Newest studies

Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum

66/100 ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

Key finding: We found that plasma p-tau217 was more associated with cognitive performance than p-tau181 and p-tau231 and that this relationship was particularly strong for memory scores (TRIAD: βp-tau217 = -0.53, βp-tau181 = -0.35 and βp-tau231 = -0.24; BioFINDER-2: βp-tau217 = -0.52, βp-tau181 = -0.24 and βp-tau231 = -0.29). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Two cases of Amyloid-Related Imaging Abnormalities (ARIA) following lecanemab treatment for alzheimer's disease and a literature review

50/100 ✓ Peer-reviewed Treatments BMC neurology

Key finding: During lecanemab treatment for AD, it is essential to fully understand the mechanisms, imaging characteristics, and management strategies of ARIA.

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Multi-omics integration reveals the role of N6-methyladenosine in epilepsy, ischemic stroke, and vascular dementia

34/100 ✓ Peer-reviewed Vascular contributions Molecular Brain

Key finding: We identified 218 m6A sites significantly associated with the three diseases, highlighting 3,430 associations between m6A sites and gene expression. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Cerebral markers of neuroinflammation and neurodegeneration in hypertensive disorders during pregnancy

28/100 ✓ Peer-reviewed Inflammation and the immune system Medical Immunology (Russia)

Key finding: Previous studies have shown that preeclampsia increases the risk of cerebrovascular and cardiovascular diseases, as well as cognitive impairments, up to evolving dementia in the future. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

40/100 ✓ Peer-reviewed Lewy body dementia Neurobiology of Disease

Key finding: In post-mortem brain tissue from patients with frontotemporal dementia due to heterozygous progranulin mutations, neutral, but not acidic, sphingomyelinase activity was decreased. +4 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank

52/100 ✓ Peer-reviewed Risk factors BMC Medicine

Key finding: There were 7458 incident all-cause dementia cases (1636 VaD, 3376 AD) after 4,165,352 person-years of follow-up. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Cognitive Dysfunction and Dementia in Type 2 Diabetes Mellitus: Insights into Mechanisms, Models, and Therapeutics

39/100 ✓ Peer-reviewed Risk factors ACS Pharmacology & Translational Science

Key finding: Emerging technologies, such as brain and vascular organoid models, have opened new avenues for unraveling these complexities, although significant challenges remain in translating these tools into clinical practice.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Machine learning-based prediction of short- and long-term mortality for shared decision-making in older hip fracture patients: the Dutch Hip Fracture Audit algorithms in 74,396 cases

59/100 ✓ Peer-reviewed Digital health tools Acta Orthopaedica

Key finding: 74,396 patients (median age 84, IQR 78-89; 68% female) were analyzed. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Associations of cardiometabolic multimorbidity with all-cause dementia, alzheimer’s disease, and vascular dementia: a cohort study in the UK biobank

56/100 ✓ Peer-reviewed How common it is BMC Public Health

Key finding: Compared with those without CMD, those with CMD multimorbidity had an elevated risk of ACD (hazard ratio [HR]: 2.27, 95% confidence interval [95% CI]: 1.95-2.63), AD (HR: 1.49, 95% CI: 1.13-1.97), and VD (HR: 3.70, 95% CI: 2.93-4.69). +4 more findings

Full summary, score breakdown and related studies → Original source

Neuropsychiatric Symptoms of Alzheimer Disease, Parkinson Disease and Lewy Body Dementia: Genetic, Clinical and Therapeutic Overlaps

28/100 ✓ Peer-reviewed Genetics Advances in Geriatric Medicine and Research

Key finding: Apolipoprotein E-4 (APOE-4), serotonin transporter gene (SLC6A4), and single nucleotide polymorphisms (SNPs) of glucocerebrosidase (GBA) are some of the main altered genes in AD, PDD and DLB. +4 more findings

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

62/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: This study included 887 +4 more findings

Full summary, score breakdown and related studies → Original source

Associations between U.S. county‐level social infrastructure and dementia among Medicare beneficiaries, 2020

32/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Behavior & Socioeconomics of Aging

Key finding: Higher densities of civic organizations were associated with lower county dementia incidence, while museums and recreational facilities were associated with lower prevalence and incidence. +4 more findings

Full summary, score breakdown and related studies → Original source

Enhanced cognitive performance in older adults through combined cognitive training and transcranial direct current stimulation

