Newest studies

Cognitive Reserve Relationship with Physical Performance in Dementia-Free Older Adults: The MIND-China Study

61/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease reports

Key finding: Greater educational attainment and mental activity were associated with higher composite SPPB scores and those of its three subtests (p < 0.05). +4 more findings

Full summary, score breakdown and related studies → Original source

Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders

43/100 ✓ Peer-reviewed Treatments Aging and disease

Key finding: The prevalence of neurocognitive disorders (NCD) increases every year as the population continues to age, leading to significant global health concerns. +1 more finding

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Pharmacologic Treatments for Dementia and the Risk of Developing Age-Related Macular Degeneration

75/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: There were 132 846 individuals (mean [SD] age, 80.4 [7.6] years; 61.8% women; mean [SD] body mass index [BMI], 25.5 [4.6]) with a diagnosis of dementia included in cohort 1, 159 419 individuals (mean [SD] age, 81.2 [7.6] years; 59.7% women; mean [SD] body mass index [BMI], 25.6 [4.7]) with a diagnosis of dementia included in cohort 2, and 92 328 individuals with a diagnosis of dementia included in cohort 3 (mean [SD] age, 80.9 [7.7] years; 58.5% women; mean [SD] body mass index [BMI], 25.5 [4.7]). +4 more findings

• Treatments

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[Anti-Amyloid Antibody Therapy for Alzheimer's Disease]

43/100 ✓ Peer-reviewed Treatments Brain and nerve = Shinkei kenkyu no shinpo

Key finding: Previously, the mature fibrils and plaques were implicated as contributors to neurotoxicity and neurodegeneration. +4 more findings

• Treatments
• Clinical Trials
• Brain Biology

Full summary, score breakdown and related studies → Original source

Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240

46/100 ✓ Peer-reviewed Brain scans and imaging Nature communications

Key finding: Positron Emission Tomography (PET) ligands have advanced Alzheimer's disease (AD) diagnosis and treatment. +2 more findings

• Brain Scans

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Role of Apolipoprotein E in Alzheimer's Disease Pathogenesis, Prognosis and Treatment

43/100 ✓ Peer-reviewed Genetics Discovery medicine

Key finding: Previous trials of anti-amyloid and anti-tau immunotherapy indicate that additional research needs to be conducted on other mechanisms to find curative or disease-modifying therapy.

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Clinical Meaningfulness in Alzheimer's Disease Clinical Trials. A Report from the EU-US CTAD Task Force

46/100 ✓ Peer-reviewed Health systems and care delivery The journal of prevention of Alzheimer's disease

Key finding: Recent positive results of three phase III anti-amyloid monoclonal antibody trials are transforming the landscape of disease-modifying therapeutics for Alzheimer's disease, following several decades of failures. +1 more finding

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community‐dwelling cohort

34/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: ADI was positively associated with blood pressure and cardiometabolic index (CMI), and negatively associated with global and Preclinical Alzheimer's Cognitive Composite (PACC5) scores, in cognitively unimpaired (CU) individuals. +3 more findings

• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment

68/100 ✓ Peer-reviewed Long-term cohort studies JAMA psychiatry

Key finding: Subjective cognitive decline (SCD) is recognized to be in the Alzheimer disease (AD) cognitive continuum. +3 more findings

• Early Stage

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Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment

63/100 ✓ Peer-reviewed Tau biomarkers JAMA network open

Key finding: It remains unclear which risk factors accelerate brain atrophy along with a progression from normal cognition to mild cognitive impairment (MCI). +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Early increases in plasma NfL may reflect early white matter microstructural changes prior to dementia in DS. +1 more finding

• Biomarkers
• Down Syndrome
• Brain Scans

Full summary, score breakdown and related studies → Original source

Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome

53/100 ✓ Peer-reviewed Down syndrome and Alzheimer's JAMA neurology

Key finding: These findings suggest significant binding of lecanemab to cerebral amyloid angiopathy in DS. +4 more findings

