Newest studies

Early detection of dementia through retinal imaging and trustworthy AI

59/100 ✓ Peer-reviewed Brain scans and imaging NPJ digital medicine

Key finding: Using 5751 OCTA images from 1671 participants in a multi-center study, our model demonstrated superior performance in EOAD (internal data: AUC = 0.9355, external data: AUC = 0.9007) and MCI detection (internal data: AUC = 0.8630, external data: AUC = 0.8037). +2 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Exploring Neighborhood-Level Environmental Justice to Tackle County-Level Disparities in Breast Cancer Outcomes

25/100 ✓ Peer-reviewed Risk factors Scholarly Review Journal

Key finding: This examination revealed higher incidences of breast cancer in Latinx and African American communities with high environmental exposures and lower socioeconomic statuses.

• Health Equity

Full summary, score breakdown and related studies → Original source

Alterations of the pulvinar in posterior cortical atrophy: A multimodal MRI study

50/100 ✓ Peer-reviewed Brain scans and imaging Cortex; a journal devoted to the study of the nervous system and behavior

Key finding: Cognitive and visual functions including visuospatial processing, visual perception, episodic memory, and naming were impaired among PCA patients. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

43/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: Both APPSAA-KI and hAβ-KI mice exhibit cognitive impairments, wherein no significant differences are found between these two models, although APPSAA KI mice show a trend towards worse cognitive function. +2 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study

63/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: In 320 patients, baseline plasma NfL levels were negatively associated with global cognition (β=-1.28 (-1.81 ; -0.75) P < 0.001), memory (β=-1.48 (-2.38 ; -0.59), P = 0.001), language (β=-1.72(-2.49 ; -0.95) P < 0.001), praxis (β=-2.02 (-2.91 ; -1.13) P < 0.001) and executive functions (β=-0.81, P < 0.001). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice

43/100 ✓ Peer-reviewed Genetics Heliyon

Key finding: APOE regulates brain lipid homeostasis and maintaining synaptic plasticity and neuronal function, where APOE2 has a superior function compared to APOE3 and APOE4. +3 more findings

• Genetics
• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Effect of a Financial Incentive Scheme for Medication Review on Polypharmacy in Elderly Inpatients With Dementia: A Retrospective Before-and-After Study

28/100 ✓ Peer-reviewed Health systems and care delivery Journal of patient safety

Key finding: No significant changes were observed in the average number of medication classes at discharge immediately after the introduction of the scheme (coefficient: -0.022, 95% confidence interval [CI]: -0.17 to 0.13). +2 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Nationwide Availability of and Enrollment in Medicare and Medicaid Dual-Eligible Special Needs Plans With Exclusively Aligned Enrollment

41/100 ✓ Peer-reviewed Risk factors JAMA Health Forum

Key finding: Of 2 197 732 beneficiaries enrolled in D-SNPs in 2021, 881 736 (40.1%) were living in counties with aligned enrollment available and 251 305 (11.4%) enrolled. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Social isolation and social cognition: A cross-sectional analysis

50/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

Key finding: No significant association was found between social isolation and ToM abilities for both the unadjusted and adjusted models. +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Cognitive reserve in individuals with frontotemporal dementia: a systematic review

82/100 ✓ Peer-reviewed Risk factors Journal of clinical and experimental neuropsychology

Key finding: Based on the included studies, partial support was demonstrated for CR in individuals with FTD when education, occupation, and leisure were utilized as CR proxies. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Should I stay or should I go again: Multiple switching between fee‐for‐service Medicare and Medicare advantage among older beneficiaries

38/100 ✓ Peer-reviewed Health systems and care delivery Health Services Research

Key finding: Overall, 3.3% of beneficiaries switched to MA annually. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

fMRI-based Alzheimer's disease detection via functional connectivity analysis: a systematic review

71/100 ✓ Peer-reviewed Brain scans and imaging PeerJ. Computer science

Key finding: Ultimately, the paper analyzed results on AD and highlighted future research directions in medical imaging.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Intervention Development for Tailored Education for Aging and Cognitive Health (TEACH) for Dementia Prevention in Midlife Adults: Protocol for a Randomized Controlled Trial

