Newest studies

Triadic Primary Care Encounters Managing Medications Among Individuals With Mild Cognitive Impairment and Dementia: Patient, Caregiver, and Clinician Perspectives

45/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: We enrolled 32 patients, 32 caregivers, and 25 clinicians. +4 more findings

• Caregiving
• Treatments

Full summary, score breakdown and related studies → Original source

Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials

79/100 ✓ Peer-reviewed Biomarkers Nature Aging

Key finding: In a head-to-head comparison study including nine cohorts and 1,474 individuals, we show that plasma p-tau217 and medial temporal lobe tau-PET signal display similar associations with cognitive decline on a global cognitive composite test (R 2 PET = 0.34 versus R 2 plasma = 0.33, P difference = 0.653) and with progression to mild cognitive impairment (hazard ratio (HR) PET = 1.61 (1.48-1.76) versus HR plasma = 1.57 (1.43-1.72), P difference = 0.322). +1 more finding

• Biomarkers
• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source

The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured Brain

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers bioRxiv : the preprint server for biology

Key finding: Comparative transcriptomic analysis at 6 and 48 hours post-injury revealed conserved mitochondrial impairments across excitatory neurons, interneurons, astrocytes, and microglia. +1 more finding

• Brain Biology

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Compared to non-carriers, APOE ε4 carriers had lower Aβ42/Aβ40 and greater longitudinal increases in p-tau181 and GFAP; in contrast, the AD-PRS (excluding the APOE region) was associated with greater declines in Aβ42/Aβ40 among APOE ε4 non-carriers. +3 more findings

• Biomarkers
• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Systematic review of differentially abundant proteins in people with Lewy body dementia

52/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropsychiatrica

Key finding: Our meta-analyses confirmed significantly lower CSF TAU levels in DLB and CSF SYUA levels in PDD, when compared to Alzheimer's disease. +3 more findings

• Other Dementias
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

45/100 ✓ Peer-reviewed Disease mechanisms Frontiers in Neuroscience

Key finding: These findings advocate for integrated therapeutic strategies targeting protein cross-seeding and proteostatic disruption while preserving physiological roles.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction

42/100 ✓ Peer-reviewed Inflammation and the immune system Current Issues in Molecular Biology

Key finding: As there is currently no curative therapy for cSVD, prevention or delay of cSVD remains of particular importance to preserve quality of life for as long as possible. +4 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report

44/100 ✓ Peer-reviewed Risk genes beyond APOE Arteriosclerosis Thrombosis and Vascular Biology

Key finding: We found that pharmacological activation of TREM2 suppressed laser-induced choroidal neovessel formation. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction

35/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Neurology

Key finding: This is the first reported case of AIWS in a patient with DLB. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Preliminary efficacy of an online intervention based on Acceptance and Commitment Therapy for family caregivers of people with dementia: a feasibility study

41/100 ✓ Peer-reviewed Caregiving Cognitive Behaviour Therapy

Key finding: Linear mixed-effect models based on a complete-case analysis showed significant changes in depressive symptoms (mean difference: −3.34, d = −0.78). +3 more findings

• Caregiving
• Treatments
• Digital Tools

Full summary, score breakdown and related studies → Original source

Identifying and Addressing Unmet Needs in Dementia: The Role of Care Access and Psychosocial Support

48/100 ✓ Peer-reviewed Caregiving International Journal of Geriatric Psychiatry

Key finding: People with dementia were on average 80.6 years old, mostly female (56%) and mildly to moderately cognitively impaired (85%). 98.6% of the participants had at least one need, of which just over a third (36.5%) were rated as met and just under two-thirds (63.5%) as unmet. +4 more findings

Full summary, score breakdown and related studies → Original source

Donanemab: Appropriate use recommendations

58/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: Appropriate Use Recommendations (AUR) were developed to guide the implementation of donanemab in real-world practice, prioritizing safety considerations and opportunity for effectiveness. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research

50/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: These immune cells undergo metabolic reprogramming in response to AD-related pathology, with key genes such as TREM2, APOE, and HIF-1α orchestrating these processes. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomized Controlled Trial

52/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: This study was approved by the institutional review board in April 2022 and funded in May 2022. +2 more findings

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Baseline associations of office and ambulatory blood pressure monitoring with cognitive function and dementia prevalence

46/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: BackgroundHigh blood pressure has been associated with dementia prevalence and incident. +2 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community

65/100 ✓ Peer-reviewed How common it is Nature Medicine

Key finding: In multi-adjusted Cox regression models, elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia, displaying a non-linear dose-response relationship. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Negative Consequences of Sleep Deprivation Experienced by Informal Caregivers of People With Dementia on Caregivers and Care Recipients: A Scoping Review

36/100 ✓ Peer-reviewed Caregiving International Journal of Nursing Practice

Key finding: Mental and physical effects caused by caregivers' sleep deprivation have been observed. +4 more findings

• Caregiving
• Lifestyle

Full summary, score breakdown and related studies → Original source

Nexus Between Exposure to Natural Outdoor Environments and Cognitive Competence among Older Adults in China

31/100 ✓ Peer-reviewed Risk factors Annals of the American Association of Geographers

Key finding: Using regression methods and stratified analysis, we demonstrate that there exists a positive relation between access to blue-green spaces and cognitive competence among older Chinese adults. +4 more findings

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Associations between plasma complement C1q and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study

45/100 ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

Key finding: However, the relationships between C1q and the major pathological challenges, including amyloid-β (Aβ) and tau deposition, remain undetermined in the preclinical AD phase. +1 more finding

• Biomarkers

Full summary, score breakdown and related studies → Original source

Current Technological Advances in Dysphagia Screening: Systematic Scoping Review

69/100 ✓ Peer-reviewed Clinical safety Journal of Medical Internet Research

Key finding: This review included 24 studies involving 2979 participants (1717 with dysphagia and 1262 controls). +4 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

The MIND diet, cognitive function, and well-being among healthy adults at midlife: a randomised feasibility trial

48/100 ✓ Peer-reviewed Prevention trials BMC Nutrition

Key finding: A repeated measures ANOVA showed that in comparison to the control group, both intervention groups significantly improved mood, quality of life, MIND diet score and all COM-B components at follow-up (p < 0.05). +4 more findings

• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

39/100 ✓ Peer-reviewed Inflammation and the immune system Neural Regeneration Research

Key finding: Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that exacerbates damage to dopaminergic neurons and contributes significantly to the pathology of neurodegenerative disorder. +1 more finding

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration

45/100 ✓ Peer-reviewed Lewy body dementia Journal of Neurology

Key finding: Radial diffusivity analyses detected impaired bilateral cerebello-frontal, cerebello-parietal, and cerebello-temporal connectivity in all study groups along the ALS-FTD spectrum. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences

40/100 ✓ Peer-reviewed Lewy body dementia Neural Regeneration Research

Key finding: Chronic cerebral hypoperfusion can lead to neuronal necrosis, trigger inflammatory responses, promote white matter damage, and ultimately result in cognitive impairment. +1 more finding

• Other Dementias
• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Type 2 diabetes and late-onset Alzheimer’s disease and related dementia: A longitudinal cohort study integrating polygenic risk score

46/100 ✓ Peer-reviewed How common it is Journal of Alzheimer s Disease

Key finding: T2DM is one of the strong risk factors of ADRD but genetic T2DM effect does not contribute to ADRD risk. +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source