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51/100

✓ Peer-reviewed alzhub usefulness score 51 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

A total of 43,160 participants were included (mean [standard deviation] age, 64.2 [7.7] years, 53.1 % female). Multimorbidity was present among 14,339 (33.2 %) participants, and was associated with reduced grey matter volume, total brain volume, left hippocampal volume, increased cerebrovascular pathology as well as reduced domain-specific cognitive function. A strong dose-response relationship was observed with the increasing number of multimorbid conditions across these outcomes. A disease cluster driven by cardiometabolic conditions was consistently associated with poorer brain health across all outcomes. Disease clusters driven by respiratory, mental health and other conditions showed less consistent associations. Multimorbidity was strongly associated with poorer brain health, particularly within the cardiometabolic disease cluster. Given that UK Biobank participants are, on average, healthier than the general population, future studies in more diverse and representative cohorts would be valuable.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Abid, S. U. A., Calvin, C. M., Qureshi, D., Veldsman, M., Kuźma, E., & Littlejohns, T. J. (2025). Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank. The Journal of Prevention of Alzheimer s Disease. https://doi.org/10.1016/j.tjpad.2025.100208

Vancouver

Abid SUA, Calvin CM, Qureshi D, Veldsman M, Kuźma E, Littlejohns TJ. Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank. The Journal of Prevention of Alzheimer s Disease. 2025. doi:10.1016/j.tjpad.2025.100208. PMID: 40425445.

BibTeX

@article{abid2025-40425445,
  author  = {Abid, Shehab Uddin Al and Calvin, Catherine M. and Qureshi, Danial and Veldsman, Michele and Kuźma, Elżbieta and Littlejohns, Thomas J.},
  title   = {{Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100208},
  pmid    = {40425445},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100208}
}

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Key findings

A total of 43,160 participants were included (mean [standard deviation] age, 64.2 [7.7] years, 53.1 % female).
Multimorbidity was present among 14,339 (33.2 %) participants, and was associated with reduced grey matter volume, total brain volume, left hippocampal volume, increased cerebrovascular pathology as well as reduced domain-specific cognitive function.
A strong dose-response relationship was observed with the increasing number of multimorbid conditions across these outcomes.
A disease cluster driven by cardiometabolic conditions was consistently associated with poorer brain health across all outcomes.
Disease clusters driven by respiratory, mental health and other conditions showed less consistent associations.

Why it matters

In this cross-sectional UK Biobank study, having multiple long-term conditions was linked to reduced brain volumes and poorer cognitive function, with the strongest links for a cluster of cardiometabolic conditions. Because the study is cross-sectional, it cannot show whether treating these conditions would prevent dementia.

Study details

Study designcross-sectional
Participants43,160
Evidence strengthModerate

How this study scored 51/100

Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of Prevention of Alzheimer s Disease)
Journal's citation record	0 / 4	The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	4 / 4	43,160 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Thomas J. Littlejohns: h-index 33 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Oxford: institution h-index 2,205 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40425445)
Free to read	2 / 2	Free to read
Total	51 / 100	—

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