Newest studies

Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trial

50/100 ✓ Peer-reviewed Treatments The Lancet regional health. Europe

Key finding: Clinical and experimental evidence suggest that dopaminergic transmission is impaired in FTD. +1 more finding

• Clinical Trials

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Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification

63/100 ✓ Peer-reviewed Getting a diagnosis Nature Communications

Key finding: Among 358 autopsied participants, the two-step workflow predicted brain LBP with high accuracy overall (94%), and within clinical subgroups (clinical parkinsonism=95%; clinical Alzheimer's disease [AD]=94%; clinically unimpaired [CU]=93%). +1 more finding

• Biomarkers
• Other Dementias

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Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition

83/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Significant study-site, specimen type, and batch effects were observed. +4 more findings

• Lifestyle
• Clinical Trials
• Genetics

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DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease

47/100 ✓ Peer-reviewed Vascular contributions Journal of Cerebral Blood Flow & Metabolism

Key finding: Cerebral small vessel disease (cSVD) is associated with vascular cognitive impairment, dementia, and stroke. +2 more findings

• Other Dementias
• Brain Scans
• Brain Biology

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From data to dialogue in setting research priorities for Lewy body dementia

32/100 ✓ Peer-reviewed End-of-life care npj Dementia

Key finding: By combining AI-assisted topic modelling and community engagement, this study aimed to advance the research landscape for Lewy body dementia (LBD).

• Other Dementias

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Integrated Roles of Systemic Diseases and Serum Biomarkers in the Incidence of Age‐Related Macular Degeneration: The UK Biobank Study

42/100 ✓ Peer-reviewed Long-term cohort studies Medicine Bulletin

Key finding: Major systemic diseases elevate AMD risk, compounded by comorbidities. +2 more findings

• Risk Factors
• Biomarkers

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A review of type 2 diabetes mellitus and cognitive impairment

44/100 ✓ Peer-reviewed Risk factors Frontiers in Endocrinology

Key finding: Accumulating evidence indicates that T2DM is linked to declines in multiple cognitive domains, which may progress to cognitive impairment or even dementia. +1 more finding

• Risk Factors

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Pilot Test of Aprendiendo Juntos/Learning Together Demonstrates Improved Self-Efficacy for Providing Care Among Latino Family Caregivers of Persons Living With Dementia

40/100 ✓ Peer-reviewed Caregiving Western Journal of Nursing Research

Key finding: Caregiver self-efficacy significantly improved in the IIG compared with the WLG ( P = .042) with a moderate effect size ( d = 0.64). +4 more findings

• Caregiving
• Health Equity

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Sex differences in clinical risk factors for Alzheimer's dementia patients with early-onset and late-onset

56/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Global Women s Health

Key finding: A multivariate analysis was also performed to predict specific risk factors associated with male and female EOAD and LOAD patients. +4 more findings

• Risk Factors

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Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial

69/100 ✓ Peer-reviewed Prevention and risk Nature Medicine

Key finding: MPF (%WC, −2.06 (95% confidence interval (CI), −2.99, −1.13) and UPF (%WC, −1.05 (95% CI, −1.98, −0.13)) resulted in weight loss, with significantly greater %WC on MPF (Δ%WC, −1.01 (95% CI, −1.87, −0.14), P = 0.024; Cohen’s d , −0.48 (95% CI, −0.91, −0.06)). +1 more finding

• Clinical Trials
• Lifestyle

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Investigating The Neuroprotective Role of Curcumin in Alzheimer's Disease Models

28/100 ✓ Peer-reviewed Treatments Journal of Pharmacology Genetics and Molecular Biology

Key finding: This review provides a comprehensive study on the neuroprotective effects of curcumin in the case of Alzheimer disease, its biochemical and pharmacological profile in its application regarding unique chemical content, bioactive compounds of curcumin, and pharmacokinetic constraints, like poor bioavailability. +4 more findings

• Treatments
• Brain Biology

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Alzheimer's disease transcriptional landscape in ex vivo human microglia

