Newest studies

Caregiver burden for informal caregivers of patients with dementia: A systematic review

61/100 ✓ Peer-reviewed Caregiving International nursing review

Key finding: Factors of caregiver burden in regard to people with dementia living in the community were clarified in this review study. +1 more finding

• Caregiving

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NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

36/100 ✓ Peer-reviewed Risk factors Neurobiology of aging

Key finding: Our results showed that APP/PS1 mice had exacerbated cognition impairment and elevated Aβ levels at 5 months after paraquat exposure, and that WT mice had cognition impairment at 5 and 16 months after paraquat exposure. +1 more finding

• Brain Biology

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Hippocampal volume and functional connectivity changes during the female menstrual cycle

36/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage

Key finding: The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. +2 more findings

• Brain Scans

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Maintaining older brain functionality: A targeted review

36/100 ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews

Key finding: Brain plasticity and its role in brain adaptation to the process of aging is influenced by other changes as a result of co-morbidities, environmental factors, personality traits (psychosocial variables) and genetic and epigenetic factors.

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The function of RNA-binding proteins at the synapse: implications for neurodegeneration

40/100 ✓ Peer-reviewed Disease mechanisms Cellular and molecular life sciences : CMLS

Key finding: Synaptic proteins are often associated with disease neuropathology, but their role in synaptic loss is not fully understood.

• Brain Biology

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Motion perception deficit in Down Syndrome

32/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuropsychologia

Key finding: We performed sensitivity measurements to optic flow with Visual Evoked Potentials (VEP) and psychophysical techniques in a group of young DS participants with mild mental retardation and without significant Alzheimer's clinical symptoms. +3 more findings

• Down Syndrome

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Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

47/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: Neuropathologically, this suggests that microglial-mediated neurodegeneration may occur in the hippocampal formation in AD and is detectable by ultra-high resolution MRI.

• Brain Scans
• Brain Biology

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Cerebral perfusion in the predementia stages of Alzheimer's disease

53/100 ✓ Peer-reviewed Mild cognitive impairment European radiology

Key finding: Key points • Decreasing CBF relates to more advanced AD stages in all supratentorial regions. • The reduction of CBF does not reach a bottom level. • ASL-CBF has potential as a measure for disease progression in AD.

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Older Adults' Reasons for Using Technology while Aging in Place

39/100 ✓ Peer-reviewed Digital health tools Gerontology

Key finding: The level of technology use in the context of aging in place is influenced by six major themes: challenges in the domain of independent living; behavioral options; personal thoughts on technology use; influence of the social network; influence of organizations, and the role of the physical environment. +3 more findings

• Digital Tools

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TREM2 variants and risk of Alzheimer's disease: a meta-analysis

50/100 ✓ Peer-reviewed TREM2 and immune genetics Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Key finding: Recent studies show that heterozygous variant of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of Alzheimer's disease (AD) but with inconclusive results. +2 more findings

• Genetics
• Risk Factors

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Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences

43/100 ✓ Peer-reviewed Mild cognitive impairment Cortex; a journal devoted to the study of the nervous system and behavior

Key finding: Several studies have recently shown that basal ganglia (BG) deterioration leads to distinctive impairments in the domains of syntax, action verbs, and action semantics. +2 more findings

• Early Stage
• Other Dementias

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Altered cortical and subcortical local coherence in PTSD: evidence from resting-state fMRI

36/100 ✓ Peer-reviewed Brain scans and imaging Acta Radiologica

Key finding: Compared with the normal controls, PTSD patients showed increased local coherence in subcortical regions, including amygdala, hippocampus, thalamus, and putamen, and decreased local coherence in cortical regions, including medial prefrontal cortex and dorsolateral prefrontal cortex. +3 more findings

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Cost-Effectiveness of Florbetapir-PET in Alzheimer's Disease: A Spanish Societal Perspective

38/100 ✓ Peer-reviewed Costs and economics The journal of mental health policy and economics

Key finding: Adjunctive florbetapir-PET increased quality-adjusted life years (QALYs) by 0.008 years and increased costs by 36 compared to SCE alone (incremental cost-effectiveness ratio [ICER], 4,769). +4 more findings

• Policy
• Brain Scans

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Drug repositioning in Alzheimer's disease

38/100 ✓ Peer-reviewed Drug development Frontiers in bioscience (Scholar edition)

Key finding: Drug repositioning offers an innovative approach to drug discovery with great potential in the field of Alzheimer's Disease and dementia therapeutics. +4 more findings

• Treatments

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Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Disease

47/100 ✓ Peer-reviewed Digital health tools JAMA neurology

Key finding: Under normal conditions, vivid dream mentation combined with skeletal muscle paralysis characterizes rapid eye movement sleep. +4 more findings

• Treatments
• Other Dementias
• Lifestyle

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Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease

66/100 ✓ Peer-reviewed Digital health tools Medicine

Key finding: The adjusted hazard ratio of developing dementia (AD or PD) was 1.74 (95% confidence interval = 1.55-1.96) in patients with COPD compared with patients without COPD after adjusting for age, gender, and comorbidities. +1 more finding

• Risk Factors

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Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

36/100 ✓ Peer-reviewed Inflammation and the immune system Annals of translational medicine

Key finding: However, increasing evidences demonstrated that neuroinflammatory changes, including chronic microgliosis are key pathological components of AD. +1 more finding

• Brain Biology

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Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide

36/100 ✓ Peer-reviewed Drug development World journal of diabetes

Key finding: Furthermore, growing evidences suggest the occurrence of several commonalities between T2D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. +3 more findings

• Treatments
• Risk Factors

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Emerging links between type 2 diabetes and Alzheimer's disease

52/100 ✓ Peer-reviewed Drug development World journal of diabetes

Key finding: Type 2 diabetes mellitus and Alzheimer's disease are both associated with increasing age, and each increases the risk of development of the other. +1 more finding

• Risk Factors

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The case for rejecting the amyloid cascade hypothesis

40/100 ✓ Peer-reviewed Risk genes beyond APOE Nature neuroscience

Key finding: Nearly 20 years ago, with the combination of observations from biochemistry, neuropathology and genetics, a compelling hypothesis known as the amyloid cascade hypothesis was formulated. +4 more findings

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Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study

52/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: In patients with a discrepancy between CSF p-tau181 and CSF Aβ42, the assessment of Aβ 42/40 ratio led to a reliable biological conclusion in over 50% of cases that agreed with a clinician's diagnosis.

• Biomarkers

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Understanding and reducing disability in older adults following critical illness

36/100 ✓ Peer-reviewed Clinical safety Critical care medicine

Key finding: Older adults who survive critical illness have physical and cognitive declines resulting in disability at greater rates than hospitalized, noncritically ill and community dwelling older adults. +1 more finding

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Capillary dysfunction: its detection and causative role in dementias and stroke

40/100 ✓ Peer-reviewed Clinical safety Current neurology and neuroscience reports

Key finding: Reanalyses of the equations we traditionally use to describe the relation between CBF and tissue oxygenation suggest that capillary flow patterns are crucial for the efficient extraction of oxygen: without close capillary flow control, "functional shunts" tend to form and some of the blood's oxygen content in effect becomes inaccessible to tissue.

• Risk Factors

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Immune attack: the role of inflammation in Alzheimer disease

56/100 ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neuroscience

Key finding: However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. +2 more findings

• Brain Biology

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2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

69/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The initial study, ADNI-1, enrolled 400 subjects with early mild cognitive impairment (MCI), 200 with early AD, and 200 cognitively normal elderly controls. +3 more findings

• Early Stage

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