Newest studies

Machine learning approaches to racial/ethnic differences in social determinants of mild cognitive impairment and its progression to dementia in the All of Us Research Program

45/100 ✓ Peer-reviewed Digital health tools The Journals of Gerontology Series B

Key finding: MCI prevalence was comparable across groups (7.5%-8.0%), but progression to dementia varied (9.4% Black vs. 11.4% Other). +4 more findings

• Health Equity
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Economic evaluation of a digital health intervention for preventing dementia in Canadians with mild cognitive impairment

36/100 ✓ Peer-reviewed Digital health tools Frontiers in Public Health

Key finding: Dementia poses an on-going Canadian challenge due to an aging population, with cases projected to rise significantly by 2050. +3 more findings

• Digital Tools
• Policy
• Early Stage

Full summary, score breakdown and related studies → Original source

Age-Specific Control and Alzheimer Disease Reference Curves and z -Scores for Glial Fibrillary Acidic Protein in Blood

55/100 ✓ Peer-reviewed Biomarkers Clinical Chemistry

Key finding: AD exhibited elevated serum GFAP levels in comparison to control patients (P < 0.0001). +4 more findings

Full summary, score breakdown and related studies → Original source

Limbic Alzheimer's co-pathology in multiple system atrophy is associated with cognitive impairment and diagnostic inaccuracy

57/100 ✓ Peer-reviewed Brain tissue and pathology Acta neuropathologica

Key finding: Cognitive impairment (CDR scores) was associated with diffuse and compact Aβ plaques across all regions (r ≥ 0.24, p ≤ 0.015), p-tau pathology in CA1 and CA3 + 4 (r ≥ 0.32, p ≤ 0.020), and neuronal α-syn inclusions in the amygdala (r = 0.54, p < 0.001). +2 more findings

• Diagnosis
• Brain Biology

Full summary, score breakdown and related studies → Original source

Understanding Tau pathology: Insights from animal models

43/100 ✓ Peer-reviewed Drug development Zoological research

Key finding: The pathogenic cascade involves hyperphosphorylation, conformational changes, and aggregation into neurofibrillary tangles (NFTs), which are spatially and functionally linked to neuronal dysfunction, synaptic loss, and progressive cognitive and motor decline. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Proteostasis and Neuroinflammation in Alzheimer’s Disease

37/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Integrative Neuroscience

Key finding: Dysregulated proteostasis and neuroinflammation, though usually protective, contribute significantly to disease progression.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Bidirectional impact of dementia and aspiration pneumonia on cognitive decline in older adults: A retrospective cohort analysis

46/100 ✓ Peer-reviewed Cognitive tests and assessment Geriatrics and gerontology international/Geriatrics & gerontology international

Key finding: Among 500 dementia patients (mean age 78.3 ± 7.2 years), Kaplan-Meier analysis revealed significantly earlier pneumonia onset in severe dementia patients (log-rank P < 0.001), with Cox regression showing that severe dementia conferred triple the pneumonia risk (hazard ratio [HR] = 3.01, 95% confidence interval [CI]: 2.15-4.21) and that swallowing dysfunction independently increased the hazard ratio 3.45-fold (95% CI: 2.61-4.55); aspiration pneumonia accelerated cognitive decline (β = -2.35, 95% CI: -3.12 to -1.58). +3 more findings

Full summary, score breakdown and related studies → Original source

The role of sleep in dementia prevention: building the case for causality

38/100 ✓ Peer-reviewed Risk factors SLEEP

Key finding: Kening Jiang, Daniel D Callow, Adam P Spira; The Role of Sleep in Dementia Prevention: Building the Case for Causality, Sleep, , zsaf285, https://doi.org/1

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Global burden of Alzheimer’s disease and other dementias (1990–2021): inequality, frontier, and decomposition analysis

43/100 ✓ Peer-reviewed Disparities Frontiers in Aging Neuroscience

Key finding: Globally, ADOD incidence, prevalence, and mortality increased significantly between 1990 and 2021 (156.54%, 160.81%, and 194.39%, respectively). +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Added Value of Amyloid PET Quantification with the Centiloid Scale in Clinical Practice

43/100 ✓ Peer-reviewed Biomarkers American Journal of Neuroradiology

Key finding: Fifty-three scans (31.74%) were rated amyloid-positive by all readers, while 62 scans (37.13%) were rated as amyloid-negative by all readers. +4 more findings

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activation

43/100 ✓ Peer-reviewed Inflammation and the immune system Redox biology

Key finding: Microglia play a significant role in the development and progression of Alzheimer's disease (AD). +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer's Disease and HIV-Associated Neurocognitive Disorders

