Newest studies

Ginsenoside Rc mitigates hippocampal neuronal damage and cognitive impairment in vascular dementia rats via the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathways

37/100 ✓ Peer-reviewed Disease mechanisms Journal of Ginseng Research

Key finding: GRc exerted neuroprotective effects in VaD by targeting Stat3 and driving its dual-phosphorylation. +1 more finding

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Real-world health care costs and resource utilization associated with mild cognitive impairment in the United States: A retrospective cohort study of commercial and Medicare data

45/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Managed Care & Specialty Pharmacy

Key finding: < 0.0001) were significantly higher for the MCI cohort. +2 more findings

• Policy
• Early Stage

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Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation

38/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: These findings provide preliminary evidence that tPBM may effectively improve neuropsychological, physiological, and psychological outcomes in individuals with MCI. +3 more findings

• Early Stage

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A machine learning-based approach to predict depression in Chinese older adults with subjective cognitive decline: a longitudinal study

51/100 ✓ Peer-reviewed Mild cognitive impairment Scientific Reports

Key finding: Among all evaluated models, Boosted XGBoost demonstrated the highest predictive accuracy in the test set (AUC = 0.893), outperforming both Gradient Boosting (AUC = 0.887) and Random Forest (AUC = 0.861). +2 more findings

• Early Stage
• Digital Tools

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Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant Frontotemporal dementia

44/100 ✓ Peer-reviewed Lewy body dementia Journal of Neurology

Key finding: Forty bvFTD patients and 40 HC (56.25% female, mean age of 63.55 years) were involved. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Longitudinal Changes in Brain Diffusion Characteristics Associated With Cognition and Vascular Risk Factors

65/100 ✓ Peer-reviewed Risk factors Neurology

Key finding: Significant differences in annualized changes in these FA and MD values were found depending on the presence or absence of type 2 diabetes and smoking. +3 more findings

• Risk Factors

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Role of Mediterranean diet in the prevention of cognitive decline: Biological mechanisms behind longevity promotion

38/100 ✓ Peer-reviewed Prevention and risk Mediterranean Journal of Nutrition and Metabolism

Key finding: Observational and interventional studies consistently associate greater adherence to the Mediterranean diet with slower cognitive decline, reduced incidence of mild cognitive impairment, and lower risk of Alzheimer's disease.

• Lifestyle
• Prevention
• Brain Biology

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Long-term air pollution exposure and incident dementia: a systematic review and meta-analysis

69/100 ✓ Peer-reviewed Prevention and risk Lancet Planetary Health

Key finding: We found no significant association for exposure to nitrogen oxides (five studies, n=241 409, pooled adjusted HR per 10 μg/m 3 increase, 1·05 [0·97-1·13]; I 2 =44%), PM 10 (four studies, n=246 440, pooled adjusted HR per 15 μg/m 3 increase, 1·52 [0·80-2·87]; I 2 =82%), or annual ozone (four studies, n=419 972, pooled adjusted HR per 45 μg/m 3 increase, 0·82 [0·35-1·92]; I 2 =69%), with moderate to considerable heterogeneity between studies in these pooled analyses. +4 more findings

• Risk Factors

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Gut-brain relationship in dementia and Alzheimer's disease: Impact on stress and immunity

43/100 ✓ Peer-reviewed Disease mechanisms Ageing research reviews

Key finding: Importantly, we highlight that AD-related neurodegeneration can also feedback to impair gastrointestinal function and microbial composition, creating a self-reinforcing pathological loop. +4 more findings

• Genetics

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Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review

52/100 ✓ Peer-reviewed Inflammation and the immune system GeroScience

Key finding: Cross-sectional studies showed that, compared to cognitively normal individuals, the circulating level of primary BAs such as cholic acid (CA) is reduced, while glycochenodeoxycholic acid (GCDCA) and most secondary bile acids are increased in dementia. +2 more findings

• Risk Factors

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Practical Guide of the Korean Association for Geriatric Psychiatry to Anti-Amyloid Monoclonal Antibody Therapy for Alzheimer's Disease: Focused on Lecanemab

56/100 ✓ Peer-reviewed Health systems and care delivery Journal of Korean medical science

Key finding: It also emphasizes shared decision-making and outlines how to navigate situations where treatment is not appropriate, such as in patients with advanced dementia, high-risk magnetic resonance imaging findings, or poor treatment adherence, reinforcing that non-treatment can also represent a legitimate, evidence-based clinical decision. +4 more findings

