Home › Research › Getting a diagnosis
Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia
Yilong Zhao, Wen Fang Xing, Weiqi Chen, Yilong Wang. Frontiers in Immunology, 2025-03-24
Topic: Amyloid, tau and blood-test diagnosis
Results The results of gene set enrichment and gene set variation analyses indicated that immune-related pathways were upregulated in patients with VaD. According to GeneMANIA, VaD pathophysiology is strongly associated with immune and inflammatory responses. The mRNA expression of RAC1 and CMTM5 was significantly reduced in the BCAS group, which was consistent with the results of the integrated bioinformatics analysis. These findings pave the way for exploring novel molecular mechanisms aimed at preventing or treating VaD.
Key findings
- Results The results of gene set enrichment and gene set variation analyses indicated that immune-related pathways were upregulated in patients with VaD.
- According to GeneMANIA, VaD pathophysiology is strongly associated with immune and inflammatory responses.
- The mRNA expression of RAC1 and CMTM5 was significantly reduced in the BCAS group, which was consistent with the results of the integrated bioinformatics analysis.
- These findings pave the way for exploring novel molecular mechanisms aimed at preventing or treating VaD.
Why it matters
This bioinformatics and animal study found that immune-related pathways were upregulated in vascular dementia and that RAC1 and CMTM5 mRNA were reduced in a mouse model. The authors state these findings pave the way for exploring mechanisms, but no treatment or prevention is tested.
New to this subject? Start with our plain-English guide: Getting a diagnosis →
Study details
- Participants1,620
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Immunology) |
| Journal's citation record | 3 / 4 | Frontiers in Immunology: journal h-index 352 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,620 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Yilong Wang: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Chinese Academy of Sciences: institution h-index 1,801 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40196107) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fimmu.2025.1560438
- PubMed: 40196107
- Original source →
- Free full text: Frontiers in Immunology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Zhao, Y., Xing, W. F., Chen, W., & Wang, Y. (2025). Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2025.1560438
Vancouver
Zhao Y, Xing WF, Chen W, Wang Y. Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia. Frontiers in Immunology. 2025. doi:10.3389/fimmu.2025.1560438. PMID: 40196107.
BibTeX
@article{zhao2025-40196107,
author = {Zhao, Yilong and Xing, Wen Fang and Chen, Weiqi and Wang, Yilong},
title = {{Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia}},
journal = {Frontiers in Immunology},
year = {2025},
doi = {10.3389/fimmu.2025.1560438},
pmid = {40196107},
url = {https://doi.org/10.3389/fimmu.2025.1560438}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Related studies in Getting a diagnosis
Also tagged “cerebral”
900 studies in the library carry the topic tag “cerebral”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 900 tagged studies.