Newest studies

Dementia from Small Vessel Disease Versus Alzheimer’s Disease: Separate Diseases or Distinct Manifestations of Cerebral Capillopathy Due to Blood–Brain Barrier Dysfunction? A Pilot Study

36/100 ✓ Peer-reviewed Cognitive tests and assessment International Journal of Molecular Sciences

Key finding: Arterial perfusion demonstrated no statistical differences among SVD, AD, and controls, suggesting normal arterial flow. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Global incidence trends and projections of Alzheimer disease and other dementias: an age-period-cohort analysis 2021

48/100 ✓ Peer-reviewed Caregiving Journal of Global Health

Key finding: Between 1992-2021, global AD cases increased from 4.078 million to 9.837 million, while the global age-standardised incidence rate (ASIR) remained relatively stable, rising slightly from 117.7 to 119.8 per 100 000. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Challenges to accessing community dementia care services: a qualitative study

44/100 ✓ Peer-reviewed Caregiving BMC Health Services Research

Key finding: We synthesized caregivers' multiple challenges under five themes - (1) lack of information and awareness limit perceived need for services, (2) cultural norms and values influence decision to seek services, (3) complex processes and long waiting times hinder ability to reach services, (4) financial constraints and high costs force alternate care arrangements, and (5) inability to meet expectations and lack of family support limit engagement with services. +3 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Implementing early detection of cognitive impairment in primary care to improve care for older adults

51/100 ✓ Peer-reviewed Caregiving Journal of Internal Medicine

Key finding: Identifying risk factors early enables providers to implement interventions that can slow cognitive decline and improve outcomes for patients and caregivers. +4 more findings

• Diagnosis
• Care Services
• Health Equity

Full summary, score breakdown and related studies → Original source

Sodium benzoate, a D-amino acid oxidase inhibitor, improved short-term memory in patients with mild cognitive impairment in a randomized, double-blind, placebo-controlled clinical trial

57/100 ✓ Peer-reviewed Treatments Psychiatry and clinical neurosciences

Key finding: With the moderate sample size of the current study, treatment using sodium benzoate, a DAO inhibitor, showed promise in improving cognition, especially short-term memory, in patients with aMCI. +1 more finding

• Clinical Trials
• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

[Cerebrospinal Fluid Biomarker Profile in Atypical Alzheimer's Disease]

50/100 ✓ Peer-reviewed Tau biomarkers Revista de neurologia

Key finding: The study included 57 patients (54% female, mean age 67 years), of whom 41 met AD diagnostic criteria. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Telehealth Use by Home Health Agencies Before, During, and After COVID-19

37/100 ✓ Peer-reviewed Health systems and care delivery Health services research

Key finding: Patterns of adoption and discontinuation suggest that COVID-19 interrupted the innovation diffusion process of telehealth into home health.

• Care Services
• Digital Tools
• Policy

Full summary, score breakdown and related studies → Original source

Describing the elements of an effective dementia palliative care service

32/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: The logic model and summary results explain in detail how this dementia palliative care service undertook activities relating to person-centred care, carer support, end-of-life care, accessible care, timely care, and integrated care. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Reducing the cost of inpatient falls: An ERM perspective

29/100 ✓ Peer-reviewed Clinical safety Journal of Healthcare Risk Management

Key finding: The authors completed a comprehensive literature review and identified predictors of injuries from falls. +4 more findings

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Falls in people with Alzheimer’s disease: Exploring the role of inhibitory control

40/100 ✓ Peer-reviewed Clinical safety Neuroscience & Biobehavioral Reviews

Key finding: Thus, emerging evidence suggests that accurately assessing inhibitory control could not only improve falls risk predictions but also aid AD detection.

Full summary, score breakdown and related studies → Original source

Identifying RAGE inhibitors as potential therapeutics for Alzheimer’s disease via integrated in-silico approaches

45/100 ✓ Peer-reviewed Disease mechanisms Scientific Reports

Key finding: The per-residue decomposition analysis revealed that specific residues namely, GLY_20, ALA_21, LYS_39, GLU_50, LYS_52, ARG_98, GLN_100, LYS_110, ASN_112, and ARG_198 played a key role in the binding process. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease

45/100 ✓ Peer-reviewed Disease mechanisms Alzheimer s Research & Therapy

Key finding: CSF and plasma SNAP25 were positively correlated, but no correlation was observed for VAMP2 in these matrices. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Early and Late Fusion for Multimodal Aggression Prediction in Dementia Patients: A Comparative Analysis

