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Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia
Diana Ortega‐Cruz, Alberto Rábano, Bryan Andrew Strange. Alzheimer s Research & Therapy, 2025-01-09
Topic: Amyloid, tau and blood-test diagnosis
86.8% of patients in this cohort presented more than one pathology. The combined structural effect of these pathologies was a focal impact on hippocampal grey matter atrophy, primarily driven by HS and Alzheimer's pathology (family-wise error corrected, p < 0.05), which also exhibited the strongest individual effects (uncorrected, p < 0.001). WMHs, predominant in middle and anterior cerebral portions, were most strongly associated with vascular (T = 2.47, p = 0.017) and tau pathologies (T = 2.09, p = 0.041). The mixed associations of these dementia neuroimaging hallmarks are relevant for the fine-tuning of diagnostic protocols and underscore the need for comprehensive pathology evaluations in the study of dementia phenotypes.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ortega‐Cruz, D., Rábano, A., & Strange, B. A. (2025). Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-024-01633-2
Vancouver
Ortega‐Cruz D, Rábano A, Strange BA. Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-024-01633-2. PMID: 39789603.
BibTeX
@article{ortegacruz2025-39789603,
author = {Ortega‐Cruz, Diana and Rábano, Alberto and Strange, Bryan Andrew},
title = {{Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia}},
journal = {Alzheimer s Research \& Therapy},
year = {2025},
doi = {10.1186/s13195-024-01633-2},
pmid = {39789603},
url = {https://doi.org/10.1186/s13195-024-01633-2}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- 86.8% of patients in this cohort presented more than one pathology.
- The combined structural effect of these pathologies was a focal impact on hippocampal grey matter atrophy, primarily driven by HS and Alzheimer's pathology (family-wise error corrected, p < 0.05), which also exhibited the strongest individual effects (uncorrected, p < 0.001).
- WMHs, predominant in middle and anterior cerebral portions, were most strongly associated with vascular (T = 2.47, p = 0.017) and tau pathologies (T = 2.09, p = 0.041).
- The mixed associations of these dementia neuroimaging hallmarks are relevant for the fine-tuning of diagnostic protocols and underscore the need for comprehensive pathology evaluations in the study of dementia phenotypes.
Why it matters
Most people in this dementia cohort had more than one brain pathology, and hippocampal grey matter shrinkage was mainly linked to hippocampal sclerosis and Alzheimer's pathology, while white matter hyperintensities were most strongly linked to vascular and tau pathology. The authors say these mixed findings highlight the need for thorough pathology evaluation when studying dementia, which could help refine diagnostic protocols.
Study details
- Effect size86.8%
- Evidence strengthModerate
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Bryan Andrew Strange: h-index 39 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad Politécnica de Madrid: institution h-index 432 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39789603) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-024-01633-2
- PubMed: 39789603
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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