Newest studies

Occupational position and complexity in relation to Black‐White cognitive disparities

37/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Black participants had low (vs high) OP, which predicted worse episodic memory and global cognition (4% to 7% mediated). +4 more findings

• Health Equity

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Enhancing care service utilization and reducing burden: the role of needs assessments for dementia caregivers in long-term care

48/100 ✓ Peer-reviewed Caregiving BMC Nursing

Key finding: The implementation of needs assessments was associated with increased long-term care (LTC) service utilization. +4 more findings

• Caregiving
• Care Services

Full summary, score breakdown and related studies → Original source

Dementia knowledge and caregiver burden among carers of older adults in rural eastern Uganda

50/100 ✓ Peer-reviewed Caregiving Alzheimer s & Dementia

Key finding: The prevalence of caregiver burden was 28.9%. +4 more findings

• Caregiving
• Health Equity

Full summary, score breakdown and related studies → Original source

Enhanced Deep Learning Framework for Precise MRI ‐Based Alzheimer's Disease Stage Classification

31/100 ✓ Peer-reviewed Brain scans and imaging Computational Intelligence

Key finding: Alzheimer's disease (AD) diagnosis using MRI scans must be very accurate since the subtle differences throughout the course of the disease are difficult to identify.

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Contextualization of Harmonized Cognitive Assessment Protocol (HCAP) in an aging population in rural low‐resource settings in Africa: Experiences and strategies adopted to optimize effective adaption of cognitive tests in Kenya

56/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia

Key finding: The rural setting presented unique challenges including: low literacy rates (60.1% of participants had no schooling), diverse language use (primarily Giriama and Swahili), limited infrastructure (e.g., 44.8% of households had electricity), restrictive cultural norms that influenced data collection (e.g., in-home interviews were often conducted outdoors with destructions). +4 more findings

• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Midlife cognitive testing in Africa: validity of the Harmonised Cognitive Assessment Protocol in the Kenya Life Panel Survey

58/100 ✓ Peer-reviewed Getting a diagnosis BMJ Open

Key finding: Fit of the models to the data was adequate for general cognitive performance (root mean squared error of approximation (RMSEA)=0.03; comparative fit index (CFI)=0.94; standardised root mean residual (SRMR)=0.05), language (RMSEA=0.02; CFI=0.95; SRMR=0.05) and good for memory (RMSEA=0.05; CFI=0.99; SRMR=0.02) and executive functioning (RMSEA=0.03; CFI=0.98; SRMR=0.03). +4 more findings

• Diagnosis

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Shared Mechanisms in Dementia and Depression: The Modulatory Role of Physical Exercise

42/100 ✓ Peer-reviewed Prevention and risk Journal of Neurochemistry

Key finding: Dementia and depression are two prevalent disorders that warrant significant attention due to their high prevalence and substantial contribution to the global burden of disease.

• Lifestyle

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Dementia risk reduction in China: Country‐specific estimates of modifiable risk factors and population attributable fractions (PAFs)

48/100 ✓ Peer-reviewed Prevention and risk Alzheimer s & Dementia

Key finding: The 12 risk factors account for 60.3% of dementia cases in China, including 14.0% in early life, 8.8% in midlife, and 37.5% in later life. +4 more findings

• Prevention
• Risk Factors

Full summary, score breakdown and related studies → Original source

Multimorbidity in dementia: Current perspectives and future challenges

50/100 ✓ Peer-reviewed Prevention and risk Alzheimer s & Dementia

Key finding: It is associated with cognitive and functional decline, reduced health-related quality of life, increased health-care use, and higher mortality.

• Risk Factors

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Time to routinely perform 4AT at the ‘front door’; evidence informing policy and practice

52/100 ✓ Peer-reviewed Risk factors Age and Ageing

Key finding: A positive 4AT (≥1) on admission demonstrated a sensitivity of 0.87 and specificity of 0.71 when compared to a clinical diagnosis of dementia. +2 more findings

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The Hidden Global Health Crisis of Omega-3 Deficiency

36/100 ✓ Peer-reviewed Risk factors Oncology Times

Key finding: Research has shown that approximately 85 percent of the world's countries are not receiving enough omega-3s.