• Down Syndrome
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle

61/100 ✓ Peer-reviewed Digital health tools Diabetes care

Key finding: Diabetes and even prediabetes are associated with accelerated brain aging, especially among men and people with poor cardiometabolic health. +3 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Designing and implementing the IDEAL Study: A randomized clinical trial of APOE genotype disclosure for late-onset Alzheimer's disease in an urban Latino population

67/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: We sent invitations to 91,433 households; 5542 (6.1%) responded, 2120 completed the Baseline Survey (78.5% online; 21.5% via computer-assisted telephone interview), and 2087 were deemed eligible, yielding a response rate of 2.3%. +1 more finding

• Clinical Trials
• Genetics

Full summary, score breakdown and related studies → Original source

Challenges in a Biological Definition of Alzheimer Disease

60/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: It has been suggested that the diagnostic landscape of Alzheimer disease (AD) is undergoing a profound transformation, marked by a shift toward a biomarker-based approach, as proposed by the Revised Criteria for Diagnosis and Staging of Alzheimer's Disease. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care

72/100 ✓ Peer-reviewed Biomarkers JAMA

Key finding: The mean age was 74.2 years (SD, 8.3 years), 48% were women, 23% had subjective cognitive decline, 44% had mild cognitive impairment, and 33% had dementia. +1 more finding

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Annual Wellness Visits and Early Dementia Diagnosis Among Medicare Beneficiaries

66/100 ✓ Peer-reviewed Getting a diagnosis JAMA Network Open

Key finding: These findings indicate that AWV recipients had a timelier first MCI diagnosis than those who did not receive an AWV, but first ADRD diagnosis differed little. +4 more findings

• Diagnosis
• Policy

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Clinical effectiveness of DREAMS START (Dementia Related Manual for Sleep; Strategies for Relatives) versus usual care for people with dementia and their carers: a single-masked, phase 3, parallel-arm, superiority randomised controlled trial

72/100 ✓ Peer-reviewed Caregiving The Lancet Healthy Longevity

Key finding: Between Feb 24, 2021, and March 5, 2023, 377 dyads were randomly assigned (1:1), 189 to usual treatment and 188 to intervention. +1 more finding

• Clinical Trials
• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Exercise, Neuroprotective Exerkines, and Parkinson's Disease: A Narrative Review

43/100 ✓ Peer-reviewed Prevention trials Biomolecules

Key finding: In conclusion, exercise and exerkines together create a powerful neuroprotective system that should contribute to slowing the chronic progression of PD.

• Treatments
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies

43/100 ✓ Peer-reviewed TREM2 and immune genetics Theranostics

Key finding: The 64Cu-labeled antibodies were obtained in high radiochemical purity (RCP), radiochemical yield (RCY), and specific activity. +4 more findings

• Brain Scans
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Validity of the Tablet-Based Digital Cognitive Test (SCST) in Identifying Different Degrees of Cognitive Impairment

52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Korean medical science

Key finding: The SCST total score, cognitive domain scores (attention, language, visuospatial function, memory, executive function), and most of the subtest scores decreased significantly in the order of SCD, MCI and dementia. +4 more findings

• Diagnosis

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Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

51/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron

Key finding: Here, we combine APOE4 and TREM2 R47H (R47H) in female P301S tauopathy mice to identify the pathways activated when AD risk is the strongest, thereby highlighting detrimental disease mechanisms. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus

43/100 ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity

Key finding: Electroencephalographic analysis, immunocytochemistry, and RNA sequencing revealed that TREM2 deficiency significantly promoted seizure-induced pathology. +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

The Mediterranean Diet: A powerful defense against Alzheimer disease-A comprehensive review

50/100 ✓ Peer-reviewed Prevention and risk Clinical nutrition ESPEN

Key finding: Specific Mediterranean diet components like vegetables, fruits, legumes, cereals, fish, and monounsaturated fats might contribute to cognitive benefits. +4 more findings

• Lifestyle

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GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis

46/100 ✓ Peer-reviewed Disease mechanisms Nature communications

Key finding: These findings suggest GV-971 as a promising therapeutic for SAP by targeting the microbiota metabolic immune axis.

• Brain Biology
• Treatments
• Prevention

Full summary, score breakdown and related studies → Original source