Newest studies

Cerebral small vessel disease: The impact of glymphopathy and sleep disorders

47/100 ✓ Peer-reviewed Vascular contributions Journal of Cerebral Blood Flow & Metabolism

Key finding: CSVD is a major cause of stroke and dementia, yet its pathogenesis is not fully understood. +4 more findings

• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source

Dysphagia Symptoms Contribute to Greater Care Partner Burden in Neurodegenerative Disease

43/100 ✓ Peer-reviewed Clinical safety American Journal of Speech-Language Pathology

Key finding: Higher general burden was associated with female caregivers (β = −.19, p = .05), higher education (β = .16, p = .03), caring for someone with dementia (β = .36, p = .01), and greater dysphagia-related burden (β = .33, p = .01). +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

The impact of cognitive training and physical rehabilitation on activity and quality of life in elderly patients

29/100 ✓ Peer-reviewed Prevention trials Russian Journal of Geriatric Medicine

Key finding: With age, people experience a decline in cognitive and physical functions, which increases the risk of falls, loss of independence, and deterioration in quality of life. +3 more findings

• Lifestyle

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Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress

39/100 ✓ Peer-reviewed Inflammation and the immune system Inflammopharmacology

Key finding: Recent research suggested that sodium-glucose cotransporter-2 (SGLT-2) inhibitors can mitigate memory impairment linked to Alzheimer's disease and are now being explored for their cognitive benefits. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Common neuropathologic change drivers of hippocampal sclerosis of ageing

56/100 ✓ Peer-reviewed Brain tissue and pathology Brain

Key finding: The aetiology of HS-A is heterogeneous, but HS-A is strongly associated with limbic-predominant age-related TDP-43 encephalopathy NC (LATE-NC). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Analysis of the Prevalence of Mild Cognitive Impairment and its Influencing Factors in the Elderly Population in Huzhou City

40/100 ✓ Peer-reviewed Mild cognitive impairment Actas Españolas de Psiquiatría

Key finding: A total of 800 questionnaires were sent out in this survey, and 778 were effectively collected, with an effective recovery rate of 97.25%. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Top-funded digital health companies offering lifestyle interventions for dementia prevention: Company overview and evidence analysis

48/100 ✓ Peer-reviewed Digital health tools PLoS ONE

Key finding: The ten top-funded companies offering DDLS received a total funding of EUR 128.52 million, of which three companies collected more than 75%. +3 more findings

• Digital Tools
• Prevention

Full summary, score breakdown and related studies → Original source

A re-evaluation study and literature review on AD8 as a screening tool for dementia

44/100 ✓ Peer-reviewed Getting a diagnosis PLoS ONE

Key finding: Thirty-seven participants had a CDR of 0, 61 had a CDR of 0.5, and 20 had a CDR ≥ 1. +4 more findings

• Diagnosis

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Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes

33/100 ✓ Peer-reviewed Genetics Human Genetics and Genomics Advances

Key finding: We identified 138 LCS significant genes with false discovery rate (FDR) q <0.05, including 103 for β-amyloid, 24 for tangle density, and 25 for cognitive decline. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The fall-dementia connection: Synergistic effects of falls with genetic and health risk factors

40/100 ✓ Peer-reviewed Genetics Journal of Alzheimer s Disease

Key finding: Falls before dementia were linked to a higher risk of dementia. +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Perspectivas futuras do tratamento farmacológico para doença de Alzheimer: uma revisão integrativa

29/100 ✓ Peer-reviewed Genetics Revista JRG de Estudos Acadêmicos

Key finding: Para isso, foi realizada uma revisão integrativa da literatura com 38 artigos publicados entre 2020 e 2025, selecionados nas bases de dados Scientific Library Online (Scielo), PubMed e Biblioteca Virtual de Saúde (BVS). +4 more findings

Full summary, score breakdown and related studies → Original source

Older adults living with dementia enrolled in similar Medicare Advantage plans compared to those without dementia

32/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: There were few differences in how MA plan characteristics affected choice among older adults with and without dementia. +1 more finding

