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Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia
Yaping Wang, Mingyan Liu, Yaping Liu, Xiaowei Tang, Xiaowei Tang, Xiangming Tang, Xiangming Tang. Frontiers in Neurology, 2025-01-09
Topic: Risk, prevention and care in population studies
Our studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher. Furthermore, the risk stratification (high- and moderate-) of DC, DRs, and AC in VD and AD groups was increased, while the low-risk was simultaneously decreased. In addition, DC and DRs were positively while AC and Lp-PLA2 were negatively correlated with MMSE scores. Logistic regression analysis indicated that DC, DRs, AC, and Lp-PLA2 were associated with dementia. Moreover, the areas under the ROC curves showed that the combination of five variables and AC + Lp-PLA2 were 0.970 (95% CI, 0.923-0.992) and 0.940 (95% CI, 0.882-0.974) were larger than each single indicator alone. Distinctive alterations in dynamic electrocardiogram-related indicators reveal a decline in autonomic nervous functions among individuals with dementia. By incorporating comprehensive analyses of DC, DRs, AC, and Lp-PLA2 values, the specificity and sensitivity of dementia diagnosis can be significantly enhanced.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wang, Y., Liu, M., Liu, Y., Tang, X., & Tang, X. (2025). Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia. Frontiers in Neurology. https://doi.org/10.3389/fneur.2024.1438736
Vancouver
Wang Y, Liu M, Liu Y, Tang X, Tang X. Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia. Frontiers in Neurology. 2025. doi:10.3389/fneur.2024.1438736. PMID: 39850729.
BibTeX
@article{wang2025-39850729,
author = {Wang, Yaping and Liu, Mingyan and Liu, Yaping and Tang, Xiaowei and Tang, Xiangming},
title = {{Assessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia}},
journal = {Frontiers in Neurology},
year = {2025},
doi = {10.3389/fneur.2024.1438736},
pmid = {39850729},
url = {https://doi.org/10.3389/fneur.2024.1438736}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Our studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher.
- Furthermore, the risk stratification (high- and moderate-) of DC, DRs, and AC in VD and AD groups was increased, while the low-risk was simultaneously decreased.
- In addition, DC and DRs were positively while AC and Lp-PLA2 were negatively correlated with MMSE scores.
- Logistic regression analysis indicated that DC, DRs, AC, and Lp-PLA2 were associated with dementia.
- Moreover, the areas under the ROC curves showed that the combination of five variables and AC + Lp-PLA2 were 0.970 (95% CI, 0.923-0.992) and 0.940 (95% CI, 0.882-0.974) were larger than each single indicator alone.
Why it matters
This study found that heart rate deceleration capacity, deceleration runs, acceleration capacity, and lipoprotein-related phospholipase A2 were associated with dementia and correlated with MMSE scores. Combining these indicators improved the sensitivity and specificity of dementia diagnosis.
Study details
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 34 of the 96 points we could judge it on, which is 35 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Neurology) |
| Journal's citation record | 2 / 4 | Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 0 / 3 | Nanjing Medical University: institution h-index 508 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39850729) |
| Free to read | 2 / 2 | Free to read |
| Points | 34 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 34 of the 96 points we could judge it on is 35 out of 100. |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fneur.2024.1438736
- PubMed: 39850729
- Original source →
- Free full text: Frontiers in Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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