43/100 ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

Key finding: Central to these processes are microglia, the brain's resident immune cells, which normally maintain brain homeostasis by clearing amyloid-beta (Aβ) and other misfolded proteins through phagocytosis and receptor-mediated degradation. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hearing loss, plasma neurodegenerative biomarkers, and cognitive function: Independent and additive effects

59/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: Plasma biomarkers such as neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau-217 (Ptau217) have emerged as promising indicators of neurodegeneration and Alzheimer's disease (AD) pathology. +4 more findings

• Biomarkers
• Risk Factors

Full summary, score breakdown and related studies → Original source

Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients

44/100 ✓ Peer-reviewed Clinical safety International Journal of Molecular Sciences

Key finding: Its occurrence results in a poor prognosis. +4 more findings

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Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study

49/100 ✓ Peer-reviewed Clinical safety PLoS Medicine

Key finding: This was a retrospective analysis using nationally representative UK general practice population between 1998 and 2018, from electronic health records (Clinical Practice Research Datalink, CPRD, GOLD). +4 more findings

• Side Effects
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

A Drum-Based Serious Game for Physical and Cognitive Training in Older Adults: Development and Mixed Methods Usability Study

36/100 ✓ Peer-reviewed Prevention trials International Journal of Human-Computer Interaction

Key finding: Physical and cognitive decline significantly affects seniors’ quality of life. +3 more findings

Full summary, score breakdown and related studies → Original source

Outdoor physical activity, residential green spaces and the risk of dementia in the UK Biobank cohort

56/100 ✓ Peer-reviewed Long-term cohort studies Communications Medicine

Key finding: Outdoor activity is linked to lower dementia risk, particularly in those living in more accessible GS. +4 more findings

• Risk Factors
• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies

39/100 ✓ Peer-reviewed Lewy body dementia Pharmacological Research

Key finding: Frontotemporal dementia (FTD) encompasses a broad, clinically and neuropathologically diverse group of neurodegenerative disorders associated with changes in personality, behaviour, and/or language due to the progressive degeneration of the frontal and temporal lobes of the brain. +2 more findings

• Genetics
• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Antipsychotic prescriptions in people with dementia in primary care: a cohort study investigating adherence of dose and duration to UK clinical guidelines

56/100 ✓ Peer-reviewed How common it is The Lancet Psychiatry

Key finding: In our dataset search, we identified 108 910 people with a record indicating dementia at any time. +4 more findings

• Side Effects
• Care Services

Full summary, score breakdown and related studies → Original source

Associations of circulating c-reactive protein levels with central Alzheimer’s disease biomarkers

46/100 ✓ Peer-reviewed Genetics The Journal of Prevention of Alzheimer s Disease

Key finding: The mean (SD) age of participants was 70.57 (8.00) years, with 179 (42.9 %) females. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Storage-dependent variability in Alzheimer disease-related plasma biomarker results using the Fujirebio Lumipulse G1200 platform

39/100 ✓ Peer-reviewed Biomarkers Journal of Neuropathology & Experimental Neurology

Key finding: In contrast, pTau181 readings exhibited marked elevations in frozen samples, while pTau217 showed modest early fluctuations followed by significant decreases with prolonged storage. +2 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

mRNA vaccine platform demonstrates potent immunotherapeutic targeting of amyloid-β and tau pathologies in Alzheimer's disease

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: We developed an AD mRNA vaccine platform generating Aβ- and Tau-targeting candidates. +4 more findings

• Treatments
• Brain Biology
• Prevention

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Cerebral amyloid angiopathy: a narrative review

43/100 ✓ Peer-reviewed Drug development Frontiers in aging neuroscience

Key finding: It is commonly associated with cognitive decline, cerebral hemorrhage, and other neurological pathologies. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review

43/100 ✓ Peer-reviewed Drug development Cureus

Key finding: In conclusion, GLP-1 RAs are an intriguing multitarget treatment option for people with NDs, and future research should focus on optimizing treatment for clinical trials, evolved agonists that can penetrate the central nervous system (CNS), and combination therapies.

• Treatments

Full summary, score breakdown and related studies → Original source

Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria

61/100 ✓ Peer-reviewed Vascular contributions JAMA Neurology

Key finding: Three survey rounds included 49 to 54 participants that agreed on VasCog-2 diagnostic criteria for preclinical, mild, and major dementia levels of vascular cognitive impairment (under the overarching term VCID). +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source