Newest studies

Sleep Quality of Persons with Dementia and Family Caregivers in Korean Americans: Wearable Technology to Study the Dyadic Association

39/100 ✓ Peer-reviewed Caregiving Western Journal of Nursing Research

Key finding: A total of 11 dyads participated in the study. +4 more findings

• Caregiving
• Digital Tools
• Lifestyle

Full summary, score breakdown and related studies → Original source

A Skill-Based multimodal intervention for dementia caregivers: impact on burden and anxiety

57/100 ✓ Peer-reviewed Caregiving Aging Clinical and Experimental Research

Key finding: The sample consisted predominantly of women (79% in the intervention group, 69% in the control group), with daughters forming the largest caregiver subgroup (66.6% and 52.4%, respectively). +4 more findings

• Caregiving
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Absence of care among community-dwelling older adults with dementia and functional limitations

57/100 ✓ Peer-reviewed Caregiving Nature Aging

Key finding: Using harmonized longitudinal survey data (2012–2018) from the United States, England, 18 European countries, Israel and China, we found that at least one-fifth of persons with dementia and functional limitations received no personal assistance for basic activities of daily living or instrumental activities of daily living, regardless of regional development level. +1 more finding

Full summary, score breakdown and related studies → Original source

Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients

56/100 ✓ Peer-reviewed Getting a diagnosis BMC Psychiatry

Key finding: During follow-up ranging from 1.0 to 22.9 years, 75 patients (29.88%) converted to AD. +4 more findings

• Risk Factors

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The Montreal cognitive assessment (MoCA) 8.1 version, including the memory index score (MoCA-MIS): Italian norms

41/100 ✓ Peer-reviewed Getting a diagnosis Neurological Sciences

Key finding: The results showed that Age, Education, and, occasionally, Biological sex were significant predictors. +4 more findings

• Diagnosis

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Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities

49/100 ✓ Peer-reviewed Prevention and risk The Journal of Prevention of Alzheimer s Disease

Key finding: A European Task Force has recently developed and published the concept and protocols for the setup of the innovative health offer of Brain Health Services for the secondary prevention of dementia and cognitive impairment (dBHS). dBHS are outpatient health care facilities where adult persons can find an assessment of their risk of developing cognitive impairment and dementia, have their risk level and contributing factors communicated using appropriate language supported by adequate communication tools, can decide to participate to programs for personalized risk reduction if at higher risk, and benefit from cognitive enhancement interventions.

• Prevention
• Care Services

Full summary, score breakdown and related studies → Original source

Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions

49/100 ✓ Peer-reviewed Prevention and risk Alzheimer s Research & Therapy

Key finding: Adherence to these interventions is crucial for their success, yet there is significant heterogeneity in adherence reporting across studies, hindering the understanding of adherence barriers and facilitators. +1 more finding

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

65/100 ✓ Peer-reviewed Genetics PLoS Genetics

Key finding: Recent studies suggest that EOAD may be enriched for variants acting in the lipid pathway. +2 more findings

• Genetics

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DOENÇA DE ALZHEIMER E SEUS MECANISMOS EPIGENÉTICOS

28/100 ✓ Peer-reviewed Genetics Revista Foco

Key finding: Além disso, mudanças em genes ligados à plasticidade sináptica e ao metabolismo cerebral também podem contribuir para a doença. +4 more findings

• Genetics

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Equity of access in rural and metropolitan dementia diagnosis, management, and care experiences: an exploratory qualitative study

45/100 ✓ Peer-reviewed Caregiving International Journal for Equity in Health

Key finding: Participants were distributed across various regions of Australia: seven interviews from inner regional Australia, five interviews from outer regional Australia, and twenty-one interviews from metropolitan areas. +4 more findings

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Development and usability of the “Cognitive Evergreenland” app to engage individuals at high risk of dementia in lifestyle interventions

34/100 ✓ Peer-reviewed Prevention trials Scientific Reports

Key finding: Target users indicated overall satisfaction with usability.

• Digital Tools
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

Do microglia metabolize fructose in Alzheimer’s disease?