56/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: Study findings will reveal the feasibility of delivering an 8-week multidomain health education intervention for primary prevention of dementia in midlife and will provide preliminary evidence of mechanisms of change. +2 more findings

• Clinical Trials
• Prevention

Full summary, score breakdown and related studies → Original source

Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia

79/100 ✓ Peer-reviewed Biomarkers JAMA

Key finding: Plasma biomarkers of AD neuropathology, neuronal injury, and astrogliosis increase with age and are associated with known dementia risk factors. +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care

68/100 ✓ Peer-reviewed Biomarkers JAMA

Key finding: 1,213 patients with cognitive symptoms evaluated in Sweden, 2020-2024 +2 more findings

• Biomarkers
• Care Services

Full summary, score breakdown and related studies → Original source

Integrated multimodal cell atlas of Alzheimer's disease

65/100 ✓ Peer-reviewed How common it is Nature neuroscience

Key finding: Pseudoprogression analysis revealed two disease phases: an early phase with a slow increase in pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin + inhibitory neurons, and a remyelination response by oligodendrocyte precursor cells; and a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb + and Vip + inhibitory neuron subtypes. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Misfolded alpha synuclein co-occurrence with Alzheimer's disease proteinopathy

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology medRxiv : the preprint server for health sciences

Key finding: Syn positivity (synSAA+) co-occurred with T (in synSAA+ vs synSAA-, 36% vs 20% T+; p=0.011) and with cognitive impairment (10% vs 7% MCI; 10% vs 0% dementia; p=0.00050). synSAA+ participants' cognitive performance declined ∼40% faster than synSAA-for Digit Symbol, but not other tests. +2 more findings

• Brain Biology

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Semaglutide ameliorates Alzheimer's disease and restores oxytocin in APP/PS1 mice and human brain organoid models

43/100 ✓ Peer-reviewed Drug development Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: Behavioral analyses on APP/PS1 mice demonstrated that Semaglutide improved the cognitive capabilities, particularly in the learning and memory domains. +4 more findings

• Treatments
• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Head-to-head comparison of leading blood tests for Alzheimer's disease pathology

48/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: This study identified the plasma biomarker analytes and assays that most accurately classified amyloid pathology and other AD-related outcomes.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice

43/100 ✓ Peer-reviewed Brain scans and imaging Biomedical optics express

Key finding: OCT distinguished significant differences in retinal layer thickness between AD and WT animals.

• Brain Scans
• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve

55/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Significant interactions were found between APOE ε4 status and mindfulness and social engagement on cognitive reserve, indicating stronger associations for APOE ε4 carriers. +4 more findings

• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta

43/100 ✓ Peer-reviewed Genetics Fluids and barriers of the CNS

Key finding: Isogenic BMEC-like cells with different APOE genotypes had similar trans-endothelial electrical resistance, tight junction integrity and efflux transporter gene expression. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Intervention for the Management of Neuropsychiatric Symptoms to Reduce Caregiver Stress: Protocol for the Mindful and Self-Compassion Care Intervention for Caregivers of Persons Living With Dementia

58/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: Phase 3 (NIH stage 1B) is a feasibility randomized controlled trial of the intervention versus the Health Education Program control. +1 more finding

• Clinical Trials
• Caregiving

Full summary, score breakdown and related studies → Original source

Advances in Blood Biomarkers and Diagnosis Approaches for Neurodegenerative Dementias and Related Diseases

43/100 ✓ Peer-reviewed Biomarkers Journal of integrative neuroscience

Key finding: Degenerative proteins begin to accumulate before the onset of the symptoms of these diseases, and the early detection of these symptoms can lead to early therapeutic intervention. +4 more findings

• Biomarkers
• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease

67/100 ✓ Peer-reviewed Biomarkers Molecular neurodegeneration

Key finding: Our results demonstrate the feasibility and potential of immunoassay-based multiplexing to provide a comprehensive view of AD-associated proteomic changes, consistent with the recently revised biological and diagnostic framework. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source