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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 17,276–17,300 of 27,380 studies, newest first · page 692 of 1096.

January 2015 25

  1. 2015-01-26

    The psychological and neurocognitive consequences of critical illness. A pragmatic review of current evidence

    ✓ Peer-reviewed Clinical safety Journal of the Intensive Care Society

    Key finding: Neuropsychological and cognitive consequences following anaesthesia and critical illness are significant.

    Full summary, score breakdown and related studies → Original source

  2. 2015-01-26

    A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

    Key finding: The dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene is located within the Down Syndrome (DS) critical region on chromosome 21 and is implicated in the generation of Tau and amyloid pathologies that are associated with the early onset Alzheimer's Disease (AD) observed in DS. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2015-01-23

    A practical algorithm for managing Alzheimer's disease: what, when, and why?

    ✓ Peer-reviewed Prevention trials Annals of clinical and translational neurology

    Key finding: Treatment choice (e.g., oral vs. transdermal) should be based on patient or caregiver preference, ease of use, tolerability, and cost. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-01-22

    Melatonin for Sleep Disorders and Cognition in Dementia

    ✓ Peer-reviewed Risk factors American Journal of Alzheimer's Disease & Other Dementias®

    Key finding: Conversely, cognitive function did not change significantly. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2015-01-22

    Pharmacokinetic drug–drug interaction study of ranolazine and metformin in subjects with type 2 diabetes mellitus

    ✓ Peer-reviewed Drug development Clinical Pharmacology in Drug Development

    Key finding: The potential for a drug–drug interaction was explored in two phase 1 clinical studies in subjects with T2DM to evaluate the pharmacokinetics and safety of metformin 1000 mg BID when administered with ranolazine 1000 mg BID ( Study 1 , N = 28) or ranolazine 500 mg BID ( Study 2 , N = 25) as compared to metformin alone. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2015-01-22

    A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

    ✓ Peer-reviewed TREM2 and immune genetics Cell reports

    Key finding: Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2015-01-22

    Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's Disease Neuroimaging Initiative

    ✓ Peer-reviewed Brain scans and imaging AJNR. American journal of neuroradiology

    Key finding: Prior MR imaging studies, primarily at 1.5T, established hippocampal atrophy as a biomarker for Alzheimer disease. 3T MR imaging offers a higher contrast and signal-to-noise ratio, yet distortions and intensity uniformity are harder to control. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-01-22

    Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

    ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

    Key finding: Key experiments using fibril-free AβO solutions demonstrated that while Aβ is essential for memory loss, the fibrillar Aβ in amyloid deposits is not the agent. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2015-01-22

    Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

    ✓ Peer-reviewed Genetics Neuron

    Key finding: Quantitative in silico 3D modeling revealed activated Aβ phagocytic microglia in APP/PS1(+)Il10(-/-) mice that restricted cerebral amyloidosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2015-01-21

    Amyloid PET imaging: applications beyond Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Clinical and translational imaging

    Key finding: Finally, the potential use of amyloid PET tracer accumulation in cerebral white matter (WM) as a marker of myelin is being investigated, leading to some promising results in patients with WM lesions and multiple sclerosis.

    Full summary, score breakdown and related studies → Original source

  11. 2015-01-21

    Confusion: delirium and dementia - a smartphone app to improve cognitive assessment

    ✓ Peer-reviewed Cognitive tests and assessment BMJ quality improvement reports

    Key finding: The results of the study suggest that the introduction of a smartphone app for junior doctors can improve performance in cognitive assessment of older people.

    Full summary, score breakdown and related studies → Original source

  12. 2015-01-21

    Common genetic variants influence human subcortical brain structures

    ✓ Peer-reviewed Hippocampus size on brain scans Nature

    Key finding: We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-01-20

    Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration

    ✓ Peer-reviewed Genetics EMBO Molecular Medicine

    Key finding: Age‐related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressive environment and chronic accumulation of mononuclear phagocytes (MPs). +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2015-01-20

    Family Caregiver's Perception of Alzheimer's disease and caregiving in Chinese culture

    ✓ Peer-reviewed Caregiving Social work in public health

    Key finding: The findings showed that all family caregivers thought the Chinese terminology of AD laonian chidai, brought discrimination to individuals with cognitive impairment.

