Newest studies

Impact of Sleep Disturbance on Dementia in Elderly Individuals: Sleep Disturbances and Dementia Risk

29/100 ✓ Peer-reviewed Risk factors Chronobiology in Medicine

Key finding: Sleep-related movement disorders (SRMDs) are associated with a 4-fold greater risk of incident all-cause dementia and an increased risk of VD than AD. +1 more finding

• Risk Factors
• Brain Biology
• Lifestyle

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Videoconference-Delivered Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Pilot Randomized Controlled Trial

59/100 ✓ Peer-reviewed Caregiving JMIR Formative Research

Key finding: The ACT group reported significantly greater improvements in stress (P=.043) and psychological QoL (P=.014) in the posttest compared to the control group. +4 more findings

• Clinical Trials
• Caregiving

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Cardiovascular Health Among Rural and Urban US Adults—Healthcare, Lifestyle, and Social Factors

63/100 ✓ Peer-reviewed Prevention and risk JAMA Cardiology

Key finding: The study population consisted of 27 172 adults, including 4256 adults (14.0%) residing in rural areas, 14 741 (54.8%) in small or medium metropolitan areas, and 8175 (31.2%) in urban areas. +4 more findings

• Risk Factors
• Health Equity
• Lifestyle

Full summary, score breakdown and related studies → Original source

Alzheimer mimicry: LATE and PART

37/100 ✓ Peer-reviewed Genetics Journal of Neural Transmission

Key finding: Clinical presentation and progression of SNAP can mimic AD which makes the final diagnosis and possible treatment uncertain in up to 30% of cases in clinical centers that are not using biomarkers. +4 more findings

• Genetics

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Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes

52/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: We investigated whether specific SLEs are associated with AD pathology and neurodegeneration and how these associations differ by gender and education. +3 more findings

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A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease

77/100 ✓ Peer-reviewed Digital health tools Nature medicine

Key finding: Overall, our findings underscore CSF YWHAG:NPTX2 as a robust prognostic biomarker for cognitive resilience versus AD onset and progression, highlight the potential of plasma proteomics in replacing CSF measurement and further implicate synapse dysfunction as a core driver of AD dementia.

• Biomarkers
• Brain Biology

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Structural and metabolic topological alterations associated with butylphthalide treatment in mild cognitive impairment: Data from a randomized, double-blind, placebo-controlled trial

56/100 ✓ Peer-reviewed Treatments Psychiatry and clinical neurosciences

Key finding: Butylphthalide may restore abnormal organization in structural networks of patients with MCI due to AD, and baseline network metrics could be predictive markers for therapeutic efficacy of butylphthalide. +3 more findings

• Treatments
• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

When life is lived with dignity and decline: integration of rehabilitation and palliation in dementia care – a case report

37/100 ✓ Peer-reviewed End-of-life care BMC Palliative Care

Key finding: Dagmarsminde's holistic care philosophy integrates rehabilitation, palliative care, and "Omsorg" to empower residents in expressing their identity and engaging in a meaningful community. +2 more findings

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Repulsive Guidance Molecule-A as a Therapeutic Target Across Neurological Disorders: An Update

40/100 ✓ Peer-reviewed Disease mechanisms International Journal of Molecular Sciences

Key finding: Repulsive guidance molecule-a (RGMa) has emerged as a significant therapeutic target in a variety of neurological disorders, including neurodegenerative diseases and acute conditions.

• Treatments
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Seizures in Cerebral Amyloid Angiopathy

33/100 ✓ Peer-reviewed Brain tissue and pathology Neurology Clinical Practice

Key finding: CAA may be encountered as an isolated pathology or with Alzheimer disease and has been demonstrated to be associated with an increased risk of seizures. +4 more findings

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Social interaction as a unique form of reward – Insights from healthy ageing and frontotemporal dementia

40/100 ✓ Peer-reviewed Lewy body dementia Neuroscience & Biobehavioral Reviews

Key finding: Contemporary theories of social interaction must account for such motivational shifts, addressing the enhancement of social processing in ageing and its decline in dementia. +4 more findings

• Other Dementias

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Machine learning algorithms and traditional statistical models for detection of dementia: a population-based study