• Treatments
• Clinical Trials
• Side Effects

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Having Their Cake and Eating it Too: An Exploratory Mixed-Methods Study on the Dietary Behaviours of Family Carers of Persons With Dementia

31/100 ✓ Peer-reviewed Prevention trials Dementia

Key finding: Family carers were food secure according to the FIES, and their overall diet quality was moderate, with a mean MEDAS score of 6.6 ± 2.1. +4 more findings

• Caregiving
• Lifestyle

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Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review

37/100 ✓ Peer-reviewed Disease mechanisms Journal of Geriatric Psychiatry and Neurology

Key finding: Growing evidence highlights the protective role of microglia in AD pathology through their immune functions, phagocytic clearance of Aβ proteins, and trophic support to promote tissue repair and maintain cerebral homeostasis, as alterations in their response to Aβ are linked to an increased risk of AD. +1 more finding

• Brain Biology
• Treatments

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Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

39/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Aging Neuroscience

Key finding: We then analyze reports on tau pathologies in aged NHPs compared to human aging and tauopathy, followed by an evaluation of current and emerging NHP models of tauopathy.

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Neuroinflammation and nutrition in Alzheimer’s disease

39/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in Neurology

Key finding: Very few therapeutics are available for neurodegenerative diseases due to the limited understanding of their pathogenesis, resulting in the lack of biomarkers and drug targets. +4 more findings

• Brain Biology
• Lifestyle

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Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis

38/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in Neuroscience

Key finding: Structural analyses revealed the selective interaction between KPNA subtypes, especially KPNA4, with the nuclear localisation signal (NLS) of TDP-43. +2 more findings

• Brain Biology
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations

48/100 ✓ Peer-reviewed TREM2 and immune genetics Redox biology

Key finding: Recent studies reveal that a dynamic interplay of programmed and non-programmed cell death mechanisms-amplified by oxidative damage-drives PD progression. +3 more findings

• Brain Biology
• Other Dementias

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Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer's Disease in Down Syndrome

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Sleep

Key finding: Higher wake percentage and shorter total sleep time were associated with greater Aβ and tau burden. +2 more findings

• Down Syndrome
• Diagnosis

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Preliminary investigation of obstructive sleep apnea and Alzheimer's disease in down syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Sleep advances : a journal of the Sleep Research Society

Key finding: Higher wake percentage and shorter total sleep time were associated with greater Aβ and tau burden. +2 more findings

• Down Syndrome
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer's disease patients

55/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Ninety-four proteins differentiated in the high-risk group compared to low-risk (p < 0.05), none surviving FDR correction. +4 more findings

• Side Effects

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From Amyloid to Synaptic Dysfunction: Biomarker-Driven Insights into Alzheimer's Disease

43/100 ✓ Peer-reviewed Biomarkers Current issues in molecular biology

Key finding: Traditionally, diagnosis has relied on clinical symptoms and neuroimaging; however, the introduction of biomarkers has revolutionized disease assessment. +4 more findings

• Biomarkers
• Brain Biology

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Validity and Reliability of a Chinese-Tailored Scale for the Evaluation of End-of-Life Care in Dementia Patients

26/100 ✓ Peer-reviewed End-of-life care British Journal of Hospital Medicine

Key finding: In this study, a preliminary reliability assessment on the Chinese version of the EOLD scale was conducted, revealing that the three subscales exhibit strong internal consistency in reliability and structural validity. +1 more finding

• End-of-Life Care

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How to Implement Advance Care Planning for People With Dementia: A Scoping Review

36/100 ✓ Peer-reviewed End-of-life care Journal of Advanced Nursing

Key finding: The review included 45 studies and identified key components and processes for successfully implementing advance care planning in dementia care. +4 more findings

• End-of-Life Care

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BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease

39/100 ✓ Peer-reviewed Risk factors Brain Research Bulletin

Key finding: Interestingly, recent evidence suggests that these fluid-based biomarkers reflective of BACE1 elevation may be associated with yet asymptomatic pathological changes in preclinical AD populations who are at high-risk for developing AD. +2 more findings

• Risk Factors
• Biomarkers
• Early Stage

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Multidimensional sleep profiles via machine learning and risk of dementia and cardiovascular disease

54/100 ✓ Peer-reviewed Digital health tools Communications Medicine

Key finding: We identify three distinct profiles: active healthy sleepers (AHS; 64.0%), fragmented poor sleepers (FPS; 14.1%), and long and frequent nappers (LFN; 21.9%). +2 more findings

• Risk Factors
• Digital Tools
• Lifestyle

Full summary, score breakdown and related studies → Original source