• Policy

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Disparities in neighborhood food environment and cognitive decline among US older adults: a cohort study

60/100 ✓ Peer-reviewed Risk factors BMC Medicine

Key finding: The mean age of participants was 77.1 years (SD = 7.6), and 2779 were women (weighted % = 56.7). +3 more findings

• Health Equity

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Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms

43/100 ✓ Peer-reviewed Risk factors Immunity

Key finding: Despite affecting cognition vs. vision, AD and AMD share neuroinflammatory pathways. +4 more findings

Full summary, score breakdown and related studies → Original source

PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease

42/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: We have demonstrated that activation of PINK1 (PTEN induced kinase 1)-dependent mitophagy ameliorates amyloid pathology, attenuates mitochondrial and synaptic dysfunction, and improves cognitive function. +1 more finding

• Brain Biology

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Association between visual hallucinations and cognitive performance in Lewy body dementia and Alzheimer's disease: A cross-sectional study

38/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer s Disease Reports

Key finding: DLB patients had a higher prevalence of VH than AD patients (p < 0.01). +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Temporal impact of sepsis on Alzheimer's disease pathology and neuroinflammation

38/100 ✓ Peer-reviewed Inflammation and the immune system Progress in Neurobiology

Key finding: Epidemiological evidence has revealed an associative link between sepsis survivorship and increased risk of dementia, particularly Alzheimer's disease (AD). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13-Year Longitudinal Cohort Study

52/100 ✓ Peer-reviewed Risk factors Journal of the American Heart Association

Key finding: Over 13 years, 65 336 patients with FCMD were identified, with 2584 developing dementia and 10 664 dying. +3 more findings

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Implementing a transmural model of early palliative care in advanced dementia: the use of a hybrid effectiveness-implementation study design

38/100 ✓ Peer-reviewed End-of-life care BMC Geriatrics

Key finding: The implementation of a transmural model of early palliative care for patients with advanced dementia requires the coordination between clinicians in the tertiary care setting and community, together with health information technologists. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer’s disease and corticobasal syndrome

49/100 ✓ Peer-reviewed Inflammation and the immune system European Archives of Psychiatry and Clinical Neuroscience

Key finding: In AD cases, pTau181 and ApoE4 levels were elevated, and the Aβ1-42/1-40 ratio was reduced. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The relationship between dementia staging scales, cognitive-behavioral scales and functionality in patients with cognitive impairment

48/100 ✓ Peer-reviewed Cognitive tests and assessment PLoS ONE

Key finding: This study analyzed 871 patients with cognitive impairment, 69.8% of whom were having functional impairment. +4 more findings

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Effects of an integrated social-art intervention on cognitive and psychosocial outcomes among older adults with mild cognitive impairment in nursing homes: a mixed methods study

59/100 ✓ Peer-reviewed Mild cognitive impairment BMC Medicine

Key finding: Eighty older adults with MCI (median age 86.50 years) participated, with an average attendance rate of 86.25% in the intervention group. +4 more findings

• Clinical Trials
• Early Stage

Full summary, score breakdown and related studies → Original source

Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases

52/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica

Key finding: These results suggest that Lewy-body negative LRRK2-related PD is not associated with a lack of α-synuclein aggregation in neurons but rather a deficiency in the formation of inclusions.

• Other Dementias

Full summary, score breakdown and related studies → Original source

Undocumented Dementia Diagnosis During Skilled Home Health Care: Prevalence and Associated Factors

44/100 ✓ Peer-reviewed How common it is Journal of the American Geriatrics Society

Key finding: Among 1,372,570 HH patients, 30% had diagnosed dementia. +4 more findings

• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

The intersection of rurality and dementia prevalence in Australia for Aboriginal and Torres Strait Islander and non‐Indigenous peoples

52/100 ✓ Peer-reviewed Disparities The Medical Journal of Australia

Key finding: For non-Indigenous peoples, the crude and age-standardised (World Health Organization standard) prevalence of dementia was 10.6 and 7.4 per 1000 persons, respectively. +4 more findings

Full summary, score breakdown and related studies → Original source