41/100 ✓ Peer-reviewed Digital health tools Age and Ageing

Key finding: Of the 5200 participants (mean age = 71.0 years, 57.1% females), 302 (5.8%) were diagnosed with dementia. +4 more findings

• Digital Tools

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Advanced convolutional neural network with attention mechanism for Alzheimer's disease classification using MRI

46/100 ✓ Peer-reviewed Brain scans and imaging Computers in Biology and Medicine

Key finding: We have incorporated a detailed experimental evaluation of the MSB, demonstrating its superior performance in cranial debridement tasks compared to existing methods. +3 more findings

• Brain Scans
• Digital Tools

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The resilient power of CSR: Sustained risk reduction despite widespread ESG adoption

36/100 ✓ Peer-reviewed Prevention and risk Finance research letters

Key finding: These results have significant implications for firm valuation and investor decision making. • We prove the robustness of risk reduction by ESG across models and metrics. • Its persistence proves that the effect on firm value is conducted through risk. • Total risk is the best representation of the effect of CSR on firm value.

• Prevention

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Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies

56/100 ✓ Peer-reviewed Mild cognitive impairment Movement Disorders

Key finding: Baseline plasma NfL was associated with increased risk of dementia/death in the entire cohort. +3 more findings

• Biomarkers
• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia

50/100 ✓ Peer-reviewed Mild cognitive impairment EBioMedicine

Key finding: MEG 16-38Hz spectral power, particularly over parieto-occipital magnetometers, was significantly reduced in the AD progression group. +4 more findings

• Early Stage

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Predicting explainable dementia types with LLM-aided feature engineering

45/100 ✓ Peer-reviewed Digital health tools Bioinformatics

Key finding: This paper proposes a novel LLM-aided feature engineering approach that enhances interpretability by extracting clinically relevant features from the Oxford Textbook of Medicine. +2 more findings

• Digital Tools

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Gut Microbiota and Alzheimer Disease

43/100 ✓ Peer-reviewed Disease mechanisms Acta neurologica Taiwanica

Key finding: It has been suggested that the GMB could play a role in the onset of AD.

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Ethical challenges related to capacity, competence and autonomy in individuals with dementia

30/100 ✓ Peer-reviewed End-of-life care Acta bioethica

Key finding: Dementia is a syndrome characterised by the development of multiple cognitive deficits and behavioural changes that significantly interfere with various aspects of life.

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Small vessel disease contributions to acute delirium: a pilot feasibility MRI study

50/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: Mean age was 83.5 years (delirium 78.7 vs non-delirium 88.4); 13/20 were female; 17/20 had premorbid cognitive decline/impairment or dementia. +4 more findings

• Brain Scans

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A hospital-based special care unit for dementia decreased hospital readmission rates for behaviour while reducing rates of falls and occupational violence across medical wards

42/100 ✓ Peer-reviewed Clinical safety Age and Ageing

Key finding: 121 SCU admissions involved 107 unique patients. +4 more findings

• Care Services

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Neuroinflammation and progress in clinical trials for the treatment of Alzheimer’s disease and related dementias: An update

32/100 ✓ Peer-reviewed Inflammation and the immune system Innovative Medicines & Omics

Key finding: This drug is specifically designed to target and clear amyloid-beta (Aβ) plaques. +4 more findings

• Brain Biology
• Treatments
• Clinical Trials

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Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-κB pathway

41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer s Disease

Key finding: Furthermore, semaglutide robustly activated AMP-activated protein kinase (AMPK) and suppressed the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling cascade, thus reducing the Aβ deposition and dampening the inflammatory cascade.

• Brain Biology
• Treatments
• Digital Tools

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A stress-dependent TDP-43 SUMOylation program preserves neuronal function

48/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Neurodegeneration

Key finding: We therefore set out to understand how SUMOylation may regulate TDP-43 in health and disease. +4 more findings

• Brain Biology

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Tinnitus, noise exposure and the risk of dementia: a prospective cohort study based on UK biobank

40/100 ✓ Peer-reviewed Long-term cohort studies Age and Ageing

Key finding: During a median follow-up of 12.8 years, 2219 incident dementias were recorded. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source