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64/100

✓ Peer-reviewed alzhub usefulness score 64 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

Of 733 participants (mean age 82.5 ± 2.9 years), 164 (22.4%) developed MCI and 93 (12.7%) developed dementia by the follow-up visit. We identified 3 sleep-wake change profiles: stable sleep (SS; n = 321 [43.8%]) was characterized by stability or small improvements; declining nighttime sleep (n = 256 [34.9%]) showed decreases in nighttime sleep quality and duration, moderate napping increases, and worsening circadian RARs; and increasing sleepiness (IS; n = 156 [21.3%]) exhibited large increases in daytime and nighttime sleep duration and quality, and worsening circadian RARs. After adjustment for age, education, race, body mass index, diabetes, hypertension, myocardial infarction, antidepressant use, and baseline cognition, women with IS had approximately double the risk of dementia (odds ratio 2.21, 95% CI 1.14-4.26) compared with those with SS. SE, WASO, nap duration, and nap frequency were individually associated with dementia. Neither sleep-wake change profiles nor individual parameters were associated with MCI. Among community-dwelling women in their 80s, those with increasing 24-hour sleepiness over 5 years had doubled dementia risk during that time. Change in multidimensional 24-hour sleep-wake activity may serve as an early marker or risk factor for dementia in oldest old women.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Milton, S., Cavaillès, C., Ancoli‐Israel, S., Stone, K. L., Yaffe, K. S., & Leng, Y. (2025). Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women. Neurology. https://doi.org/10.1212/wnl.0000000000213403

Vancouver

Milton S, Cavaillès C, Ancoli‐Israel S, Stone KL, Yaffe KS, Leng Y. Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women. Neurology. 2025. doi:10.1212/wnl.0000000000213403. PMID: 40106755.

BibTeX

@article{milton2025-40106755,
  author  = {Milton, Sasha and Cavaillès, Clémence and Ancoli‐Israel, Sonia and Stone, Katie L. and Yaffe, Kristine S. and Leng, Yue},
  title   = {{Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213403},
  pmid    = {40106755},
  url     = {https://doi.org/10.1212/wnl.0000000000213403}
}

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Key findings

Of 733 participants (mean age 82.5 ± 2.9 years), 164 (22.4%) developed MCI and 93 (12.7%) developed dementia by the follow-up visit.
We identified 3 sleep-wake change profiles: stable sleep (SS; n = 321 [43.8%]) was characterized by stability or small improvements; declining nighttime sleep (n = 256 [34.9%]) showed decreases in nighttime sleep quality and duration, moderate napping increases, and worsening circadian RARs; and increasing sleepiness (IS; n = 156 [21.3%]) exhibited large increases in daytime and nighttime sleep duration and quality, and worsening circadian RARs.
After adjustment for age, education, race, body mass index, diabetes, hypertension, myocardial infarction, antidepressant use, and baseline cognition, women with IS had approximately double the risk of dementia (odds ratio 2.21, 95% CI 1.14-4.26) compared with those with SS.
SE, WASO, nap duration, and nap frequency were individually associated with dementia.
Neither sleep-wake change profiles nor individual parameters were associated with MCI.

Why it matters

Among 733 community-dwelling women in their 80s followed for 5 years, those with increasing 24-hour sleepiness had about double the risk of dementia compared with those with stable sleep, while neither sleep-wake change profiles nor individual sleep parameters were associated with mild cognitive impairment. The authors suggest that changes in 24-hour sleep-wake activity may serve as an early marker or risk factor for dementia, not as a treatment or cure.

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Study details

Study designlongitudinal study
Participants321
Effect size22.4%; 12.7%; 43.8%
Evidence strengthModerate

How this study scored 64/100

Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	321 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 14 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.7 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 14.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Yue Leng: h-index 32 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40106755)
Free to read	2 / 2	Free to read
Total	64 / 100	—

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