Newest studies

Potentially Inappropriate Medication Use Among Patients With Dementia in Traditional Medicare and Medicare Advantage

33/100 ✓ Peer-reviewed Health systems and care delivery Medical Care

Key finding: MA-PD enrollees had significantly lower utilization of PIMs than standalone PDP enrollees: a 0.7 percentage-point [95% CI: 0.5, 0.8] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia; a 3.1 percentage-point [2.6, 3.5] lower prevalence of potentially harmful drug-disease interactions in older adults with dementia and a history of falls; and a 0.5 percentage-point [0.4, 0.6] lower prevalence of high-risk medications in older adults. +2 more findings

• Treatments
• Policy

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The role of the components of PM2.5 in the incidence of Alzheimer’s disease and related disorders

51/100 ✓ Peer-reviewed How common it is Environment International

Key finding: We found positive associations between the 15 PM 2.5 components and the incidence of dementia and AD. +2 more findings

• Risk Factors

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Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq

43/100 ✓ Peer-reviewed Genetics Neuron

Key finding: We found that Aβ42 primarily affects the nervous system, including sensory neurons, while Tau induces accelerated aging in peripheral tissues. +1 more finding

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“You like to be in control of your own destiny to a degree, don't you?”: conscientious autonomy and planning for future care with dementia

42/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: Participants sought to feel secure by following recommended practices, manage uncertainty, avoid crises, share burdens within families, and avoid poor end-of-life experiences. +4 more findings

• End-of-Life Care

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Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods

46/100 ✓ Peer-reviewed Clinical safety Journal of Geriatric Psychiatry and Neurology

Key finding: PurposeDelirium is a common yet preventable complication of hospitalization, surgery and illness that is associated with poor outcomes.

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Delirium as a Precursor to Dementia in Elderly Type 2 Diabetes Mellitus Patients

33/100 ✓ Peer-reviewed Clinical safety The Journal of Clinical Psychiatry

Key finding: Our findings confirm a strong association between delirium and an increased risk of dementia in elderly (≥65 years) T2DM patients, suggesting a potential causal link. +1 more finding

• Risk Factors

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Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium

64/100 ✓ Peer-reviewed How common it is SLEEP

Key finding: The pooled sample comprised 4657 participants (30% women) aged ≥ 60 years (mean age was 74 years at sleep assessment). +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Trends in Home Health Care Among Traditional Medicare Beneficiaries With or Without Dementia

51/100 ✓ Peer-reviewed Caregiving JAMA Network Open

Key finding: Among the 13 604 086 traditional Medicare beneficiaries included in the study (mean [SD] age, 79.4 [7.7] years; 60.4% women), 27.7% had a diagnosis of dementia. +4 more findings

• Policy
• Care Services

Full summary, score breakdown and related studies → Original source

Harnessing artificial intelligence for transforming dementia care: Innovations in early detection and treatment

42/100 ✓ Peer-reviewed Caregiving Brain Organoid and Systems Neuroscience Journal

Key finding: Dementia, particularly Alzheimer's Disease, continues to be a significant global health concern, driven by increasing prevalence as the population ages.

• Diagnosis
• Digital Tools
• Treatments

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Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia

54/100 ✓ Peer-reviewed Getting a diagnosis Translational Psychiatry

Key finding: Multiple testing significance was corrected using false discovery rate, with results presented as Q-values. +2 more findings

• Diagnosis
• Biomarkers
• Lifestyle

Full summary, score breakdown and related studies → Original source

Socially inclusive infrastructure for disaster risk reduction in urban planning: insights from the SADC region

38/100 ✓ Peer-reviewed Prevention and risk Frontiers in Built Environment

Key finding: In response to these challenges, the study recommends a paradigm shift in urban planning towards the adoption of future-oriented and participatory approaches.

• Prevention

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Hearing impairment and dementia: cause, catalyst or consequence?