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Multi-Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

44/100 ✓ Peer-reviewed Digital health tools Pharmacology research & perspectives

Key finding: MTDD offers key advantages, including pathway-level synergy, broader therapeutic scope, and potential for improved efficacy. +4 more findings

• Treatments
• Digital Tools
• Brain Biology

Full summary, score breakdown and related studies → Original source

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial

75/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: Among older adults at risk of cognitive decline and dementia, a structured, higher-intensity intervention had a statistically significant greater benefit on global cognition compared with an unstructured, self-guided intervention. +4 more findings

• Clinical Trials

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Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial

61/100 ✓ Peer-reviewed Treatments JAMA health forum

Key finding: Of 44 844 patients invited to the APT Webstudy, the mean (SD) age was 64.7 (10.1) years, 25 447 (56.8%) were women, 25 044 (55.8%) had Medicaid insurance, 11 347 (25.3%) were Hispanic/Latino, 9526 (21.2%) were non-Hispanic Asian, 6044 (13.5%) were non-Hispanic Black, and 12 109 (27%) were non-Hispanic White. +1 more finding

• Clinical Trials
• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

The Evolution of Randomized Clinical Trial Designs to Assess Therapeutics in Alzheimer Disease

55/100 ✓ Peer-reviewed Treatments JAMA network open

Key finding: A substantial difference in the type of therapeutics researched was observed, with anti-amyloid and anti-tau RCTs being more likely to be funded by the pharmaceutical industry compared with neurotransmitter or other RCTs (anti-amyloid or anti-tau, 68 of 71 [95.8%]; neurotransmitter, 52 of 69 [77.6%]; other, 33 of 52 [63.5%]). +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Understanding how plasma tau biomarkers are influenced by co-pathologies and comorbidities is crucial for their accurate implementation. +2 more findings

• Biomarkers
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Early microglial and astrocyte reactivity in preclinical Alzheimer's disease

51/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Our findings suggest that microglial and astrocyte reactivity, measured through fluid biomarkers, occur early and impact the amyloid cascade on the preclinical Alzheimer´s continuum. +3 more findings

• Brain Biology
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease

64/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Plasma p-tau217/Aβ42 had high accuracy to detect AD, with comparable performance across race. +1 more finding

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Validating remote cognitive tests in the Wisconsin Registry for Alzheimer's Prevention

63/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Correlations between in-person and T-COG scores were of moderate to large magnitude (Pearson r: 0.57 to 0.80, intraclass correlation coefficients: 0.52 to 0.79). +4 more findings

• Diagnosis

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Uptake of video telehealth in general practice: an Australian whole-of-population analysis

32/100 ✓ Peer-reviewed Health systems and care delivery BJGP open

Key finding: Socioeconomic disadvantage was modestly associated with lower use of video.

• Digital Tools

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Communication and end-of-life care in dementia: insights from a close family member working in healthcare

28/100 ✓ Peer-reviewed End-of-life care British Journal of Community Nursing

Key finding: Significant references to communication barriers already exist within the literature, relating to end-of-life conversations.

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

GLP-1 receptor agonists in delirium and encephalopathies: a neuroprotective scoping review

35/100 ✓ Peer-reviewed Clinical safety Discover Medicine

Key finding: GLP-1 RAs may offer neuroprotective benefits in patients with postoperative delirium and encephalopathies.. +2 more findings

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Decision making in frontotemporal dementia: neuropsychological and neuroimaging assessments

46/100 ✓ Peer-reviewed Lewy body dementia Frontiers in Neuroscience

Key finding: Frontotemporal dementia (FTD) is a neurodegenerative disorder primarily affecting the frontal and temporal lobes, leading to significant impairments in executive function, social behavior, and emotional regulation. +2 more findings

• Other Dementias
• Brain Scans

Full summary, score breakdown and related studies → Original source

Inequalities in the Duration and Lifetime Risk of Dementia in the United States

49/100 ✓ Peer-reviewed Disparities Demography

Key finding: We found a higher lifetime risk of dementia than found in earlier U.S. studies: 41.3% (CI: 39.3% to 43.2%) of those who died after age 70 had dementia assessed at six months before death. +2 more findings

• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down Syndrome

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: The role of APP overdose in cortical malformation and cognitive impairments in DS is unknown. +4 more findings

• Down Syndrome
• Genetics

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source