Newest studies

Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period

43/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: YKL-40 associations with FW and FW-corrected fractional anisotropy were null. +3 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease

56/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: While the pathogenesis of SVD remains unclear, emerging evidence suggests that waste clearance involving perivascular space (PVS) - also known as the glymphatic system - dysfunction may play a role.

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Demographic, Health, and Social Predictors of Place of Death in England, 2004-2013: Identifying barriers to dying in the community

47/100 ✓ Peer-reviewed End-of-life care Journal of Aging & Social Policy

Key finding: Dementia is a barrier to dying in a private home, while it is associated with a care home death. +1 more finding

• End-of-Life Care

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Caring Under Pressure: Perceived Stress Among Caregivers of Dementia Patients

46/100 ✓ Peer-reviewed Clinical safety European Psychiatry

Key finding: The review consistently identified high levels of perceived stress among dementia caregivers. +4 more findings

• Caregiving

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Using a collaborative approach to reduce falls in older people’s adult mental health wards in a local health board in Wales

33/100 ✓ Peer-reviewed Clinical safety BMJ Open Quality

Key finding: Research has shown that falls can be reduced by 20%-30% through multifactorial assessments and interventions.

• Risk Factors

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Marchiafava-Bignami or delirium ipoactive: a case report presentation

31/100 ✓ Peer-reviewed Clinical safety Minerva Psychiatry

Key finding: It is often associated with malnutrition and alcoholism. +3 more findings

• Brain Scans

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Delirium in Elderly Hospitalized Patients: Analyzing Clinical and Social Determinants in a Colombian Retrospective Cohort

45/100 ✓ Peer-reviewed Clinical safety International Journal of Geriatric Psychiatry

Key finding: The studied cohort comprised 4601 patients, mean age of 83.93 years and 56.26% were women. +4 more findings

• Health Equity

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Scoping review exploring the impact of hip fracture in older adults with cognitive impairment or dementia

60/100 ✓ Peer-reviewed Clinical safety BMJ Open

Key finding: We identified 30 studies reporting health outcomes following hip fracture. +4 more findings

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SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementia in Chinese nursing homes

55/100 ✓ Peer-reviewed Prevention trials BMJ Open

Key finding: This disease is associated with numerous restrictions for those affected but also for caregivers and society. +1 more finding

• Clinical Trials

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A 12-week app-based multidomain intervention ameliorates cognitive performance in patients with mild cognitive impairment: preliminary results of the MEMODIO_APP@CARE RCT

40/100 ✓ Peer-reviewed Prevention trials European Psychiatry

Key finding: For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42). +4 more findings

• Early Stage
• Digital Tools

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A comparative study of the EAT‐Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance

60/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

Key finding: In multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance. +4 more findings

• Lifestyle
• Brain Scans

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Growth associated protein 43 (GAP-43) predicts brain amyloidosis in Alzheimer’s dementia continuum: an [18 F] AV-45 study

43/100 ✓ Peer-reviewed Disease mechanisms BMC Neurology

Key finding: Our findings revealed significantly elevated CSF GAP-43 levels in individuals with AD compared to CN and MCI groups. +3 more findings

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The Auditory Brainstem Response Diagnoses Alzheimer-Like Disease in the 5xFAD Mouse Model

34/100 ✓ Peer-reviewed Inflammation and the immune system eNeuro

Key finding: Significant difficulties in auditory processing have been frequently reported in many patients with mild cognitive impairment, the prodromal form of AD ( Tarawneh et al., 2022), making it an outstanding candidate as AD diagnostic biomarker. +2 more findings

• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia

47/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Our results elucidate the characteristics and genetic associations of p‐tau217 in a population‐based setting. +3 more findings

• Genetics

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Liver Diseases and Brain Disorders: Genetic Mechanisms and Biomarker Pathways in a Prospective Cohort Study From the UK Biobank

54/100 ✓ Peer-reviewed Long-term cohort studies Journal of Neurochemistry

Key finding: During a median follow-up of 14.46 years, participants with ALD, NAFLD, and VH demonstrated poorer cognition, mental health, and motor function compared to the healthy group, with p < 0.05 for false discovery rate (FDR-Q < 0.05). +1 more finding

• Genetics
• Biomarkers

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The impact of mild cognitive impairment on healthcare utilization and costs: A UK Biobank study

49/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Key finding: Of 164,508 eligible participants, 6605(4%) had cognitive testing scores consistent with MCI. +4 more findings

• Early Stage
• Policy

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Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study

48/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer s & Dementia

Key finding: Long sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024). +4 more findings

• Lifestyle

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Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia

37/100 ✓ Peer-reviewed Cognitive tests and assessment Quantitative Imaging in Medicine and Surgery

Key finding: Both V3 width and plasma Hcy concentration were negatively correlated with MoCA scores in PD (r=-0.358, P<0.001; r=-0.187, P=0.013, respectively). +4 more findings

• Early Stage

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Intersection of pain and behavioural and psychological symptoms of dementia in Alzheimer's disease

34/100 ✓ Peer-reviewed Cognitive tests and assessment Psychogeriatrics

Key finding: The median age of the participants was 69 years, with a median MMSE score of 16. +4 more findings

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Hippocampal Volume Loss as A Marker of Cognitive Decline in Dementia and Mild Cognitive Impairment: A Comprehensive Prospective Study

38/100 ✓ Peer-reviewed Cognitive tests and assessment National Journal of Medical Research

Key finding: The mean hippocampal volumes were significantly smaller in the DEM group compared to the MCI and healthy groups (P <0.0001). +4 more findings

• Diagnosis
• Brain Scans
• Early Stage

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Deciding on genetic testing for familial dementia: Perspectives of patients and families

42/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s & Dementia

Key finding: Of 138 (27%) eligible patients (46% female, age 61 ± 8 years, Mini-Mental State Examination [MMSE] 22 ± 6), 75 (54%) underwent genetic testing. +4 more findings

• Diagnosis
• Genetics
• Caregiving

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Molecular dynamics of amyloid-β transport in Alzheimer's disease: Exploring therapeutic plasma exchange with albumin replacement – Current insights and future perspectives

39/100 ✓ Peer-reviewed Tau biomarkers Neurología (English Edition)

Key finding: The first search utilized the following MeSH terms and keywords: ‘Plasma Exchange’, ‘Plasmapheresis’, ‘Therapeutic plasma exchange’, ‘Apheresis’, ‘Aβ’, ‘p-tau’, ‘Total-tau’, ‘Alzheimer's disease’, ‘Cognitive dysfunction’, ‘neurodegenerative diseases’, ‘centrifugation’, ‘membranous’, and ‘filtration’ in the Title/Abstract, yielding 146 results. +1 more finding

• Treatments

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Clinical evaluation of medicines for patients with mild cognitive impairment and mild dementia due to Alzheimer's disease in Japan

30/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: Though biomarker assessments showed significant Aβ reduction for both anti-amyloid therapies, no direct correlation with clinical outcomes was observed, limiting their use as surrogate endpoints. +1 more finding

• Early Stage
• Treatments

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Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study

53/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: In linear mixed models, vascular endothelial growth factor was significantly associated with incident DWI-positive lesions over 1 year. +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

A pilot randomized controlled double-blind trial of intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) to improve memory in mild cognitive impairment (MCI): a study protocol

48/100 ✓ Peer-reviewed Mild cognitive impairment Pilot and Feasibility Studies

Key finding: This innovative study aims to test the feasibility of iTBS as a cognitive enhancement strategy in MCI. +2 more findings

• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source