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Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study
Maison Abu Raya, Ehud Zeltzer, Ganna Blazhenets, Daniel R. Schonhaut, Isabel Elaine Allen, Marı́a C. Carrillo, Constantine G. Gatsonis, Lucy Hanna et al.. Alzheimer s & Dementia, 2025-05-01
Topic: Amyloid, tau and blood-test diagnosis
Females had higher rates of positive amyloid PET visual reads (63% vs. 59%, P < 0.001) and higher Centiloids (CLs; median 48.7 vs. 36.8, p < 0.001). On logistic regression, females had higher odds ratios (ORs) for positive amyloid PET (visual read OR 1.20, 95% confidence interval [CI]: 1.11-1.31; CL threshold-based OR 1.37, 95% CI: 1.26-1.49; both p < 0.001). Females with cognitive impairment showed higher amyloid PET positivity and greater amyloid burden. Further research is needed to explore mechanisms and treatment implications. HIGHLIGHTS: Females exhibited higher rates of amyloid positron emission tomography (PET) positivity and higher amyloid burden than males. These sex effects were found in patients with both mild cognitive impairment (MCI) and dementia. Females also had higher rates of dementia and amnestic MCI, while males had higher rates of non-amnestic MCI and more cholinesterase inhibitor use.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Raya, M. A., Zeltzer, E., Blazhenets, G., Schonhaut, D. R., Allen, I. E., Carrillo, M. C., et al. (2025). Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70304
Vancouver
Raya MA, Zeltzer E, Blazhenets G, Schonhaut DR, Allen IE, Carrillo MC, et al. Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70304. PMID: 40415175.
BibTeX
@article{raya2025-40415175,
author = {Raya, Maison Abu and Zeltzer, Ehud and Blazhenets, Ganna and Schonhaut, Daniel R. and Allen, Isabel Elaine and Carrillo, Marı́a C. and Gatsonis, Constantine G. and Hanna, Lucy and others},
title = {{Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70304},
pmid = {40415175},
url = {https://doi.org/10.1002/alz.70304}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Females had higher rates of positive amyloid PET visual reads (63% vs. 59%, P < 0.001) and higher Centiloids (CLs; median 48.7 vs. 36.8, p < 0.001).
- On logistic regression, females had higher odds ratios (ORs) for positive amyloid PET (visual read OR 1.20, 95% confidence interval [CI]: 1.11-1.31; CL threshold-based OR 1.37, 95% CI: 1.26-1.49; both p < 0.001).
- Females with cognitive impairment showed higher amyloid PET positivity and greater amyloid burden.
- Further research is needed to explore mechanisms and treatment implications.
- HIGHLIGHTS: Females exhibited higher rates of amyloid positron emission tomography (PET) positivity and higher amyloid burden than males.
Why it matters
In this large real-world sample, women with cognitive impairment were more likely than men to have a positive amyloid PET scan and greater amyloid burden. The authors state that further research is needed to explore the mechanisms and what this means for treatment.
Study details
- Participants10,361
- Effect sizeOR 1.20; OR 1.37
- Evidence strengthModerate
How this study scored 61/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 4 / 4 | 10,361 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 20 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 4 / 6 | Cited 12.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Gil D. Rabinovici: h-index 116 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40415175) |
| Free to read | 2 / 2 | Free to read |
| Total | 61 / 100 | — |
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