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Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments
Yao Qin, Jing Cui, Durong Chen, Hongjuan Han, Hongyan Cao, Rong Zhang, Hao Zhu, Meiling Zhang et al.. Alzheimer s & Dementia, 2025-05-01
Topic: Risk, prevention and care in population studies
The probability of reversion increased from 2% at baseline to a maximum of 8% by year 10 before gradual decline thereafter. For post-reversion, the probability of progression to MCI rose from 8% to 35.71% at Year 10 and subsequently stabilized. The instantaneous risk of MCI progressing was similar to the risk of re-progression to MCI for post-reversion. Post-reversion subjects remained at an increased risk of cognitive deterioration. HIGHLIGHTS: The instantaneous risk of MCI progressing to AD is similar to the risk of re-progression to MCI for post-reversion. The FMSM we developed effectively utilizes multiple longitudinal markers to reveal variable transition patterns between different cognitive states. Considering both spatiotemporal dimensions and sparse irregularities from longitudinal neuroimaging and neuropsychological scales, fMLFPCA and MVFPCA help to extract variation patterns, to capture detailed changes characterizing the multidimensional evolution patterns of MCI.
Key findings
- The probability of reversion increased from 2% at baseline to a maximum of 8% by year 10 before gradual decline thereafter.
- For post-reversion, the probability of progression to MCI rose from 8% to 35.71% at Year 10 and subsequently stabilized.
- The instantaneous risk of MCI progressing was similar to the risk of re-progression to MCI for post-reversion.
- Post-reversion subjects remained at an increased risk of cognitive deterioration.
- HIGHLIGHTS: The instantaneous risk of MCI progressing to AD is similar to the risk of re-progression to MCI for post-reversion.
Why it matters
This analysis found that some people with mild cognitive impairment revert to normal cognition, but those who revert remain at increased risk of cognitive deterioration and of progressing back to mild cognitive impairment. It describes patterns of transition between cognitive states rather than testing any treatment.
Study details
- Study designretrospective cohort
- Effect size35.71%
- Evidence strengthModerate
How this study scored 44/100
Published in a peer-reviewed journal, and it is a retrospective cohort study, reconstructed from past records. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A retrospective cohort study, reconstructed from past records |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Hongmei Yu: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Shanxi Medical University: institution h-index 258 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40387264) |
| Free to read | 2 / 2 | Free to read |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Qin, Y., Cui, J., Chen, D., Han, H., Cao, H., Zhang, R., et al. (2025). Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70263
Vancouver
Qin Y, Cui J, Chen D, Han H, Cao H, Zhang R, et al. Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70263. PMID: 40387264.
BibTeX
@article{qin2025-40387264,
author = {Qin, Yao and Cui, Jing and Chen, Durong and Han, Hongjuan and Cao, Hongyan and Zhang, Rong and Zhu, Hao and Zhang, Meiling and others},
title = {{Characterizing bidirectional transitions in mild cognitive impairment and post‐reversion based on longitudinal neuroimaging and cognitive assessments}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70263},
pmid = {40387264},
url = {https://doi.org/10.1002/alz.70263}
}
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