38/100 ✓ Peer-reviewed Prevention trials Scientific Reports

Key finding: Cognitive decline in older adults has significant implications for autonomy and quality of life. +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

The effect of modified donanemab titration on amyloid-related imaging abnormalities with edema/effusions and amyloid reduction: 18-month results from TRAILBLAZER-ALZ 6

69/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: The modified titration arm met the primary outcome and significantly reduced ARIA-E frequency compared with the standard dosing while maintaining a similar pharmacodynamic effect on amyloid reduction at 24 weeks. +4 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

Cost of Psychiatric Inpatient Treatment for Dementia in Switzerland: A Case-Level Analysis of Billing Data

40/100 ✓ Peer-reviewed Health systems and care delivery International journal of geriatric psychiatry

Key finding: Overall, cost homogeneity for total case cost as a proxy for the quality of the cost calculation was "satisfactory, sufficient" and did not show a clear trend towards improvement during the introduction of TARPSY.

• Policy
• Treatments

Full summary, score breakdown and related studies → Original source

The Role of Reminiscence in Arts-Based Interventions for Dementia Care: A Scoping Review

36/100 ✓ Peer-reviewed Clinical safety Dementia

Key finding: 1508 articles were retrieved and screened using pre-established inclusion criteria; 21 empirical articles were retained. +4 more findings

Full summary, score breakdown and related studies → Original source

Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies

16/100 ⚠ Preprint — not yet peer-reviewed Drug development bioRxiv

Key finding: In frontotemporal dementia (FTD) patient-derived neurons and JNPL3 tauopathy mice, both harboring the P301L tau mutation, 1D9-LIRΔTP53INP2 significantly reduced tau levels and improved motor function in mice. +1 more finding

• Treatments

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The expanding role of semaglutide: beyond glycemic control

43/100 ✓ Peer-reviewed Drug development Journal of diabetes and metabolic disorders

Key finding: Data from the SUSTAIN and PIONEER clinical trials demonstrate significant reductions in HbA1c, body weight, and major adverse cardiovascular events (MACE), firmly establishing semaglutide as a key agent in diabetes management. +2 more findings

• Treatments
• Side Effects
• Risk Factors

Full summary, score breakdown and related studies → Original source

Evaluation of Blood-Based Diagnostic Biomarkers for Canine Cognitive Dysfunction Syndrome

43/100 ✓ Peer-reviewed Biomarkers Animals : an open access journal from MDPI

Key finding: While Aβ40, Aβ42, and GFAP were not significantly associated with CDS stage, serum NfL levels were elevated (p < 0.05) across all questionnaires.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Is US residence a risk factor for Alzheimer's disease?

39/100 ✓ Peer-reviewed Health systems and care delivery Journal of Alzheimer's disease : JAD

Key finding: Reducing risk factors is a useful way to counteract diseases. +3 more findings

• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

41/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer s Research & Therapy

Key finding: Autophagic markers beclin 1, LC3II and p62, and lysosome-related marker cathepsin B, all upregulated in AD astrocytes, were significantly reduced, while autophagic flux was rescued, by stabilizing 20 nm-MERCS. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer’s disease in cerebrospinal fluid

39/100 ✓ Peer-reviewed Digital health tools Alzheimer s Research & Therapy

Key finding: Utilizing machine learning, we identify a 12-protein panel from cerebrospinal fluid proteomic datasets. +4 more findings

• Biomarkers
• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Incidence trends and age-period-cohort analysis of Alzheimer’s disease and other dementias in the world and China from 1990 to 2021: analyses based on the Global Burden of Disease Study 2021

37/100 ✓ Peer-reviewed How common it is Frontiers in Neurology

Key finding: From 1990 to 2021, the incidence, prevalence, and DALYs of ADOD have significantly risen both globally and in China, with the growth rates in China notably surpassing the global average. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study

56/100 ✓ Peer-reviewed How common it is Journal of the American Heart Association

Key finding: We found no significant difference in dementia incidence over a 20‐year follow‐up period compared with matched TIA‐free controls. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

RETRACTED: Revolutionizing medical imaging: A cutting-edge AI framework with vision transformers and perceiver IO for multi-disease diagnosis

16/100 ⚠ Retracted — do not rely on it Brain scans and imaging Computational Biology and Chemistry

Key finding: The integration of artificial intelligence in medical image classification has significantly advanced disease detection. +1 more finding

• Brain Scans
• Diagnosis
• Digital Tools

Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source