    Full summary, score breakdown and related studies → Original source

  15. 2015-01-20

    Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

    ✓ Peer-reviewed Inflammation and the immune system Molecular neurobiology

    Key finding: Increasing evidence indicates that microglial activation in the central nervous system is heterogeneous, which can be categorized into two opposite types: M1 phenotype and M2 phenotype. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2015-01-20

    Edible mushrooms: improving human health and promoting quality life

    ✓ Peer-reviewed Prevention and risk International journal of microbiology

    Key finding: As a result of these properties, some mushroom extracts are used to promote human health and are found as dietary supplements.

    Full summary, score breakdown and related studies → Original source

  17. 2015-01-20

    Communication skills training in a nursing home: effects of a brief intervention on residents and nursing aides

    ✓ Peer-reviewed Digital health tools Clinical interventions in aging

    Key finding: These studies have shown that communication skills training can improve nursing aides' communication with nursing home residents. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2015-01-19

    Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene

    ✓ Peer-reviewed Genetics Clinical and Applied Thrombosis/Hemostasis

    Key finding: The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2015-01-15

    HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse

    ✓ Peer-reviewed Inflammation and the immune system Journal of Virology

    Key finding: Infection of microglia with the HIV-1 SF162 macrophage-tropic strain resulted in increased Beclin1 expression, accompanied by an increase of LC3 protein levels and accumulation of LC3 reporter RFP + GFP + (yellow) puncta, suggesting that HIV-1 infection triggers autophagosome formation without promoting protein degradation by the lysosome. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2015-01-15

    Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

    ✓ Peer-reviewed TREM2 and immune genetics FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: Microglial cyclooxygenase-2, microsomal PGE synthase, and PGE2 expression were increased 2- to 25-fold in both genotypes by TLR activators; however, this induction was significantly (P < 0.01) greater in TR APOE4/4 microglia with TLR3 and TLR4 activators.

    Full summary, score breakdown and related studies → Original source

  21. 2015-01-15

    Souvenaid reduces behavioral deficits and improves social cognition skills in frontotemporal dementia: a proof-of-concept study

    ✓ Peer-reviewed Disease mechanisms Neuro-degenerative diseases

    Key finding: Our results provide evidence of the potential of Souvenaid™ therapy for the treatment of behavioral disturbances and social cognition skills in FTD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2015-01-15

    Risk factors for sleep disturbances in older adults: Evidence from prospective studies

    ✓ Peer-reviewed Risk factors Sleep medicine reviews

    Key finding: In conclusion, prospective studies have identified female gender, depressed mood, and physical illness as general risk factors for future sleep disturbances in later life, although specific physiological pathways have not yet been established.

    Full summary, score breakdown and related studies → Original source

  23. 2015-01-15

    Tight glycemic control and use of hypoglycemic medications in older veterans with type 2 diabetes and comorbid dementia

    ✓ Peer-reviewed Disparities Diabetes care

    Key finding: Older adults with diabetes and dementia are at increased risk for hypoglycemia and other adverse events associated with tight glycemic control and are unlikely to experience long-term benefits. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2015-01-14

    SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

    ✓ Peer-reviewed Inflammation and the immune system The Journal of Neuroscience

    Key finding: We showed that SIRT1 is reduced with the aging of microglia and that microglial SIRT1 deficiency has a causative role in aging- or tau-mediated memory deficits via IL-1β upregulation in mice. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2015-01-14

    Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

    ✓ Peer-reviewed Treatments Alzheimer's & Dementia

    Key finding: Two‐hundred and sixteen only subjects were randomized across 28 French expert clinical sites. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →