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Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease
Lili Li, Shiyin Li, Lei Cai, Xiaofeng Yang, Yifeng Feng, Liying Zhang, Xiaofei He, Mingyue Li. Behavioural brain research, 2025-05-23
Topic: Disease mechanisms in lab and animal studies
Alzheimer's disease (AD) is the primary cause of dementia in older individuals, exhibiting an increasing incidence worldwide. Endoplasmic reticulum (ER) quality control has been receiving attention in the pathology of AD. The accumulation of misfolded proteins in the ER will activates the unfolded protein response (UPR), leading to cellular apoptosis. Using a mouse model of 5xFAD, we found that physical exercise (PE) promoted the clearance of ER fragments and inhibited the ER stress via ER autophagy (ER - Phagy). As a result, physical exercise reduced Aβ deposition, inhibited the neuronal apoptosis, ameliorated the emotional and cognitive impairments. Mechanistically, these PE related effects may be linked to the increased FAM134B, an ER-Phagy receptor, by up-regulating neuronal progranulin (Pgrn). Recombinant Pgrn injection could mimic the protective effects of PE, whereas down-regulation of Pgrn could abolish the PE-associated protection. Our findings indicate that physical exercise, as a readily accessible lifestyle intervention, holds significant potential for preventing diseases related to the global aging population.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, L., Li, S., Cai, L., Yang, X., Feng, Y., Zhang, L., et al. (2025). Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease. Behavioural brain research. https://doi.org/10.1016/j.bbr.2025.115650
Vancouver
Li L, Li S, Cai L, Yang X, Feng Y, Zhang L, et al. Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease. Behavioural brain research. 2025. doi:10.1016/j.bbr.2025.115650. PMID: 40414310.
BibTeX
@article{li2025-40414310,
author = {Li, Lili and Li, Shiyin and Cai, Lei and Yang, Xiaofeng and Feng, Yifeng and Zhang, Liying and He, Xiaofei and Li, Mingyue},
title = {{Physical exercise mitigates the cognitive impairments by promoting ER-phagy in mice model of Alzheimer's disease}},
journal = {Behavioural brain research},
year = {2025},
doi = {10.1016/j.bbr.2025.115650},
pmid = {40414310},
url = {https://doi.org/10.1016/j.bbr.2025.115650}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Using a mouse model of 5xFAD, we found that physical exercise (PE) promoted the clearance of ER fragments and inhibited the ER stress via ER autophagy (ER - Phagy).
- As a result, physical exercise reduced Aβ deposition, inhibited the neuronal apoptosis, ameliorated the emotional and cognitive impairments.
- Our findings indicate that physical exercise, as a readily accessible lifestyle intervention, holds significant potential for preventing diseases related to the global aging population.
Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Behavioural brain research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40414310) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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