Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,101–18,125 of 27,380 studies, newest first · page 725 of 1096.
January 2014 25
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2014-01-17
Implications for Policy: The Nursing Home as Least Restrictive Setting
49/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist
Key finding: Measurement using validated tools for resident and family satisfaction and health outcomes showed that culture change interventions or clusters of interventions had few negative impacts, but also seldom resulted in statistically significant improvement. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-17
Depressive symptoms precede memory decline, but not vice versa, in non-demented older adults
58/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: These findings suggest that depressive symptoms precede memory decline, but not vice versa, in late life. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-16
Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease
48/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in neuroinformatics
Key finding: We conclude that the image registration package elastix was substantially accelerated, with nearly identical results to the non-optimized version.
Full summary, score breakdown and related studies → Original source
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2014-01-16
The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
36/100 ✓ Peer-reviewed Drug development Diabetes, obesity & metabolism
Key finding: GLP-1 receptors are also expressed in extra-pancreatic tissues and trial data suggest that GLP-1RAs also have effects beyond their glycaemic actions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-16
Respite Care for People With Dementia and Their Carers
65/100 ✓ Peer-reviewed Caregiving Cochrane Database of Systematic Reviews
Key finding: Only 4 randomized trials with 753 total participants met inclusion criteria; results could not be statistically pooled due to differences in design +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-15
Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels
41/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: CSF α-synuclein levels were higher in AD patients as compared with cognitively healthy controls (P=.019) and patients with synucleinopathies (P<.001). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-15
Microvascular network alterations in the retina of patients with Alzheimer's disease
62/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Patients with AD have altered microvascular network in the retina (narrower retinal venules and a sparser and more tortuous retinal vessels) compared with matched nondemented controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-15
Effect of TTP488 in patients with mild to moderate Alzheimer's disease
65/100 ✓ Peer-reviewed Cognitive tests and assessment BMC neurology
Key finding: A previous report describes decreased decline in ADAS-cog (delta = 3.1, p = 0.008 at 18 months, ANCOVA with multiple imputation), relative to placebo, following a 5 mg/day dose of TTP488. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-14
Human apolipoprotein e resequencing by proteomic analysis and its application to serotyping
41/100 ✓ Peer-reviewed Genetics PloS one
Key finding: The mean coverage of the amino acid sequence of full-length ApoE was 91.6% in the protein resequence. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-14
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
51/100 ✓ Peer-reviewed Brain tissue and pathology Journal of cell science
Key finding: Large TDP-43 aggregates that are decorated with degradation adaptor proteins are seen in the cytoplasm of remaining neurons in ALS and FTD patients post mortem. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-14
Non-neurological surgery and cerebrospinal fluid biomarkers for neuronal and astroglial integrity
42/100 ✓ Peer-reviewed Biomarkers Journal of neural transmission (Vienna, Austria : 1996)
Key finding: CSF T-tau concentrations increased significantly during and after surgery (p = 0.028) and were significantly correlated with the administered doses of bupivacaine. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-13
Structural brain changes associated with depressive symptoms in the elderly with Alzheimer's disease
42/100 ✓ Peer-reviewed Long-term cohort studies Journal of neurology, neurosurgery, and psychiatry
Key finding: Two independent cohorts were used in this study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-13
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications
48/100 ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry
Key finding: This study provides pathological validation that the new criteria assist with separating PPA cases with AD pathology into the new lv-PPA syndrome and found that a number of diagnostic clinical features (disinhibition, food preferences and naming) did not assist in discriminating the different FTD syndromes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-10
Florbetapir (18F) for brain amyloid positron emission tomography: highlights on the European marketing approval
41/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This capability of florbetapir (18F) is regarded as a significant improvement in the diagnostic procedures for adult patients with cognitive impairment who are being evaluated for AD and other causes of cognitive impairment.
Full summary, score breakdown and related studies → Original source
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2014-01-10
Gender and incidence of dementia in the Framingham Heart Study from mid-adult life
60/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Selective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.
Full summary, score breakdown and related studies → Original source
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2014-01-10
The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese
55/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The prevalences of overall MCI, MCI-A, MCI-CVD, MCI-VRF, and MCI-O were 20.8% (95% confidence interval [CI] = 20.0-21.6%), 6.1% (95% CI = 5.7-6.6%), 3.8% (95% CI = 3.4-4.2%), 4.9% (95% CI = 4.5-5.4%), and 5.9% (95% CI = 5.5-6.4%) respectively. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-01-10
Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
57/100 ✓ Peer-reviewed Caregiving Acta neuropathologica
Key finding: We observed four patterns indicative of potentially sequential dissemination of pTDP-43: cases with the lowest burden of pathology (pattern I) were characterized by widespread pTDP-43 lesions in the orbital gyri, gyrus rectus, and amygdala.
Full summary, score breakdown and related studies → Original source
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2014-01-10
Future directions in Alzheimer's disease from risk factors to prevention
52/100 ✓ Peer-reviewed Prevention and risk Biochemical pharmacology
Key finding: Risk scores can help to identify high-risk individuals who might benefit from different interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-09
Is synaptic loss a unique hallmark of Alzheimer's disease?
36/100 ✓ Peer-reviewed Disease mechanisms Biochemical pharmacology
Key finding: These findings indicate that synapse loss is probably not a hallmark specific to AD but rather a change common to many diseases associated with dementia.
Full summary, score breakdown and related studies → Original source
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2014-01-09
Association of hearing impairment with brain volume changes in older adults
64/100 ✓ Peer-reviewed Digital health tools NeuroImage
Key finding: Whether peripheral hearing impairment is associated with accelerated rates of brain atrophy is unclear. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-09
Immunotherapy for Alzheimer's disease
41/100 ✓ Peer-reviewed Disparities Biochemical pharmacology
Key finding: Among the more exciting and advanced of these approaches is vaccination. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-08
Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death
40/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration
Key finding: An early substantial loss of basal forebrain cholinergic neurons (BFCNs) is a constant feature of Alzheimer's disease (AD) and is associated with deficits in spatial learning and memory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-08
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors
40/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: Thus, we generated induced pluripotent stem cells (iPSCs) from affected and unaffected individuals from two families carrying PSEN1 mutations. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-01-08
Prevalence and characteristics of patients with advanced chronic conditions in need of palliative care in the general population: a cross-sectional study
55/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Direct measurement of prevalence of palliative care needs on a population basis is feasible.
Full summary, score breakdown and related studies → Original source
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2014-01-08
Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences
54/100 ✓ Peer-reviewed Prevention and risk Clinical epidemiology
Key finding: While men may have a higher risk of mild cognitive impairment (MCI), an intermediate stage between normal aging and dementia, women are disproportionally affected with AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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