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Adverse Social Exposome During the Life Course and Vascular Brain Injury
Sarah A. Keller, Amanda DeWitt, W. Ryan Powell, Frederick B. Ketchum, Robert A. Rissman, Barbara B. Bendlin, Amy Kind. JAMA Network Open, 2025-05-27
Topic: Risk, prevention and care in population studies
The sample included 740 donors (417 female [56.4%]; mean [SD] age at death, 81.5 [10.3] years; mean [SD] VBI score, 0.7 [1.0]; and median life course ADI, 7.08 [IQR, 4.33-9.83]), with residential years spanning 1905 to 2018. In adjusted models, living more years in a county with an ADI ranked above the study population median was associated with increased VBI odds (adjusted odds ratio [AOR], 1.04; 95% CI, 1.03-1.05). Greater odds of VBI were identified in those with increasing ADI between youth and adulthood (AOR, 3.67; 95% CI, 3.65-3.70) and youth and older adulthood (AOR, 12.02; 95% CI, 7.87-18.35). Increased odds were found in groups with stable high median ADI from youth to adulthood (AOR, 3.08; 95% CI, 3.01-3.14) and youth to older adulthood (AOR, 8.46; 95% CI, 8.04-8.90). Conclusions and Relevance: In this cohort study of 740 brain bank donors, an association between ADI and the presence of VBI was indicated, when considering the full life course as well as specific life course periods. These results show promise for identifying geographic areas in need of targeted interventions to reduce cerebrovascular disease and ADRD risk factors.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Keller, S. A., DeWitt, A., Powell, W. R., Ketchum, F. B., Rissman, R. A., Bendlin, B. B., et al. (2025). Adverse Social Exposome During the Life Course and Vascular Brain Injury. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2025.12289
Vancouver
Keller SA, DeWitt A, Powell WR, Ketchum FB, Rissman RA, Bendlin BB, et al. Adverse Social Exposome During the Life Course and Vascular Brain Injury. JAMA Network Open. 2025. doi:10.1001/jamanetworkopen.2025.12289. PMID: 40423969.
BibTeX
@article{keller2025-40423969,
author = {Keller, Sarah A. and DeWitt, Amanda and Powell, W. Ryan and Ketchum, Frederick B. and Rissman, Robert A. and Bendlin, Barbara B. and Kind, Amy},
title = {{Adverse Social Exposome During the Life Course and Vascular Brain Injury}},
journal = {JAMA Network Open},
year = {2025},
doi = {10.1001/jamanetworkopen.2025.12289},
pmid = {40423969},
url = {https://doi.org/10.1001/jamanetworkopen.2025.12289}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The sample included 740 donors (417 female [56.4%]; mean [SD] age at death, 81.5 [10.3] years; mean [SD] VBI score, 0.7 [1.0]; and median life course ADI, 7.08 [IQR, 4.33-9.83]), with residential years spanning 1905 to 2018.
- In adjusted models, living more years in a county with an ADI ranked above the study population median was associated with increased VBI odds (adjusted odds ratio [AOR], 1.04; 95% CI, 1.03-1.05).
- Greater odds of VBI were identified in those with increasing ADI between youth and adulthood (AOR, 3.67; 95% CI, 3.65-3.70) and youth and older adulthood (AOR, 12.02; 95% CI, 7.87-18.35).
- Increased odds were found in groups with stable high median ADI from youth to adulthood (AOR, 3.08; 95% CI, 3.01-3.14) and youth to older adulthood (AOR, 8.46; 95% CI, 8.04-8.90).
- Conclusions and Relevance: In this cohort study of 740 brain bank donors, an association between ADI and the presence of VBI was indicated, when considering the full life course as well as specific life course periods.
Why it matters
In this study of brain bank donors, living more years in a more disadvantaged county, and increasing disadvantage over the life course, were linked to higher odds of vascular brain injury. It does not test any treatment, cure or prevention, but the authors say the results may help identify areas for targeted interventions to reduce cerebrovascular disease and dementia risk factors.
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Study details
- Study designcohort study
- Participants740
- Effect size56.4%
- Evidence strengthModerate
How this study scored 60/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Network Open) |
| Journal's citation record | 2 / 4 | JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 740 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Amy Kind: h-index 47 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Southern California: institution h-index 1,521 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40423969) |
| Free to read | 2 / 2 | Free to read |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamanetworkopen.2025.12289
- PubMed: 40423969
- Original source →
- Free full text: JAMA Network Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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