Newest studies

Pragmatic algorithm for visual assessment of 4-Repeat tauopathies in [18F]PI-2620 PET Scans

50/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Patients with 4R-tauopathies in contrast to non-4R-tauopathies were detected at higher sensitivity in the 20-40-minute frame (common: 79%, scaled: 76%) compared to the 40-60-minute frame (common: 55%, scaled: 62%), albeit with reduced specificity in the common setting (20-40-min: 78%, 40-60-min: 95%), which was ameliorated in the intensity-scaled setting (20-40-min: 91%, 40-60-min: 96%). +4 more findings

• Brain Scans

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Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease

43/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. +4 more findings

• Genetics

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Development and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study

40/100 ✓ Peer-reviewed Clinical safety JMIR Perioperative Medicine

Key finding: The study cohort included 7167 delirium cases and 7167 matched controls. +4 more findings

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Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study

47/100 ✓ Peer-reviewed Prevention trials Frontiers in Psychology

Key finding: These findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline. +3 more findings

• Clinical Trials
• Digital Tools
• Other Dementias

Full summary, score breakdown and related studies → Original source

Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

57/100 ✓ Peer-reviewed Inflammation and the immune system Annals of Neurology

Key finding: Analyses revealed significant nonlinear interaction effects of ELS severity and age on NfL and GFAP serum concentrations, total and subcortical gray matter volume loss, increased third ventricular volume, and cognitive impairment. +2 more findings

• Brain Biology

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Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia

41/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer s Research & Therapy

Key finding: 86.8% of patients in this cohort presented more than one pathology. +3 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia

35/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neurology

Key finding: Our studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher. +4 more findings

• Diagnosis

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The potential role of machine learning and deep learning in differential diagnosis of Alzheimer’s disease and FTD using imaging biomarkers: A review

40/100 ✓ Peer-reviewed Digital health tools The Neuroradiology Journal

Key finding: IntroductionThe prevalence of neurodegenerative diseases has significantly increased, necessitating a deeper understanding of their symptoms, diagnostic processes, and prevention strategies. +1 more finding

• Digital Tools
• Brain Scans
• Diagnosis

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Implementing Namaste Care in nursing care homes for people with advanced dementia: a systematically constructed review with framework synthesis

38/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: Twenty-five studies met the inclusion criteria. +4 more findings

• Caregiving
• Care Services

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Association of Medial Temporal Lobe Cerebrovascular Reactivity and Memory Function in Older Adults With and Without Cognitive Impairment

52/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Deficits in medial temporal CVR are observed in older adults with MCI and are related to worse memory function. +3 more findings

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Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia

64/100 ✓ Peer-reviewed Getting a diagnosis Brain

Key finding: Our findings revealed distinct patterns of connectivity linked to normal ageing or Alzheimer's disease. +2 more findings

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Ultra-processed food consumption and risk of dementia and Alzheimer's disease: The Framingham Heart Study

63/100 ✓ Peer-reviewed Prevention and risk The Journal of Prevention of Alzheimer s Disease

Key finding: The study sample included 1,375 participants free of dementia and stroke at baseline (mean age 68 ± 6y, 54 % females). +4 more findings

• Risk Factors

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Environmental factors inducing gastric cancer: insights into risk and prevention strategies

40/100 ✓ Peer-reviewed Prevention and risk Discover Oncology

Key finding: Gastric cancer, a prevalent malignant tumor worldwide, poses a significant challenge to global health. +1 more finding

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications

52/100 ✓ Peer-reviewed Prevention and risk Antioxidants

Key finding: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which is the leading cause of morbidity and mortality among diabetic patients.

• Risk Factors
• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Alzheimer disease: Mechanism and treatments

28/100 ✓ Peer-reviewed Treatments Theoretical and Natural Science

Key finding: There are also monoclonal antibody drugs that are more directly directed against plaques. +4 more findings

• Treatments

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Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer's Disease

43/100 ✓ Peer-reviewed Genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: While genome-wide association studies (GWAS) have revealed genomic variants linked to AD, their translational impact has been limited due to challenges in interpreting the identified genetic associations.

