Newest studies

Milestone Review: The History of Molecular Genetics Analysis of Alzheimer's Disease

44/100 ✓ Peer-reviewed Genetics Journal of Neurochemistry

Key finding: Alzheimer research has been driven by genetic findings: from the 1990s until about 2005, by the identification of amyloid precursor protein (APP) and presenilin (PSEN) mutations, leading to the formulation of the amyloid hypothesis, and then from ~2007 by genome-wide studies which have led to the increasing appreciation of the importance of microglial insufficiency in the disease pathogenesis. +2 more findings

• Genetics

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Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics

50/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia Translational Research & Clinical Interventions

Key finding: The characteristics of the cohort revealed significant groupwise differences in age, education, sex, and cognitive diagnosis. +4 more findings

• Health Equity
• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

Structural and social determinants of dementia risk among adults racialized as Black: Results from a community‐based system dynamics approach

49/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: CBSD revealed a framework for how economic hardship, especially low income and unemployment, reduces access to physical and mental healthcare, driving dementia risk. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Participation in clinical research among racial and ethnic minority Medicare beneficiaries: Evidence from the IDEAS study

34/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia

Key finding: We identified 11,480 beneficiaries in the IDEAS study sample and 3,008,067 in the eligible sample. +4 more findings

• Health Equity
• Policy

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Top 20 Research Studies of 2024 for Primary Care Physicians

63/100 ✓ Peer-reviewed Drug development American family physician

Key finding: Based on a network meta-analysis, the oral antibiotics most likely to be effective for community-acquired pneumonia are telithromycin (not available in the United States), azithromycin, amoxicillin-clavulanate, and the quinolones levofloxacin and nemonoxacin (not available in the United States). +3 more findings

• Care Services

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Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study

49/100 ✓ Peer-reviewed Tau biomarkers The Journal of frailty & aging

Key finding: Intrinsic capacity (IC) is a recent key concept proposed by the World Health Organization (WHO) based on aspects of functional ability (both physical and mental) rather than the presence or absence of diseases, with a potential to predict several health outcomes. +3 more findings

• Biomarkers

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Cerebrospinal Fluid Amyloid and Tau Biomarker Changes Across the Alzheimer Disease Clinical Spectrum

64/100 ✓ Peer-reviewed Tau biomarkers JAMA network open

Key finding: The trajectories of core Alzheimer disease (AD) cerebrospinal fluid (CSF) biomarkers and the concurrent cognitive changes across the clinical spectrum remain unclear yet are important for clinical trial design. +3 more findings

• Biomarkers

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Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease

55/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature communications

Key finding: Although many proteomic alterations were shared across DS, LOAD, and ADAD, DS demonstrated more severe changes in immune-related proteins, extracellular matrix pathways, and plasma proteins likely related to blood-brain barrier dysfunction compared to LOAD. +2 more findings

• Down Syndrome
• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome

56/100 ✓ Peer-reviewed Digital health tools Nature communications

Key finding: Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyond the dynamic range of liquid chromatography-mass spectrometry of unfractionated plasma. +4 more findings

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ACE trial design: Equol targeting estrogen receptor-β in vascular and cognitive aging

62/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: In preclinical studies, it has demonstrated vascular protective and antioxidant effects, with emerging evidence suggesting potential neuroprotective properties. +1 more finding

• Clinical Trials

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Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease

68/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: There were 838 BioFINDER-2 participants (mean age, 73.9 [SD, 7.3] years; 431 women [51%]; 407 men [49%]) and 380 ADNI participants (average age, 72.9 [SD, 7.0] years; 194 women [51%]; 186 mean [49%]) included. +2 more findings

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Contribution of Modifiable Midlife and Late-Life Vascular Risk Factors to Incident Dementia

69/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: A total of 7731 participants were included in analysis of risk factors measured at age 45 to 54 years (4494 female [58%]; 2207 Black [29%]; 5524 White [71%]), 12 274 contributed to analysis of risk factors measured at age 55 to 64 years (6698 female [55%]; 2886 Black [24%]; 9388 White [76%]), and 6787 contributed to analysis of risk factors measured at age 65 to 74 years (3764 female [56%], 1375 Black [20%]; 5412 White [80%]). +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Lecanemab Treatment in a Specialty Memory Clinic

71/100 ✓ Peer-reviewed Treatments JAMA Neurology

Key finding: The most significant adverse events associated with these therapies are infusion-related reactions and amyloid-related imaging abnormalities (ARIA) with edema/effusion (ARIA-E) and/or hemorrhage/hemosiderin deposition (ARIA-H). +4 more findings