59/100 ✓ Peer-reviewed Laboratory science Nature Neuroscience

Key finding: We identified changes associated with multiple AD phenotypes, capturing the severity of dementia and neuropathological lesions. +1 more finding

• Brain Biology

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Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting

42/100 ✓ Peer-reviewed Inflammation and the immune system BMJ open

Key finding: Frontotemporal lobar degeneration (FTLD) is the second most common early-onset dementia. +2 more findings

• Brain Biology
• Biomarkers
• Brain Scans

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Probiotic Supplementation Improves the Clinical Measures of Cognition in Patients With Mild Cognitive Impairment

40/100 ✓ Peer-reviewed Mild cognitive impairment Cureus

Key finding: All studies but one demonstrated a statistically significant improvement in total cognitive test scores, while all studies showed a significant improvement over the placebo in at least one cognitive subdomain. +1 more finding

• Early Stage
• Clinical Trials

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Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration

46/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: HIGHLIGHTS: Diabetic retinopathy (DR, ocular disorder) and Alzheimer's disease (AD, cerebral disorder) share common molecular mechanisms, including oxidative stress, inflammation, and proteostasis dysfunction. +4 more findings

• Brain Biology
• Risk Factors

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Alzheimer's Disease: Treatment Challenges for the Future

43/100 ✓ Peer-reviewed Treatments Journal of neurochemistry

Key finding: The approvals of the first anti-amyloid antibodies for the treatment of Alzheimer's disease have changed both the clinical and research landscape for the disease. +3 more findings

• Treatments

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Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment

46/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: AD mice showed early decreases in NVC and bilateral connectivity (BC) in motor and cingulate cortex, and hypoconnectivity within the sensory-motor network. +4 more findings

• Treatments

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Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience

43/100 ✓ Peer-reviewed Genetics Cell

Key finding: These epigenomic stability dynamics are closely associated with cell-type proportion changes, glial cell-state transitions, and coordinated epigenomic and transcriptomic dysregulation linked to AD pathology, cognitive impairment, and cognitive resilience.

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Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Ms4a4a deficiency reduced steady-state Aβ levels and shortened its half-life in brain interstitial fluid. +4 more findings

• Brain Biology

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Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: HIGHLIGHTS: Neuroinflammation biomarkers, including glial fibrillary acidic protein (GFAP), triggering receptor expressed on myeloid cells 2 (TREM2)/sTREM2, and YKL-40, show strong clinical potential in Alzheimer's disease (AD). +4 more findings

• Brain Biology
• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Cognitive impairment and p-tau217 are high in a vascular patient cohort

50/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Twenty-nine percent of the cohort had Montreal Cognitive Assessment (MoCA) scores indicative of cognitive impairment or dementia after adjusting for age, sex, and education based on National Alzheimer's Coordinating Center normative data. +4 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

General practitioners’ perspective on timely interprofessional case conferences on non-cancer patients with palliative care needs: a qualitative study (KOPAL)

39/100 ✓ Peer-reviewed End-of-life care BMJ Open

Key finding: Interprofessional case conferences may lead to more awareness regarding gaps in primary palliative care, one's own care routines or a lack of psychosocial support. +4 more findings

• End-of-Life Care

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Physician-Related Gaps in Hospice Referral for Patients with Advanced Dementia

42/100 ✓ Peer-reviewed End-of-life care Clinical Interventions in Aging

Key finding: A total of 200 physicians participated in the study. +4 more findings

• End-of-Life Care

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From living well to dying well with dementia: The significance of an expanded understanding of loss for end-of-life care

30/100 ✓ Peer-reviewed End-of-life care Palliative Care and Social Practice

Key finding: Our analysis suggests that the current theoretical approaches to dementia care need to be thought of as dialectical in relation to the lived experiences of decline, dependency and loss. +1 more finding

• End-of-Life Care

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The risk of delirium or dementia‐related hospitalization among individuals living with dementia after long‐term care entry: A population‐based risk prediction model

49/100 ✓ Peer-reviewed Clinical safety Alzheimer s & Dementia

Key finding: Within 365 days, 5.2% (N = 10709) of individuals had a delirium or dementia-related hospitalization. +4 more findings

• Care Services

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