual brain activity levels of these areas during memory encoding have prognostic value for future cognitive decline.
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APA 7th
Vockert, N., Machts, J., Kleineidam, L., Nemali, A., Incesoy, E. I., Bernal, J., et al. (2024). Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation. Nature communications. https://doi.org/10.1038/s41467-024-53360-9
Vancouver
Vockert N, Machts J, Kleineidam L, Nemali A, Incesoy EI, Bernal J, et al. Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation. Nature communications. 2024. doi:10.1038/s41467-024-53360-9. PMID: 39537609.
BibTeX
@article{vockert2024-39537609,
author = {Vockert, Niklas and Machts, Judith and Kleineidam, Luca and Nemali, Aditya and Incesoy, Enise I and Bernal, Jose and Schütze, Hartmut and Yakupov, Renat and others},
title = {{Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation}},
journal = {Nature communications},
year = {2024},
doi = {10.1038/s41467-024-53360-9},
pmid = {39537609},
url = {https://doi.org/10.1038/s41467-024-53360-9}
}
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Key findings
- The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration.
- We devise personalized fMRI-based CR scores that moderate the impact of AD pathology on cognitive performance and are positively associated with years of education.
- Our findings primarily provide evidence for the maintenance of core cognitive circuits including the DMN as the neural basis of CR.
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Study details
- Study designlongitudinal study
- Participants490
- Evidence strengthModerate
How this study scored 71/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 42 of the 59 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 490 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39537609) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 42 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 42 of the 59 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
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