48/100 ✓ Peer-reviewed Prevention and risk Journal of Neurology

Key finding: The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. +1 more finding

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Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging

46/100 ✓ Peer-reviewed Prevention trials Neurobiology of aging

Key finding: Linear mixed-effects models showed an attenuated effect of β-amyloid on non-memory cognition decline in positive profiles (positive-active: β=3.7, p = 0.008, positive-affective: β=3.7, p = 0.007) compared to the negative profile. +2 more findings

• Prevention
• Risk Factors

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Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population

55/100 ✓ Peer-reviewed Biomarkers NPJ Parkinson's disease

Key finding: As a result, the APOE ε4 allele significantly increased DLB risk (p = 1.84E-11), while rare missense variants of USP13 gene were first found to be suggestively associated with DLB risk (p = 1.31E-5). +3 more findings

• Biomarkers
• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Outcomes of Physical and Occupational Therapy Evaluation in the Emergency Department for Older Adults With Falls: A Retrospective Multicenter Cohort

52/100 ✓ Peer-reviewed Clinical safety Journal of the American College of Emergency Physicians Open

Key finding: In total, 945 were included patients, and 28.1% (n = 266) had dementia. +4 more findings

• Treatments
• Care Services

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Dementia care management in primary care practices: a descriptive study among nurse practitioners

45/100 ✓ Peer-reviewed Clinical safety BMC Family Practice

Key finding: NPs reported that the quality of dementia care in their practices is poorer than the overall care provided. +4 more findings

• Care Services

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Association of Cardiovascular‐Kidney‐Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights

48/100 ✓ Peer-reviewed Long-term cohort studies Journal of the American Heart Association

Key finding: Elevated CKM risk level is significantly associated with increased risks of cognitive decline and dementia incidence. +2 more findings

• Risk Factors

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Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients

35/100 ✓ Peer-reviewed Mild cognitive impairment Biology

Key finding: Alzheimer’s disease (AD) remains a significant global health challenge with limited FDA-approved treatments, necessitating the search for novel preventive strategies. +2 more findings

• Early Stage
• Brain Biology
• Treatments

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Prognostic Value of a Multivariate Gut Microbiome Model for Progression from Normal Cognition to Mild Cognitive Impairment Within 4 Years

48/100 ✓ Peer-reviewed Mild cognitive impairment International Journal of Molecular Sciences

Key finding: Logistic regression models were built with baseline features that best discriminated between the two groups using an ANOVA-type statistical analysis. +4 more findings

• Early Stage

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Revealing heterogeneity in mild cognitive impairment based on individualized structural covariance network

38/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s Research & Therapy

Key finding: In the ADNI dataset, MCI patients exhibited significant alterations in structural covariance edges, mainly involving the hippocampus, parahippocampal gyrus, and amygdala. +4 more findings

• Early Stage

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Could self-reporting sleep duration become an important tool in the prediction of dementia?

50/100 ✓ Peer-reviewed Risk factors Expert Review of Neurotherapeutics

Key finding: In preclinical studies, partial or complete sleep deprivation produced inflammation, oxidative stress, as well as increased tau hyperphosphorylation and amyloid-β burden. +1 more finding

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Ethical issues associated with assistive technologies for persons living with dementia and their caregivers – An overview of reviews

39/100 ✓ Peer-reviewed Caregiving Dementia

Key finding: Assistive technologies hold significant potential to enhance the quality of life for persons with dementia and their caregivers by addressing key concerns related to safety, independence, and social inclusion. +3 more findings

• Digital Tools
• Caregiving

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Time-Dependent Risk of Dementia Following Epilepsy Diagnosis: A Nationwide Cohort Study in South Korea

53/100 ✓ Peer-reviewed Getting a diagnosis Archives of Clinical Neuropsychology

Key finding: Dementia risk was significantly higher in patients with epilepsy compared with that of controls (IRR: 3.65; 95% CI: 3.14-4.24), especially within the first 2 years post-diagnosis (aHR: 5.42; 95% CI: 4.30-6.83), peaking between 8 and 10 years (aHR: 8.25; 95% CI: 3.15-21.5). +4 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Disparities in Early Lecanemab Uptake Among US Medicare Beneficiaries

50/100 ✓ Peer-reviewed Treatments JAMA Network Open

Key finding: This cross-sectional study examines lecanemeb update among Medicare fee-for-service beneficiaries with Alzheimer disease or mild cognitive impairment and evaluates whether there are disparities among potentially eligible patients.

• Treatments
• Health Equity
• Policy

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Olfaction and Plasma Biomarkers of Alzheimer Disease and Neurodegeneration in the Atherosclerosis Risk in Communities Study

60/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Our findings suggest that poor olfaction is associated with multiple AD-related and other neurodegenerative processes. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source