Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 16,701–16,725 of 27,380 studies, newest first · page 669 of 1096.
September 2015 20
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2015-09-02
Combining billing codes, clinical notes, and medications from electronic health records provides superior phenotyping performance
45/100 ✓ Peer-reviewed Digital health tools Journal of the American Medical Informatics Association : JAMIA
Key finding: Multiple EHR components provide a more consistent and higher performance than a single one for the selected phenotypes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-02
Type 2 diabetes mellitus and biomarkers of neurodegeneration
61/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: T2DM may promote neurodegeneration independent of AD dementia diagnosis, and its effect may be driven by tau phosphorylation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study
71/100 ✓ Peer-reviewed Clinical safety BMJ
Key finding: 21% (7065) of the cohort had a record of mental illness at study entry, 25% (8300) had a record of challenging behaviour, and 49% (16,242) had a record of prescription of psychotropic drugs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study
64/100 ✓ Peer-reviewed Drug development Annals of internal medicine
Key finding: Ankylosing spondylitis is associated with increased risk for vascular mortality. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people
40/100 ✓ Peer-reviewed Cognitive tests and assessment Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Key finding: An example of a novel form of cognitive enhancement using the technological advancement of a game on an iPad that also acts to increase motivation is presented. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Dietary Patterns and Cognitive Decline Among Chinese Older Adults
62/100 ✓ Peer-reviewed Prevention trials Epidemiology (Cambridge, Mass.)
Key finding: Our findings suggest that an adapted Mediterranean diet or a wheat-based, diverse diet with similar components may reduce the rate of cognitive decline in later life in the Chinese population. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis
36/100 ✓ Peer-reviewed Disease mechanisms Neuron
Key finding: Our findings reveal a novel role for appoptosin in neurological disorders with tau neuropathology, linking caspase-3-mediated tau cleavage to synaptic dysfunction and behavioral/motor defects.
Full summary, score breakdown and related studies → Original source
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2015-09-01
Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis
55/100 ✓ Peer-reviewed TREM2 and immune genetics American journal of Alzheimer's disease and other dementias
Key finding: Twelve studies were considered for analysis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Back to the future – feasibility of recruitment and retention to patient education and telephone follow-up after hip fracture: a pilot randomized controlled trial
56/100 ✓ Peer-reviewed Health systems and care delivery Patient Preference and Adherence
Key finding: Our pilot study results indicate that it is feasible to recruit, retain, and provide follow-up telephone coaching to older adults after hip fracture. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease
63/100 ✓ Peer-reviewed Brain tissue and pathology JAMA neurology
Key finding: Patients with AD and individuals at risk for AD show reduced glucose metabolism, as indexed by fludeoxyglucose F 18-labeled positron emission tomography (FDG-PET). +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Magnetic resonance imaging biomarkers for the early diagnosis of Alzheimer's disease: a machine learning approach
50/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in neuroscience
Key finding: Magnetic Resonance (MR)-related biomarkers have been recently identified by the use of machine learning methods for the in vivo differential diagnosis of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Marked gender differences in progression of mild cognitive impairment over 8 years
60/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia (New York, N. Y.)
Key finding: Women with MCI have greater longitudinal rates of cognitive and functional progression than men. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-09-01
Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies
52/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD
Key finding: Research increasingly suggests that subjective cognitive decline (SCD) in older adults, in the absence of objective cognitive dysfunction or depression, may be a harbinger of non-normative cognitive decline and eventual progression to dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
59/100 ✓ Peer-reviewed Lewy body dementia Nature neuroscience
Key finding: C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
56/100 ✓ Peer-reviewed Lewy body dementia Cell
Key finding: We suggest that LCD-mediated LLPS contributes to the assembly of stress granules and their liquid properties and provides a mechanistic link between persistent stress granules and fibrillar protein pathology in disease.
Full summary, score breakdown and related studies → Original source
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2015-09-01
Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis
70/100 ✓ Peer-reviewed Getting a diagnosis JAMA internal medicine
Key finding: Besides the MMSE, there are many other tests with comparable diagnostic performance for detecting dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation
40/100 ✓ Peer-reviewed Prevention and risk Cold Spring Harbor perspectives in biology
Key finding: Exposure to stress is one of the best-known negative regulators of adult neurogenesis (AN). +4 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial
75/100 ✓ Peer-reviewed Treatments JAMA
Key finding: With the sequential parallel comparison design, 152 patients received dextromethorphan-quinidine and 127 received placebo during the study. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
58/100 ✓ Peer-reviewed Genetics Oncotarget
Key finding: The impact of APOE4 on brain metabolism and structure is modified by sex. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-09-01
Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age
66/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Within-person changes in CSF biomarkers were also compared with changes in cortical PiB binding and progression to a CDR higher than 0 at follow-up. +1 more finding
Full summary, score breakdown and related studies → Original source
August 2015 5
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2015-08-31
Neural Plastic Effects of Cognitive Training on Aging Brain
72/100 ✓ Peer-reviewed Prevention trials Neural plasticity
Key finding: Increasing research has evidenced that our brain retains a capacity to change in response to experience until late adulthood. +2 more findings
Full summary, score breakdown and related studies → Original source
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2015-08-31
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
59/100 ✓ Peer-reviewed Risk genes beyond APOE Nature
Key finding: Two principal physiological pathways either prevent or promote amyloid-β generation from its precursor, β-amyloid precursor protein (APP), in a competitive manner. +3 more findings
Full summary, score breakdown and related studies → Original source
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2015-08-31
Dynamic reconfiguration of frontal brain networks during executive cognition in humans
53/100 ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America
Key finding: This reconfiguration, which characterizes "network flexibility," employs transient and heterogeneous connectivity between frontal systems, which we refer to as "integration." +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-08-28
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies
36/100 ✓ Peer-reviewed Digital health tools Ageing research reviews
Key finding: Such cognitive changes are associated with different structural and functional alterations in the human neural network that underpins episodic memory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2015-08-28
Cognitive Function in Individuals With Physical Frailty but Without Dementia or Cognitive Complaints: Results From the I-Lan Longitudinal Aging Study
52/100 ✓ Peer-reviewed Digital health tools Journal of the American Medical Directors Association
Key finding: Even without subjective cognitive complaints, higher risk of cognitive impairment is presented in the prefrail and frail individuals. +4 more findings
Full summary, score breakdown and related studies → Original source
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