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Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia
Léa Chauveau, Brigitte Landeau, Sophie Dautricourt, Anne‐Laure Turpin, Marion Delarue, Oriane Hébert, Vincent de La Sayette, Gaël Chételat et al.. Brain, 2025-01-09
Topic: Amyloid, tau and blood-test diagnosis
Our findings revealed distinct patterns of connectivity linked to normal ageing or Alzheimer's disease. Advancing age throughout adulthood was associated with lower PM connectivity and more subtle changes in AT connectivity, and Alzheimer's disease was characterized by AT hyperconnectivity without global changes in PM connectivity. Specifically, AT connectivity was higher in MCI and Alzheimer-dementia patients compared with older controls and was positively associated with amyloid burden, glucose hypometabolism, hippocampal atrophy and global cognitive deficits in older adults, ranging from unimpaired to demented.
Key findings
- Our findings revealed distinct patterns of connectivity linked to normal ageing or Alzheimer's disease.
- Advancing age throughout adulthood was associated with lower PM connectivity and more subtle changes in AT connectivity, and Alzheimer's disease was characterized by AT hyperconnectivity without global changes in PM connectivity.
- Specifically, AT connectivity was higher in MCI and Alzheimer-dementia patients compared with older controls and was positively associated with amyloid burden, glucose hypometabolism, hippocampal atrophy and global cognitive deficits in older adults, ranging from unimpaired to demented.
Why it matters
This longitudinal study found that Alzheimer's disease was characterised by hyperconnectivity in the anterior-temporal network, which was associated with amyloid burden, glucose hypometabolism, hippocampal atrophy and cognitive deficits. It describes a pattern of brain connectivity and does not test any treatment, cure or prevention.
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Study details
- Study designlongitudinal study
- Participants209
- Evidence strengthModerate
How this study scored 64/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain) |
| Journal's citation record | 4 / 4 | Brain: journal h-index 503 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 209 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 25 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 15.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Robin de Florès: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39813142) |
| Free to read | 2 / 2 | Free to read |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Chauveau, L., Landeau, B., Dautricourt, S., Turpin, A., Delarue, M., Hébert, O., et al. (2025). Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia. Brain. https://doi.org/10.1093/brain/awaf008
Vancouver
Chauveau L, Landeau B, Dautricourt S, Turpin A, Delarue M, Hébert O, et al. Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia. Brain. 2025. doi:10.1093/brain/awaf008. PMID: 39813142.
BibTeX
@article{chauveau2025-39813142,
author = {Chauveau, Léa and Landeau, Brigitte and Dautricourt, Sophie and Turpin, Anne‐Laure and Delarue, Marion and Hébert, Oriane and de La Sayette, Vincent and Chételat, Gaël and others},
title = {{Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia}},
journal = {Brain},
year = {2025},
doi = {10.1093/brain/awaf008},
pmid = {39813142},
url = {https://doi.org/10.1093/brain/awaf008}
}
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