Newest studies

Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases

37/100 ✓ Peer-reviewed Disease mechanisms NeuroMolecular Medicine

Key finding: Our results show that SPAM-tau exhibits distinct and vigorous prion-like seeding properties, inducing the aggregation of human and murine tau homologues with the formation of amyloidogenic (Thioflavin S-positive) inclusions. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Hypertension and diabetes on cognitive impairment: a case–control study in China

56/100 ✓ Peer-reviewed Risk factors Alzheimer s Research & Therapy

Key finding: We found significant impacts of hypertension, diabetes and their comorbidity on cognitive impairment occurrence. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Enhanced Multi-Model Machine Learning-Based Dementia Detection Using a Data Enrichment Framework: Leveraging the Blessing of Dimensionality

34/100 ✓ Peer-reviewed Digital health tools Bioengineering

Key finding: The results revealed that all the models exhibited consistent performance improvements with the enriched dataset, affirming the value of dimensionality when guided by domain expertise.

• Digital Tools

Full summary, score breakdown and related studies → Original source

A novel risk factor for dementia: chronic microplastic exposure

41/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: However, microplastics-plastic particles smaller than 5 mm-represent an understudied component of environmental pollution that may significantly impact neurological health. +2 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Improving Early Detection of Dementia: Extra Trees-Based Classification Model Using Inter-Relation-Based Features and K-Means Synthetic Minority Oversampling Technique

35/100 ✓ Peer-reviewed Disparities Big Data and Cognitive Computing

Key finding: The performance of the proposed method was compared with that of Support Vector Machine, K-Nearest Neighbors, Artificial Neural Networks, Random Forest, and Gradient Boosting. +1 more finding

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cell-death pathways and tau-associated neuronal vulnerability in Alzheimer's disease

43/100 ✓ Peer-reviewed Genetics Cell reports

Key finding: Multiplexed immunohistochemistry and in situ hybridization (CBLN2 and LINC00507) validated the presence of the tau-vulnerable neuronal population and revealed a propensity of this population to bear tau pathology. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Efficacy of different digital interventions in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis

82/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of nursing studies

Key finding: A total of 57 articles were included in the review, including 3182 participants. +3 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Objective assessments for walking aid prescription in balance impairment and falls risk: a scoping review of current evidence

37/100 ✓ Peer-reviewed Clinical safety Disability and Rehabilitation Assistive Technology

Key finding: Fourteen studies were included in the scoping review from 11,492 citations. +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Sublingual Crushed Levodopa for Parkinson’s Disease Management of a Lewy Body Dementia Patient With Dysphagia: A Case Report

30/100 ✓ Peer-reviewed Clinical safety Cureus

Key finding: We present an 85-year-old Caucasian male with Lewy body dementia and parkinsonian symptoms, who presented to the emergency department with dysphagia and altered level of consciousness in the context of a urinary tract infection. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Association of motoric cognitive risk syndrome with falls in older adults: findings from three longitudinal studies

57/100 ✓ Peer-reviewed Clinical safety BMC Geriatrics

Key finding: Ultimately, 10,373 participants were included in the analysis. +4 more findings

Full summary, score breakdown and related studies → Original source

Temporal dynamics in the association between depression and dementia: an umbrella review and meta-analysis

73/100 ✓ Peer-reviewed Risk factors EClinicalMedicine

Key finding: Pooled HRs indicated depression present in late-life (HR 1.95, 95% CI: 1.68–2.26; I 2 = 77.5%) and midlife (HR 1.56, 95% CI: 1.12–2.18; I 2 = 97.5%) significantly increased risk of all-cause dementia. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Social isolation, loneliness, genetic risk, and incident dementia in people with type 2 diabetes mellitus: A population-based cohort study

54/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Social isolation and loneliness were associated with a greater risk for incident dementia among T2DM individuals, with differential explanatory factors. +2 more findings

• Risk Factors
• Lifestyle
• Genetics

Full summary, score breakdown and related studies → Original source

Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid

68/100 ✓ Peer-reviewed Treatments Neurology

Key finding: Higher tau levels are associated with the fastest decline in everyday functioning in the presence of elevated amyloid, and those accumulating more tau show a faster decline in everyday functioning. +2 more findings

