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Directionality bias underpins divergent spatiotemporal progression of Alzheimer‐related tauopathy in mouse models
Justin Torok, Christopher Mezias, Ashish Raj. Alzheimer s & Dementia, 2025-05-01
Topic: Amyloid, tau and blood-test diagnosis
Retrograde bias better predicted tau progression than anterograde bias, but our best-fitting biophysical models incorporate the mixed effects of both retrograde- and anterograde-directed spread, with notable tau-strain-specific differences. There was a nontrivial association between directionality bias and tau aggressiveness, with more virulent strains exhibiting less retrograde character. Our study implicates directional bias in tau transmission along fiber tracts as a general feature of tauopathy spread and a strong candidate for explaining for the diversity of spatiotemporal tau progression between conditions. HIGHLIGHTS: Connectome-based spread is a feature underpinning tauopathic diseases, including Alzheimer's Eleven mouse models of tauopathy across four studies were explored Mathematical models of retrograde and nondirectional spread performed better than anterograde Different mouse models of tauopathy exhibited distinct spread biases Retrograde-biased spread tended to be associated with less aggressive tau strains.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Torok, J., Mezias, C., & Raj, A. (2025). Directionality bias underpins divergent spatiotemporal progression of Alzheimer‐related tauopathy in mouse models. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70092
Vancouver
Torok J, Mezias C, Raj A. Directionality bias underpins divergent spatiotemporal progression of Alzheimer‐related tauopathy in mouse models. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70092. PMID: 40396482.
BibTeX
@article{torok2025-40396482,
author = {Torok, Justin and Mezias, Christopher and Raj, Ashish},
title = {{Directionality bias underpins divergent spatiotemporal progression of Alzheimer‐related tauopathy in mouse models}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70092},
pmid = {40396482},
url = {https://doi.org/10.1002/alz.70092}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Retrograde bias better predicted tau progression than anterograde bias, but our best-fitting biophysical models incorporate the mixed effects of both retrograde- and anterograde-directed spread, with notable tau-strain-specific differences.
- There was a nontrivial association between directionality bias and tau aggressiveness, with more virulent strains exhibiting less retrograde character.
- Our study implicates directional bias in tau transmission along fiber tracts as a general feature of tauopathy spread and a strong candidate for explaining for the diversity of spatiotemporal tau progression between conditions.
- HIGHLIGHTS: Connectome-based spread is a feature underpinning tauopathic diseases, including Alzheimer's Eleven mouse models of tauopathy across four studies were explored Mathematical models of retrograde and nondirectional spread performed better than anterograde Different mouse models of tauopathy exhibited distinct spread biases Retrograde-biased spread tended to be associated with less aggressive tau strains.
Why it matters
In eleven mouse models of tauopathy, mathematical models of retrograde and mixed-direction spread fit tau progression better than anterograde spread, with differences between tau strains. This is animal modeling work about how tau spreads, not a treatment or prevention for people.
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ashish Raj: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40396482) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
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