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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Clinical safety

Topic: Risk, prevention and care in population studies

Sixteen of 30 cases with DLB pathology had no parkinsonism, which represented diverse nigral neurodegeneration. Regarding the scheme to estimate the likelihood of DLB syndrome, the prevalence of core clinical features excluding rapid eye movement sleep behavior disorder and probable DLB diagnosis were significantly higher in the high-likelihood group than in the low-likelihood group. Regarding the prodromal DLB subtypes, mild cognitive impairment (MCI) onset was identified in 60%, psychiatric onset in 20%, delirium onset in 10%, and motor onset in 10% of cases, and the proportion of psychiatric onset or delirium onset was significantly higher compared with those without DLB pathology. Coexistence of MCI and psychiatric symptoms was observed in 41.6% of the MCI-onset cases. Patients with psychiatric-onset cases were significantly younger at the onset, with a longer disease duration than those with MCI-onset cases. No differences were observed in other clinicopathological variables among the subtypes. The fourth Consortium pathological criteria for DLB were applicable in a psychiatric cohort. MCI-onset cases in conjunction with core clinical features is the main prodromal DLB subtype, and four cases exhibited isolated psychiatric symptoms for long-term duration.

Key findings

Sixteen of 30 cases with DLB pathology had no parkinsonism, which represented diverse nigral neurodegeneration.
Regarding the scheme to estimate the likelihood of DLB syndrome, the prevalence of core clinical features excluding rapid eye movement sleep behavior disorder and probable DLB diagnosis were significantly higher in the high-likelihood group than in the low-likelihood group.
Regarding the prodromal DLB subtypes, mild cognitive impairment (MCI) onset was identified in 60%, psychiatric onset in 20%, delirium onset in 10%, and motor onset in 10% of cases, and the proportion of psychiatric onset or delirium onset was significantly higher compared with those without DLB pathology.
Coexistence of MCI and psychiatric symptoms was observed in 41.6% of the MCI-onset cases.
Patients with psychiatric-onset cases were significantly younger at the onset, with a longer disease duration than those with MCI-onset cases.

Why it matters

This autopsy study found that the fourth Consortium pathological criteria for dementia with Lewy Bodies could be applied in a psychiatric cohort, and that many cases with DLB pathology had no parkinsonism. It concerns diagnosis and classification of dementia with Lewy Bodies, not treatment, cure or prevention of Alzheimer's disease.

Study details

Effect size41.6%
Evidence strengthModerate

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Psychiatry and Clinical Neurosciences)
Journal's citation record	1 / 4	Psychiatry and Clinical Neurosciences: journal h-index 120 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Masashi Ikeda: h-index 63 (OpenAlex, whole career)
Institution's track record	1 / 3	Nagoya University: institution h-index 758 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40162542)
Free to read	2 / 2	Free to read
Total	42 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Takeda, K., Fujishiro, H., Torii, Y., Sekiguchi, H., Arafuka, S., Habuchi, C., et al. (2025). Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals. Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.13814

Vancouver

Takeda K, Fujishiro H, Torii Y, Sekiguchi H, Arafuka S, Habuchi C, et al. Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals. Psychiatry and Clinical Neurosciences. 2025. doi:10.1111/pcn.13814. PMID: 40162542.

BibTeX

@article{takeda2025-40162542,
  author  = {Takeda, Kazuhiro and Fujishiro, Hiroshige and Torii, Youta and Sekiguchi, Hirotaka and Arafuka, Shusei and Habuchi, Chikako and Miwa, Ayako and Ozaki, Norio and others},
  title   = {{Validation of the neuropathological criteria of the fourth Consortium on dementia with Lewy Bodies in autopsy cases from psychiatric hospitals}},
  journal = {Psychiatry and Clinical Neurosciences},
  year    = {2025},
  doi     = {10.1111/pcn.13814},
  pmid    = {40162542},
  url     = {https://doi.org/10.1111/pcn.13814}
}

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