Newest studies

Brexpiprazole for treating agitation in different groups of people with Alzheimer’s dementia: a plain language summary

36/100 ✓ Peer-reviewed Clinical safety Neurodegenerative Disease Management

Key finding: In this summary, researchers combined information from two clinical studies to look at the effects of brexpiprazole in 13 different groups of people with Alzheimer’s dementia. +1 more finding

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

GLP-1 receptor agonists reduce dementia and Alzheimer disease risk in diabetic patients with CKD

46/100 ✓ Peer-reviewed Drug development Nephrology Dialysis Transplantation

Key finding: GLP-1RA use was associated with a significantly lower risk of dementia [hazard ratio (HR) 0.80, 95% confidence interval (CI) 0.71-0.91, P = .001] and Alzheimer's disease (HR 0.76, 95% CI 0.59-0.98, P = .033) compared with DPP4i use. +3 more findings

• Risk Factors
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Development and validation of the LateDem-Risk score to predict dementia incidence in the InveCe.Ab and Trelong Italian cohorts

44/100 ✓ Peer-reviewed How common it is Scientific Reports

Key finding: In the TRELONG cohort, the score remained significant (HR = 1.19; 95% CI 1.05–1.10; p = 0.008), though its predictive value decreased when adjusting for non-modifiable factors.

• Risk Factors

Full summary, score breakdown and related studies → Original source

Lecanemab for treatment of individuals with early Alzheimer's Disease (AD) who are apolipoprotein E ε4 (ApoE ε4) non-carriers or heterozygotes

83/100 ✓ Peer-reviewed Treatments The journal of prevention of Alzheimer's disease

Key finding: 1795 participants with early AD were enrolled in Clarity AD, of which 1521 were ApoE ε4 heterozygotes or non-carriers (85 %). +4 more findings

• Treatments
• Genetics
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Spatiotemporal transcriptomic profiling reveals upregulation of glycolysis pathway genes before overt tauopathy in the PS19 mouse model

44/100 ✓ Peer-reviewed Disease mechanisms Experimental & Molecular Medicine

Key finding: Our findings reveal that disease-associated microglia and astrocyte phenotypes emerge concurrently with phosphorylated tau accumulation across multiple brain regions. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Chronic caffeine consumption prevents obesity-induced cognitive and memory impairments by reducing neuroinflammation and enhancing neuronal activity in the hippocampus

41/100 ✓ Peer-reviewed Inflammation and the immune system Pharmacological Research

Key finding: HFHSu feeding promoted obesity, insulin resistance, and glucose intolerance, accompanied by impaired memory and cognition (reductions in Y-maze, NOR, and block test), increased anxiety (54.5 % time in EPM open arms), reduced hippocampal glutamatergic (41.1 % VGlut) and adenosinergic signaling (22.4 %, 11.1 %, 22.6 % in A1, A2A, A2B receptors), and elevated neuroinflammation (elevated GFAP, IBA-1, IL-6 receptor levels; altered microglial morphology) compared with control. +1 more finding

• Brain Biology
• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Multifunctional Tannins from Phyllanthus amarus Exhibit Disease-Modifying Activities Against Alzheimer's Pathogenesis: An In Vitro and In Vivo Investigation

26/100 ✓ Peer-reviewed Risk genes beyond APOE IJPAR JOURNAL

Key finding: Experimental data revealed substantial neuroprotective effects, including suppression of Aβ aggregation and mitigation of neuroinflammatory processes. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Family Caregiver Burden and Neuropsychiatric Symptoms in Japanese Community‐Dwelling People With Alzheimer's Disease: A Cross‐Sectional Study Using a Web‐Based Questionnaire

43/100 ✓ Peer-reviewed Caregiving Psychogeriatrics

Key finding: Family caregivers (n = 705) had a mean ± standard deviation (SD) age of 54.6 ± 11.5 years, 56.9% were male, and 84.0% cared for a parent or in-law with AD. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America

57/100 ✓ Peer-reviewed Biomarkers Nature Aging

Key finding: These findings indicate that plasma AT(N) biomarkers, combined with neuroimaging and clinical assessments, can enhance dementia diagnosis across diverse Latin American populations.

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Treatment Effects of Cholinesterase Inhibitors in Alzheimer’s Disease: a Causal Machine Learning Approach

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: A bstract INTRODUCTION Treatment response in Alzheimer’s disease (AD) varies substantially across patients, yet no validated frameworks exist to estimate heterogeneous treatment effects (HTE) from observational data while controlling for confounding bias. +1 more finding

• Treatments
• Digital Tools

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Performance at digital testing in Alzheimer’s Disease is predicted by selective disruption of microstructural integrity

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment medRxiv

Key finding: White matter microstructural abnormalities are increasingly found to be associated with cognitive impairment in Alzheimer’s Disease (AD). +4 more findings

• Digital Tools

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Anti-amyloid therapies and the transformation of Alzheimer's care pathways: early lessons from the frontline

47/100 ✓ Peer-reviewed Treatments The Lancet regional health. Europe

Key finding: Our early real-world experience highlights three critical domains. +4 more findings

• Treatments
• Care Services

Full summary, score breakdown and related studies → Original source

The Metabolome as a Readout for Adverse Social Exposome Influences on Human Health - A Roadmap for Modifiable Factors and Proactive Health

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv : the preprint server for health sciences

Key finding: Our results suggest that participants living in ASE have metabolic features often shown to predispose individuals to higher risks for cardiovascular diseases and cognitive decline, with impaired mitochondrial energetics, amino acid and lipid metabolism.

