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Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function
Schirge PM, Perneczky R, Taoka T, Ruiz-Rizzo AL, Ersoezlue E, Forbrig R, Guersel S, Kurz C et al.. Alzheimer's research & therapy, 2025-03-18
Topic: Amyloid, tau and blood-test diagnosis
Background Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance. The diffusion tensor image analysis along the perivascular space (DTI-ALPS; ALPS-Index) has emerged as a novel, non-invasive method to evaluate the glymphatic system in vivo, showing glymphatic insufficiency in AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Schirge, P. M., Perneczky, R., Taoka, T., Ruiz-Rizzo, A. L., Ersoezlue, E., Forbrig, R., et al. (2025). Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-025-01707-9
Vancouver
Schirge PM, Perneczky R, Taoka T, Ruiz-Rizzo AL, Ersoezlue E, Forbrig R, et al. Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function. Alzheimer's research & therapy. 2025. doi:10.1186/s13195-025-01707-9. PMID: 40098158.
BibTeX
@article{schirge2025-40098158,
author = {Schirge, P. M. and Perneczky, R. and Taoka, T. and Ruiz-Rizzo, A. L. and Ersoezlue, E. and Forbrig, R. and Guersel, S. and Kurz, C. and others},
title = {{Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function}},
journal = {Alzheimer's research \& therapy},
year = {2025},
doi = {10.1186/s13195-025-01707-9},
pmid = {40098158},
url = {https://doi.org/10.1186/s13195-025-01707-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance.
- The diffusion tensor image analysis along the perivascular space (DTI-ALPS; ALPS-Index) has emerged as a novel, non-invasive method to evaluate the glymphatic system in vivo, showing glymphatic insufficiency in AD.
- This study aimed to investigate alterations in the function of the glymphatic system in individuals with AD versus healthy controls (HC), and to explore its association with Aβ, cerebrovascular disease (CVD), white matter hyperintensities (WMH), and cognitive function.
- Methods DTI MRI data from three independent study cohorts (ActiGliA: AD n = 16, Controls n = 18; DELCODE: AD n = 54, Controls n = 67; ADNI: AD n = 43, Controls n = 49) were used to evaluate the perivascular space (PVS) integrity; a potential biomarker for glymphatic activity.
Why it matters
This study investigated whether the brain's glymphatic system, which helps clear amyloid-beta, works differently in people with Alzheimer's disease compared to healthy controls. It used a non-invasive imaging method to assess this system, which could improve understanding of how vascular factors contribute to Alzheimer's.
Study details
- Participants16
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 16 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 48 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 16.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 17.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 48 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Boris‐Stephan Rauchmann: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Imperial College London: institution h-index 1,744 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 22 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40098158) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-025-01707-9
- PubMed: 40098158
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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