41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroinflammation

Key finding: Interestingly, this "metabolic reprogramming" may be linked to an increase in fructose metabolism. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction

43/100 ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

Key finding: Two logic models were developed to identify the determinants of risk for dementia and how these could be targeted by the program. +3 more findings

• Risk Factors

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The perceptions of European geriatricians on the co-occurrence and links between dementia, delirium and frailty

40/100 ✓ Peer-reviewed Disparities European Geriatric Medicine

Key finding: Within the 440 included surveys, respondents particularly over-estimated frailty prevalence in older hospitalised patients, with two-thirds choosing between 41 and 80% prevalence, when the literature suggests only 23-46%, but paradoxically underestimated the frequency of frailty in people with delirium (more than three quarters of responses across 21-80%; literature suggests 71-93%). +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Advance care planning and quality of life: A qualitative interview study in people with young-onset dementia and their family caregivers

43/100 ✓ Peer-reviewed Health systems and care delivery Palliative Medicine

Key finding: Four themes were found: sense of self, connection to others, acceptance versus resistance in the face of adversity, and orientation toward the future versus focus on the present. +4 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss

43/100 ✓ Peer-reviewed Drug development Journal of clinical medicine

Key finding: Beyond glycemic control, GLP1RAs have exhibited benefits in conditions associated with diabetes, including hypertension, dyslipidemia, non-alcoholic steatohepatitis, as well as in neurodegenerative diseases such as Alzheimer's disease.

• Treatments
• Risk Factors

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Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers

45/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

Key finding: In summary, specific biomarkers for AD-related pathologies allow accurate clinical diagnosis of AD based on pathobiological parameters. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Domestic violence in Lewy body dementia: A national study

37/100 ✓ Peer-reviewed Clinical safety Journal of Alzheimer s Disease

Key finding: A descriptive study using a transversal national online survey to evaluate the prevalence and characteristics of behavioral and psychological symptoms (BPSD) of dementia with Lewy bodies (DLB), and specifically, the perpetration of violent acts against primary caregivers. 196 responses, obtained in one month, were analyzed. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

73/100 ✓ Peer-reviewed Brain tissue and pathology Neuron

Key finding: Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Genome-wide association study of neuropathological features in Lewy body disease

53/100 ✓ Peer-reviewed Lewy body dementia Brain

Key finding: APOE ε4) was associated with a greater severity of each of Braak NFT stage [odds ratio (OR) = 3.07, P = 2.34 × 10-32], Thal amyloid phase (OR = 3.57, P = 3.28 × 10-29) and LBD subtype (OR = 1.78, P = 9.85 × 10-9), with similar findings observed in the independent replication series (Braak NFT stage, OR = 2.30, P = 2.70 × 10-11; Thal amyloid phase, OR = 3.17, P = 6.39 × 10-18; LBD subtype, OR = 2.68, P = 3.85 × 10-10). +4 more findings

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations between neuropsychiatric symptoms and pathology in clinicopathologically defined Alzheimer's disease, Alzheimer's disease with Lewy bodies, and dementia with Lewy bodies

45/100 ✓ Peer-reviewed Lewy body dementia Journal of Alzheimer s Disease

Key finding: Early NPS burden as well as NPS severity progression rate, independently of cognitive status, might be useful clinical metrics and may help predict underlying pathological diagnoses. +2 more findings

• Other Dementias

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The global, regional, and national burdens of dementia in 204 countries and territories from 1990 to 2021: A trend analysis based on the Global Burden of Disease Study 2021

45/100 ✓ Peer-reviewed How common it is Medicine

Key finding: The analysis revealed that, from 1990 to 2021, the global AAPC in dementia incidence, prevalence, and disability-adjusted life years amounted to 0.06 (95% confidence interval [CI]: 0.05-0.09), 0.09 (95% CI: 0.08-0.10), and 0.03 (95% CI: 0.01-0.05), respectively. +2 more findings

Full summary, score breakdown and related studies → Original source

Is caregiver burden associated with sex and gender-related characteristics? A large-scale survey study among family caregivers of people with dementia

50/100 ✓ Peer-reviewed Caregiving BMC Geriatrics

Key finding: Female caregivers perceived a greater care burden than male caregivers. +4 more findings

• Caregiving

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Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention

47/100 ✓ Peer-reviewed Prevention and risk Journal of Nanobiotechnology

Key finding: To address the potential health risks associated with NBNs, we propose future strategies for risk prevention, including the development of safer nanomaterial designs, implementation of stringent regulatory guidelines, and advancement of novel toxicity testing approaches.

• Prevention
• Side Effects
• Brain Biology

Full summary, score breakdown and related studies → Original source

Dietary patterns and blood-based biomarkers of Alzheimer's disease in cognitively intact older adults: Findings from a population-based study

52/100 ✓ Peer-reviewed Tau biomarkers The journal of prevention of Alzheimer's disease

Key finding: Diet can impact cognitive aging, but comprehensive data from human studies is lacking and the underlying biological mechanisms are still not fully understood. +3 more findings

• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source