• Risk Factors
• Prevention

Scored 28 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Neighborhood Socioeconomic Deprivation is Associated with Worse Cognitive Performance and in vivo Amyloid Accumulation

38/100 ✓ Peer-reviewed Risk factors NPJ dementia

Key finding: Socioeconomic disadvantage (SED) has been associated with poorer brain health, yet its underlying pathology remains incompletely understood. +4 more findings

• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Implications of virus-induced stress granules in tauopathies

31/100 ✓ Peer-reviewed Disease mechanisms Translational Neurodegeneration

Key finding: Tauopathies are characterized by aberrant tau structure and function, which is associated with neurodegenerative dementias, such as Alzheimer's disease, Pick's disease, and frontotemporal dementia, as well as the motor neuron disease amyotrophic lateral sclerosis.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Comparison of quality of sepsis care among patients with vs. without acute mental health crises

16/100 ⚠ Preprint — not yet peer-reviewed Clinical safety medRxiv

Key finding: Previous research has shown patients with mental health issues receive worse quality of diabetes and cardiac care and have poorer outcomes compared with those without mental health issues. +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Integrative Multimodal Subtyping, Risk of Incident Mild Cognitive Impairment, and Differential Cardiometabolic Treatment Effects: A Prospective Cohort Study in the All of Us Research Program

16/100 ⚠ Preprint — not yet peer-reviewed Drug development medRxiv

Key finding: Four distinct subtypes were identified: I low-risk healthy aging, II behavioral/social vulnerability, III cardiometabolic–depressive multimorbidity, and IV mixed social-medical vulnerability profiles. +4 more findings

• Treatments
• Early Stage

Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice

16/100 ⚠ Preprint — not yet peer-reviewed Treatments bioRxiv

Key finding: Across 82 mice, APOE4 mice showed stepwise reductions in the number of plaques from one to ten days, with significant reductions in the subiculum (48%) and thalamus (40%) at ten days. +4 more findings

• Brain Biology
• Side Effects

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function

45/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: Transcriptomic profiling revealed upregulation of ALP and downregulation of inflammatory signalling. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Associations of Lifetime Cognitive Enrichment With Incident Alzheimer Disease Dementia, Cognitive Aging, and Cognitive Resilience

50/100 ✓ Peer-reviewed Brain tissue and pathology Neurology

Key finding: Lifetime exposure to cognitive enrichment was related to lower risk of AD dementia and a slower rate of cognitive decline, including after adjustment for common ADRD pathologies, indicating higher resilience provided by lifetime enrichment. +1 more finding

Full summary, score breakdown and related studies → Original source

A dual-pathway model of depression's mediation between chronic pain and dementia

49/100 ✓ Peer-reviewed Cognitive tests and assessment Experimental Gerontology

Key finding: After adjusting for potential confounders, multivariable logistic regression models revealed that the prevalence of dementia was significantly higher in individuals with chronic pain than in those without. +2 more findings

Full summary, score breakdown and related studies → Original source

Digital biomarkers for early agitation detection in dementia: a scoping review of emerging wearable and smart technologies for personalized care

56/100 ✓ Peer-reviewed Digital health tools Frontiers in Neurology

Key finding: The reviewed studies demonstrated that wearable sensors, particularly those employing multimodal data and personalized machine learning models, enable reliable detection of agitation symptoms and support timely, tailored interventions. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Alzheimer Disease and the Utility of PET

32/100 ✓ Peer-reviewed Treatments Journal of Nuclear Medicine Technology

Key finding: AD presents with symptoms of cognitive impairment that worsen with disease progression, ultimately affecting an individual's functional abilities, independence, and overall health.

• Treatments
• Brain Scans

Full summary, score breakdown and related studies → Original source

Quantitative Amyloid Brain Imaging: A Literature Review of the Centiloid Scale in Alzheimer Disease Evaluation

47/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine Technology

Key finding: The Centiloid method demonstrates strong intertracer and interscanner harmonization when standardized to the 11C-Pittsburgh compound B reference, with high correlation (r2 > 0.9) across 18F-labeled tracers, including florbetapir, flutemetamol, and florbetaben. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

PET Imaging in Alzheimer Disease in the Era of Antiamyloid Therapy in the United States: Clinical Utility, Quantification, and Policy Landscape

43/100 ✓ Peer-reviewed Biomarkers Journal of Nuclear Medicine Technology

Key finding: Amyloid PET enables improved detection of amyloid-β plaques within the brain. +4 more findings

• Treatments
• Brain Scans
• Policy

Full summary, score breakdown and related studies → Original source