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Lecanemab in clinical practice: real-world outcomes in early Alzheimer's disease

71/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Between July 2023 and January 2025, 169 patients were screened and 86 initiated lecanemab treatment. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Epidemiological Evidence on the Associations of Metal Exposure with Alzheimer’s Disease and Related Dementias Among Elderly Women

43/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Clinical Medicine

Key finding: We identified 34 epidemiological studies that met the inclusion criteria. +4 more findings

Full summary, score breakdown and related studies → Original source

Identifying syntactic biomarkers of cognitive impairment in Mandarin-speaking older adults by applying machine learning approaches across multiple speech tasks

38/100 ✓ Peer-reviewed Digital health tools Aphasiology

Key finding: The use of linguistic biomarkers for detecting cognitive decline and early stages of dementia has demonstrated great potential due to its low-cost and non-invasive nature, especially towards a large aging population. +2 more findings

• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

A multinational cohort study of trends in survival following dementia diagnosis

57/100 ✓ Peer-reviewed How common it is Communications Medicine

Key finding: Data from 1,272,495 individuals, with the mean age at diagnosis ranging from 76.8 years (South Korea) to 82.9 years (Germany), show that the overall median length of survival following recorded diagnosis ranges from 2.4 years (New Zealand) to 7.9 years (South Korea). +1 more finding

• Diagnosis

Full summary, score breakdown and related studies → Original source

Digital Dementia Education and Training for Informal Carers: A Scoping Review

39/100 ✓ Peer-reviewed Caregiving Journal of Clinical Nursing

Key finding: The findings revealed three core areas: (a) types of digital tools used, including online platforms, video conferencing, mobile applications and SMS services; (b) educational domains addressed, such as knowledge and skills, psychological support, communication and social interaction, and environmental and technological adaptation; and (c) implementation strategies and outcomes, highlighting personalisation, cultural sensitivity and technological adaptability, which improved knowledge, emotional well-being and carer self-efficacy. +4 more findings

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

67/100 ✓ Peer-reviewed Prevention and risk New England Journal of Medicine

Key finding: A total of 172 patients were included (86 each in the sotatercept and placebo groups). +4 more findings

• Clinical Trials
• Risk Factors

Full summary, score breakdown and related studies → Original source

Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France

32/100 ✓ Peer-reviewed Risk factors Aging and Health Research

Key finding: Unmet need for long-term care (LTC) could be associated with higher health care utilization and medical spending. +4 more findings

• Care Services
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Social Isolation, Loneliness, and Cognitive Health

43/100 ✓ Peer-reviewed Risk factors Clinics in geriatric medicine

Key finding: Social connectedness is important for maintaining cognitive function and cognitive health in older age. +2 more findings

• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

End-of Life Care Disparities Experienced by American Indian and Alaska Natives Peoples: An Analysis of Data from the 2019 Medicare Master Beneficiary Summary File

40/100 ✓ Peer-reviewed End-of-life care Journal of Palliative Medicine

Key finding: AI/AN patients at the end-of-life were more likely to be hospitalized and less likely to use hospice compared with their NHW counterparts. +3 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice

38/100 ✓ Peer-reviewed Brain tissue and pathology Acta Neuropathologica Communications

Key finding: Taken together, AAV-vector mediated TDP-43 overexpression in the hypothalamus leads to neuropathology with the development of metabolic dysfunction and apathy-like behavior. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy

50/100 ✓ Peer-reviewed Mild cognitive impairment npj Dementia

Key finding: Using survival analyses, we found that two second-generation epigenetic clocks, DNAmPhenoAge and DNAmGrimAge, predicted progression from cognitively normal aging to mild cognitive impairment or AD and worse longitudinal cognitive outcomes. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Sleep disturbances as risk factors for neurodegeneration later in life

44/100 ✓ Peer-reviewed Risk factors npj Dementia

Key finding: We found that sleep disorders were associated with risk of Alzheimer’s disease (AD), amyotrophic lateral sclerosis, dementia, Parkinson’s disease (PD), and vascular dementia in three national biobanks (hazard ratios from 1.3 (PD) to 5.11 (dementia)). +1 more finding

• Risk Factors
• Other Dementias
• Lifestyle

Full summary, score breakdown and related studies → Original source