• Treatments
• Side Effects

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Comparison of plasma ALZpath p-Tau217 with Lilly p-Tau217 and p-Tau181 in a neuropathological cohort

54/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica communications

Key finding: Plasma biomarkers were compared with densities of post-mortem-assessed amyloid plaques and neurofibrillary changes. +4 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Oxidative stress – Alzheimer’s disease – DNA methylation: the role of arsenic

36/100 ✓ Peer-reviewed Disease mechanisms Essays in Biochemistry

Key finding: The etiology of AD is multifactorial, suggesting that, in addition to a genetic component, the environment may strongly influence its onset and progression. +2 more findings

• Brain Biology

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Alzheimer’s disease polygenic risk’s association with all-cause dementia through the plasma metabolome in the UK Biobank study

51/100 ✓ Peer-reviewed Long-term cohort studies GeroScience

Key finding: Higher AD PRS was associated with increased risks of all-cause dementia (HR: 1.75, 95% CI: 1.70-1.79, P < 0.001) and AD (HR: 2.02, 95% CI: 1.95-2.09, P < 0.001), with stronger effects in women for both outcomes when considering the main AD PRS which was related to APOE4 status. +3 more findings

• Genetics

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EEG SIGNAL ANALYSIS FOR CLASSIFYING ALZHEIMER’S AND FRONTOTEMPORAL DEMENTIA DISORDERS USING ENSEMBLE METHODS

41/100 ✓ Peer-reviewed Lewy body dementia International Journal of Advances in Signal and Image Sciences

Key finding: Accurate identification of neurodegenerative disorders, including Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD), is crucial for prompt medical intervention.

• Other Dementias

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ARTS is associated with vascular risk factors, MCI, dementia, and stroke

49/100 ✓ Peer-reviewed Disparities Alzheimer s & Dementia

Key finding: Higher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. +4 more findings

• Risk Factors
• Health Equity
• Early Stage

Full summary, score breakdown and related studies → Original source

Ambroxol as a Treatment for Parkinson Disease Dementia: A Randomized Clinical Trial

58/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: Mean (SD) β-glucocerebrosidase levels were higher at week 26 (ambroxol, 12.45 [1.97] nmol/h/mg; 91% CI, 11.54-13.36 nmol/h/mg); placebo, 8.50 [1.96] nmol/h/mg; 91% CI, 7.65-9.34 nmol/h/mg; P = .05) in the ambroxol group compared with placebo. +2 more findings

• Clinical Trials
• Treatments

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Cognition-Eye-Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging

50/100 ✓ Peer-reviewed Brain scans and imaging Journal of magnetic resonance imaging : JMRI

Key finding: Reductions of FALFF in temporal regions, especially the left superior temporal gyrus (STG) in MCI patients, were linked to decreased RNFL thickness and increased FAZ area significantly. +4 more findings

• Brain Scans

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The Association Between Possible Sarcopenia and Delirium Onset in Older Patients With Acute Stroke

51/100 ✓ Peer-reviewed Clinical safety Cureus

Key finding: Our findings suggest that possible sarcopenia is a significant and independent predictor of delirium in older patients with acute stroke. +4 more findings

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Cerebral Amyloid Angiopathy With Progressive Cortical Superficial Siderosis and Convexity Subarachnoid Hemorrhage in an Apolipoprotein E (APOE) ε2/ε2 Homozygous Patient: A Case Report and Literature Review

31/100 ✓ Peer-reviewed Brain tissue and pathology Cureus

Key finding: It is associated with intracerebral hemorrhage (ICH), cognitive decline, and gait disturbance. +3 more findings

• Genetics

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Population Attributable Fraction of Modifiable Risk Factors for Dementia in Turkey

46/100 ✓ Peer-reviewed Risk factors Dementia

Key finding: Dementia affects approximately 55 million people globally, with modifiable risk factors contributing significantly to its prevalence. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

The pTau217/Aβ1-42 plasma ratio: The first FDA-cleared blood biomarker test for diagnosis of Alzheimer's disease

46/100 ✓ Peer-reviewed Biomarkers Drug discoveries & therapeutics

Key finding: In clinical validation, concordance rates with amyloid PET brain scans/the results of cerebrospinal fluid biomarker detection were 91.7% (positive) and 97.3% (negative).

• Biomarkers
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Recent Advances in Antibody Therapy for Alzheimer's Disease: Focus on Bispecific Antibodies

45/100 ✓ Peer-reviewed Treatments International journal of molecular sciences

Key finding: The combination of rationally designed bispecific antibodies with fluid and imaging biomarkers could show potential for overcoming existing therapeutic challenges and delivering significant clinical advantages.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source