Newest studies

Association Between Cerebral Amyloid Angiopathy and Nontraumatic Subdural Hemorrhage

56/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: Among 8.5 million hospitalized patients aged 50 years or older, 2,335 had CAA and 600,646 had other CVDs. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration

48/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurodegeneration

Key finding: These studies have produced conflicting results: suggesting incongruously that TDP-43 phosphorylation may either drive disease progression or serve a neuroprotective role. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study

52/100 ✓ Peer-reviewed Cognitive tests and assessment International Psychogeriatrics

Key finding: In 893 participants with average age 93 years (range 90-102), 43 % had SMC. +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Biomarcadores para diagnóstico e prognóstico de doenças neurodegenerativas: uma revisão de literatura

27/100 ✓ Peer-reviewed Tau biomarkers Revista de Medicina

Key finding: Resultados: A combinação de medições de A?42, Tau e p-Tau, junto com novos biomarcadores plasmáticos, como p-Tau181 e NfL, oferece potencial para diagnósticos mais precoces e precisos na DA. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Impact of vitamin A on aged people’s cognition and Alzheimer’s disease progression in an animal model

47/100 ✓ Peer-reviewed Mild cognitive impairment npj Science of Food

Key finding: In the population-based study, information from 1817 adults aged 50 years and above was used for data analysis, and we found that subjects with plasma VA level greater than 0.539 μg/ml displayed a lower risk of mild cognitive impairment (MCI). +1 more finding

• Lifestyle
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Artificial intelligence and omics-based autoantibody profiling in dementia

50/100 ✓ Peer-reviewed Digital health tools Frontiers in Immunology

Key finding: PWAbS revealed elevated gross autoantibody levels in AD and DLB patients compared to CNIs. +4 more findings

• Digital Tools

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Integrative Strategies for Preventing and Managing Metabolic Syndrome: The Impact of Exercise and Diet on Oxidative Stress Reduction—A Review

40/100 ✓ Peer-reviewed Prevention and risk Life

Key finding: Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, hypertension, dyslipidemia, and chronic inflammation, significantly increasing the risk of cardiovascular disease and type 2 diabetes.

• Lifestyle
• Prevention
• Brain Biology

Full summary, score breakdown and related studies → Original source

Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study

44/100 ✓ Peer-reviewed Genetics Aging

Key finding: After adjusting for confounding factors, the ApoE ε4 allele was not associated with the risk of PSCI at 3 or 12 months post-stroke. +3 more findings

• Genetics
• Diagnosis

Full summary, score breakdown and related studies → Original source

The roles of microglia and astrocytes in neuroinflammation of Alzheimer's disease

43/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience

Key finding: It is hypothesized that targeting these molecular mechanisms associated with neuroinflammation and controlling risk factors may provide a viable therapeutic approach for AD.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Disease and Race‐Based Differences in Inpatient Palliative Care Consultation in Cancer and Noncancer Serious Illnesses

53/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Among 40,074 inpatient encounters (median age 72 years [IQR 62-82], 46.9% male, 22.7% Black, 4.6% Hispanic), the most common serious illness was heart failure (66.0%), followed by COPD (39.3%), kidney failure (12.4%), cancer (12.3%), and dementia (11.6%). +4 more findings

• End-of-Life Care
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Palliative Care for People With Very Severe to Extreme Behavioural and Psychological Symptoms of Dementia ( BPSD ): A Scoping Review

37/100 ✓ Peer-reviewed End-of-life care Journal of Advanced Nursing

Key finding: This review included six articles, and nine categories emerged from the findings. +4 more findings

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

A Scoping Review of the Effect and Experience of Participating in Dementia Rehabilitation When Living With Early Stage Dementia: Seen From a Lifelong Learning Perspective

27/100 ✓ Peer-reviewed Prevention trials Western Journal of Nursing Research

Key finding: Eligible studies used many study designs with different sample sizes. +4 more findings

Full summary, score breakdown and related studies → Original source

Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis

53/100 ✓ Peer-reviewed Prevention trials Gut

Key finding: Both the Keto and ADF groups demonstrated significant weight loss, but cognitive performance improved most notably in the ADF group, in association with reduced inflammation. +4 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences

42/100 ✓ Peer-reviewed Disease mechanisms Acta Neuropathologica Communications

Key finding: We identified several significant sex-specific and sex-dimorphic differentially expressed genes in neurons, microglia, astrocytes and oligodendrocytes, including both cross-sectional changes and alterations from 7 months to 17 months of age. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease

45/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer s Research & Therapy

Key finding: Functional studies demonstrated that SorLA deficiency results in increased production of Aβ peptide, and thus a higher risk of AD. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

A systematic analysis for disease burden, risk factors, and trend projection of Alzheimer’s disease and other dementias in China and globally

46/100 ✓ Peer-reviewed How common it is PLoS ONE

Key finding: The disease burden of ADD in China is heavier than in most countries and regions. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cognitive Assessment of Dementia in Incarcerated Populations: The Utility of the Addenbrooke’s Cognitive Examination 3rd Edition and the Mini-Addenbrooke’s Cognitive Examination

35/100 ✓ Peer-reviewed Getting a diagnosis Journal of Correctional Health Care

Key finding: Scores were compared with the psychogeriatrician's review to determine concordance rates. +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention

43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular and infection microbiology

Key finding: Moreover, the gut microbiome assumes a pivotal function in regulating the immune system, whereby dysbiosis is implicated in developing immunological-related ailments, including allergies and autoimmune disorders. +4 more findings

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Oral PRI-002 treatment in patients with MCI or mild AD: a randomized, double-blind phase 1b trial

84/100 ✓ Peer-reviewed Treatments Nature communications

Key finding: Overall, the study drug was well tolerated. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Biomarker advancements in cerebral small vessel disease: An overview

31/100 ✓ Peer-reviewed Vascular contributions Neural Regeneration Research

Key finding: Traditionally, its diagnosis has relied primarily on neuroimaging findings. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

39/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Disease

Key finding: These effects are dependent on interleukin-1 (IL-1) receptor activity and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and are associated with the formation of cytoplasmic stress granules. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Emotional Recognition: A Comparative Study of People with Mild Cognitive Impairment and Alzheimer’s Disease Self-Report with Caregiver Perspectives

37/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Geriatric Psychiatry and Neurology

Key finding: Participants across all groups showed significant differences in cognition and functionality. +4 more findings

• Early Stage
• Caregiving

Full summary, score breakdown and related studies → Original source

Autism and Dementia: A Summative Report from the 2nd International Summit on Intellectual Disabilities and Dementia

43/100 ✓ Peer-reviewed How common it is Journal of Autism and Developmental Disorders

Key finding: A review of current literature indicates a lack of comprehensive information on the demographics and factors associated with aging in autistic adults. +1 more finding

Full summary, score breakdown and related studies → Original source

Residential exposure to road and railway traffic noise and incidence of dementia: The UK Biobank cohort study

63/100 ✓ Peer-reviewed How common it is Environmental Research

Key finding: Distinct associations between different traffic noise exposures and incident dementia subtypes were found in this large UK prospective cohort study. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

MINDSETS: Multi-omics Integration with Neuroimaging for Dementia Subtyping and Effective Temporal Study

51/100 ✓ Peer-reviewed Getting a diagnosis Scientific Reports

Key finding: The crux of effective treatment in slowing neurodegeneration lies in early, accurate diagnosis, as this significantly assists doctors in determining the appropriate course of action.

• Brain Scans

Full summary, score breakdown and related studies → Original source