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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Prevention of dementia represents a public health priority. Hypertension is a risk factor for mild cognitive impairment (MCI), a precursor to progressive dementia. A great effort is underway to develop accurate and sensitive tools to detect the MCI condition in hypertensive patients. To investigate the potential association of subclinical left ventricular dysfunction expressed by the global longitudinal strain (GLS) with the MCI, defined by the Italian version of the quick mild cognitive impairment (Qmci-I). This multi-centric study included 180 consecutive hypertensive patients without medical diseases and/or drugs with known significant effects on cognition but with a not negligible comorbidity burden to avoid a possible "hyper-normality bias". The study cohort was classified into two main groups concerning the median value of the GLS. A weighted logistic regression model was employed after an inverse probability of treatment weighting (IPTW) analysis to characterize a potential association between GLS and MCI. Almost 41,1% of the whole study population was female. The mean age was 65,6 ± 7,2. 39 patients (21,7%) showed MCI. After IPTW, the GLS was significantly associated with the study endpoint (OR, 1,22; 95% CI: 1,07-1,39, P = 0.003). Our results highlight that the GLS is a potential predictor of MCI and, therefore, a valuable tool for establishing preventive strategies to arrest the progression toward a cognitive decline in hypertensive patients.

Key findings

This multi-centric study included 180 consecutive hypertensive patients without medical diseases and/or drugs with known significant effects on cognition but with a not negligible comorbidity burden to avoid a possible "hyper-normality bias".
After IPTW, the GLS was significantly associated with the study endpoint (OR, 1,22; 95% CI: 1,07-1,39, P = 0.003).
Our results highlight that the GLS is a potential predictor of MCI and, therefore, a valuable tool for establishing preventive strategies to arrest the progression toward a cognitive decline in hypertensive patients.

Why it matters

In 180 hypertensive patients, subclinical left ventricular dysfunction measured by global longitudinal strain was significantly associated with mild cognitive impairment. This is an observational association and does not test any treatment, cure or prevention.

Study details

Study designlongitudinal study
Participants180
Evidence strengthModerate

How this study scored 55/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Hypertension Research)
Journal's citation record	1 / 4	Hypertension Research: journal h-index 126 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	180 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 8 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 5.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Michele Ciccarelli: h-index 50 (OpenAlex, whole career)
Institution's track record	1 / 3	Albert Einstein College of Medicine: institution h-index 973 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40097616)
Free to read	2 / 2	Free to read
Total	55 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Ferruzzi, G. J., Campanile, A., Visco, V., Loria, F., Mone, P., Masarone, D., et al. (2025). Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients. Hypertension Research. https://doi.org/10.1038/s41440-025-02182-3

Vancouver

Ferruzzi GJ, Campanile A, Visco V, Loria F, Mone P, Masarone D, et al. Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients. Hypertension Research. 2025. doi:10.1038/s41440-025-02182-3. PMID: 40097616.

BibTeX

@article{ferruzzi2025-40097616,
  author  = {Ferruzzi, Germano Junior and Campanile, Alfonso and Visco, Valeria and Loria, Francesco and Mone, Pasquale and Masarone, Daniele and Dattilo, Giuseppe and Agnelli, Graziella and others},
  title   = {{Subclinical left ventricular dysfunction assessed by global longitudinal strain correlates with mild cognitive impairment in hypertensive patients}},
  journal = {Hypertension Research},
  year    = {2025},
  doi     = {10.1038/s41440-025-02182-3},
  pmid    = {40097616},
  url     = {https://doi.org/10.1038/s41440-025-02182-3}
}

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