38/100 ✓ Peer-reviewed Brain tissue and pathology Applied Sciences

Key finding: Aggression in patients with dementia poses significant caregiving and clinical issues. +4 more findings

Full summary, score breakdown and related studies → Original source

Healthy Cardiovascular Status Attenuates the Detrimental Association Between Osteosarcopenic Adiposity and Alzheimer's Disease‐Related Dementia: A UK Biobank Cohort Study

39/100 ✓ Peer-reviewed Long-term cohort studies Journal of the American Heart Association

Key finding: OSA components are positively associated with the risk of ADRD. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model

38/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer s Research & Therapy

Key finding: M07-TFN showed higher binding affinities and stronger activation of hTREM2 signaling than all previously described anti-hTREM2 antibodies. p-Syk activation was increased 30-fold in hTREM2-overexpressing HEK293 cells and fourfold in human microglia cells compared to baseline. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Digital Health Literacy and Physical Activity Programme for Improvement of Quality of Life in Caregivers of People with Dementia (CAREFIT): Study Protocol

32/100 ✓ Peer-reviewed Digital health tools Healthcare

Key finding: The proposed protocol for the CAREFIT programme represents an innovative and multidisciplinary initiative that leverages a digital platform to promote the well-being of informal caregivers of people with dementia. +2 more findings

• Digital Tools
• Caregiving

Full summary, score breakdown and related studies → Original source

Educational disparities in dementia incidence and healthcare utilization: evidence from a cohort study in Italy

48/100 ✓ Peer-reviewed Disparities Social Science & Medicine

Key finding: In a cohort of dementia-free 50-90-year-olds (907 453 men and 1 083 538 women), we found strong and age-patterned disparities in dementia incidence. +3 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Factors associated with receipt of caregiver training among family and unpaid caregivers of people living with dementia

42/100 ✓ Peer-reviewed Caregiving Aging and Health Research

Key finding: • Caregiver training helps dementia caregivers understand the disease and learn about caregiving skills. • Overall, about one in twelve informal dementia caregivers had taken any caregiving training. • Factors associated with the receipt of training included caregivers’ race, relationship, working status, and payer status, and care recipients’ level of assistance. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Multidisciplinary Home-Based Palliative Care for People Living with Dementia: Preliminary Findings on Palliative Care Concerns and Caregiver Burden

45/100 ✓ Peer-reviewed Caregiving Journal of Applied Gerontology

Key finding: Moderate levels of caregiver burden were reported at 31.57 (17.9), range 18–80 at baseline, which showed a slight increase at three months follow-up, though palliative care concerns significantly reduced (Cohen’s d = 1.16).

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments

47/100 ✓ Peer-reviewed TREM2 and immune genetics IBRO neuroscience reports

Key finding: Emerging evidence highlights the critical role of neuroinflammation, characterized by sustained activation of microglia and astrocytes, cytokine release, and inflammasome activation in accelerating AD progression. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

"Did I buy that just now?" – Investigating factors influencing the accuracy of food choice self-reports in a simulated online grocery store

44/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: Reporting accuracy significantly increased to 78 % with image-based memory aids for specific product categories (e.g., apples), and to 89 % with text-based memory aids for general categories (e.g., vegetables). +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

In-Home Assistive Technology May Help Protect Dementia Caregivers from Declining Sleep Efficiency: A Randomized Control Trial

42/100 ✓ Peer-reviewed Clinical safety Clinical Gerontologist

Key finding: Caregivers in the control conditions reported significantly worsening sleep efficiency whereas in comparison, those in the active conditions reported improving sleep efficiency. +3 more findings

• Digital Tools
• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Japan-multimodal intervention trial for the prevention of dementia in older people with lifestyle-related diseases: A community-based, 18-month, randomized controlled trial

53/100 ✓ Peer-reviewed Prevention trials Journal of Alzheimer s Disease

Key finding: This multimodal intervention program demonstrated no effectiveness in mitigating cognitive decline. +3 more findings

• Clinical Trials
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia

36/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Pharmacological Sciences

Key finding: Vascular dementia (VaD) is a leading cause of cognitive decline, closely associated with cerebrovascular endothelial cell (CEC) dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Performance of a smell identification test versus the Mini-Mental Status Exam for the detection of dementia and cognitive impairment among persons with cognitive concerns in primary care

48/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease

Key finding: The comparator test was the Mini Mental Status Exam II (MMSE). +4 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source