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Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI
Mattia Ricchi, Guido Campani, Anastasiia Nagmutdinova, Villiam Bortolotti, Danilo Greco, Carlo Golini, James T. Grist, Leonardo Brizi et al.. European Radiology Experimental, 2025-03-19
Topic: Amyloid, tau and blood-test diagnosis
The subdivisions exhibit different pathways, terminations, and structural characteristics. We found differences in almost all the diffusivity metrics among the subdivisions (p < 0.001 for all the metrics) and between AD versus CN and MCI versus CN subjects for mean diffusivity (p = 0.007-0.038), radial diffusivity (p = 0.008-0.049) and neurite dispersion index (p = 0.005-0.049). Results from tractography analysis of the subdivisions of the cingulum bundle showed an association in the role of groups of fibers with their functions and the variance of their properties in relation to dementia progression. RELEVANCE STATEMENT: The cingulum bundle is a complex tract with several pathways and terminations related to many cognitive functions. A probabilistic automatic approach is proposed to reconstruct its subdivisions, showing different microstructural properties and variations. A larger sample of patients is needed to confirm results and elucidate the role of diffusion parameters in characterizing alterations in brain function and progression to dementia. KEY POINTS: The microstructure of the cingulum bundle is related to brain cognitive functions. A probabilistic automatic approach is proposed to reconstruct the subdivisions of the cingulum bundle by diffusion-weighted images. The subdivisions showed different microstructural properties and variations in relation to the progression of dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Ricchi, M., Campani, G., Nagmutdinova, A., Bortolotti, V., Greco, D., Golini, C., et al. (2025). Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI. European Radiology Experimental. https://doi.org/10.1186/s41747-025-00570-5
Vancouver
Ricchi M, Campani G, Nagmutdinova A, Bortolotti V, Greco D, Golini C, et al. Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI. European Radiology Experimental. 2025. doi:10.1186/s41747-025-00570-5. PMID: 40106095.
BibTeX
@article{ricchi2025-40106095,
author = {Ricchi, Mattia and Campani, Guido and Nagmutdinova, Anastasiia and Bortolotti, Villiam and Greco, Danilo and Golini, Carlo and Grist, James T. and Brizi, Leonardo and others},
title = {{Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI}},
journal = {European Radiology Experimental},
year = {2025},
doi = {10.1186/s41747-025-00570-5},
pmid = {40106095},
url = {https://doi.org/10.1186/s41747-025-00570-5}
}
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Key findings
- The subdivisions exhibit different pathways, terminations, and structural characteristics.
- We found differences in almost all the diffusivity metrics among the subdivisions (p < 0.001 for all the metrics) and between AD versus CN and MCI versus CN subjects for mean diffusivity (p = 0.007-0.038), radial diffusivity (p = 0.008-0.049) and neurite dispersion index (p = 0.005-0.049).
- Results from tractography analysis of the subdivisions of the cingulum bundle showed an association in the role of groups of fibers with their functions and the variance of their properties in relation to dementia progression.
- RELEVANCE STATEMENT: The cingulum bundle is a complex tract with several pathways and terminations related to many cognitive functions.
- A probabilistic automatic approach is proposed to reconstruct its subdivisions, showing different microstructural properties and variations.
Why it matters
This study found microstructural differences in subdivisions of the cingulum bundle between Alzheimer disease, mild cognitive impairment, and cognitively normal subjects. The authors state that a larger sample is needed to confirm results and clarify the role of diffusion parameters in progression to dementia.
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Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European Radiology Experimental) |
| Journal's citation record | 0 / 4 | European Radiology Experimental: journal h-index 50 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Claudia M. Testa: h-index 52 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40106095) |
| Free to read | 2 / 2 | Free to read |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s41747-025-00570-5
- PubMed: 40106095
- Original source →
- Free full text: European Radiology Experimental →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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