• Genetics

Full summary, score breakdown and related studies → Original source

Post-marketing safety concerns with lecanemab: a pharmacovigilance study based on the FDA Adverse Event Reporting System database

59/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Lecanemab may have a significant potential for AEs. +3 more findings

• Treatments
• Side Effects

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Alzheimer Disease Anti-Amyloid Immunotherapies: Imaging Recommendations and Practice Considerations for Monitoring of Amyloid-Related Imaging Abnormalities

41/100 ✓ Peer-reviewed Treatments AJNR. American journal of neuroradiology

Key finding: On the basis of consensus discussion within an expanded American Society of Neuroradiology (ASNR) Alzheimer, ARIA, and Dementia Study Group, our purpose is the following: 1) summarize the FDA guidelines for the evaluation of radiographic ARIA; 2) review the 3 key MRI sequences for ARIA monitoring and standardized imaging protocols on the basis of ASNR-industry collaborations; 3) provide imaging recommendations for 3 key patient scenarios; 4) highlight the role of the radiologist in the care team for this population; 5) discuss implementation of MRI protocols to detect ARIA in diverse practice settings; and 6) present the results of the 2023 ASNR international neuroradiologist practice survey on dementia and ARIA imaging.

• Treatments
• Side Effects
• Brain Scans

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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease

81/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

Key finding: Enrollment was undertaken between May 18, 2021, and September 8, 2023. +1 more finding

• Clinical Trials
• Treatments
• Side Effects

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Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET-A Decade of Post-Authorization Insights

35/100 ✓ Peer-reviewed Health systems and care delivery Pharmaceuticals (Basel, Switzerland)

Key finding: Initially, the clinical adoption of FBB PET faced significant barriers, including reimbursement challenges and uncertainties regarding its integration into diagnostic clinical practice.

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

A relational approach to co-create Advance Care Planning with and for people living with dementia: a narrative study

41/100 ✓ Peer-reviewed Caregiving BMC Palliative Care

Key finding: The Shifting Expectations narrative indicated that PwD's needs shifted to co-constructed needs with their family as PwD's independence declined. +4 more findings

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Understanding Challenges and Emotions of Informal Caregivers of General Older Adults and People With Alzheimer Disease and Related Dementia: Comparative Study

46/100 ✓ Peer-reviewed Caregiving Journal of Medical Internet Research

Key finding: In total, 3028 posts were retrieved, including 1552 from older adult-related subreddits and 1476 from Alzheimer disease-related subreddits; 18 key topics were identified, with the most frequent topics being expressing feelings (2178/3028, 71.93%) and seeking advice and support (1982/3028, 65.46%). +4 more findings

• Caregiving

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Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK

58/100 ✓ Peer-reviewed Prevention and risk Nature Communications

Key finding: Alcohol (relative risk per 20 g/day=1.15, 95% confidence interval 1.09-1.20) and calcium (per 300 mg/day=0.83, 0.77-0.89) intakes had the strongest associations, followed by six dairy-related factors associated with calcium. +2 more findings

• Lifestyle

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Development and Validation of a Tool to Predict Onset of Mild Cognitive Impairment and Alzheimer Dementia

57/100 ✓ Peer-reviewed Treatments JAMA Network Open

Key finding: Among the 1665 AIBL participants (741 [44.5%] female) and 2029 ADNI participants (925 [45.6%] female), the mean (SD) age at first evaluation was 71.8 (7.1) years and 74.5 (6.7) years, respectively. +4 more findings

• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders

61/100 ✓ Peer-reviewed Genetics JAMA Psychiatry

Key finding: Expression profiles of amacrine cells (interneurons within the retina) were robustly enriched in schizophrenia genetic risk across mammalian species and in different developmental stages. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source