Newest studies

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

45/100 ✓ Peer-reviewed Lewy body dementia Molecular Psychiatry

Key finding: Additionally, we found that secretory factors from MAPT IVS10 + 16 iMGLs impact neuronal health, reducing synaptic density in neurons. +1 more finding

• Brain Biology
• Other Dementias

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Lipoprotein(a) and risk of dementia: findings from three cohort studies

45/100 ✓ Peer-reviewed How common it is European Heart Journal

Key finding: On continuous scales, lipoprotein(a) levels were not associated with the risk of Alzheimer's disease or vascular-related dementia. +4 more findings

• Risk Factors

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Plant-Based Diet and Risk of Iron-deficiency Anemia. A Review of the Current Evidence and Implications for Preventive Strategies

40/100 ✓ Peer-reviewed Prevention and risk Current Nutrition Reports

Key finding: Non-heme iron, which is more abundant in plant-based sources, poses challenges about its lower bioavailability and this could contribute to an increased risk of anemia in these populations. +1 more finding

• Lifestyle

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Multidomain interventions for prevention of dementia: Achievements, challenges and future perspectives

40/100 ✓ Peer-reviewed Prevention and risk Geriatrics and gerontology international/Geriatrics & gerontology international

Key finding: The other three trials failed to show significant cognitive improvement, partly due to the devastating impact of the coronavirus disease 2019 pandemic. +1 more finding

• Prevention
• Risk Factors
• Policy

Full summary, score breakdown and related studies → Original source

Terapias emergentes para la enfermedad de Alzheimer: revisión sistemática de anticuerpos anti-amiloide y mecanismos alternativos

29/100 ✓ Peer-reviewed Treatments Revista Científica de Salud y Desarrollo Humano

Key finding: Resultados: Se identificaron 34 estudios relevantes. +4 more findings

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Herpes Zoster Vaccination and Dementia Occurrence (Australian natural experiment)

78/100 ✓ Peer-reviewed Prevention and risk JAMA

Key finding: In this sample of 101 219 patients, 52.7% were women and mean age was 62.6 years (SD, 9.3 years) as of November 1, 2016. +1 more finding

• Prevention
• Care Services

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Autophagy and Alzheimer's Disease: Mechanisms and Impact Beyond the Brain

43/100 ✓ Peer-reviewed Disease mechanisms Cells

Key finding: However, impaired autophagy contributes significantly to AD pathogenesis by disrupting proteostasis, exacerbating neuroinflammation, and promoting synaptic dysfunction.

• Brain Biology

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Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2

43/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Alzheimer's disease : JAD

Key finding: Circular RNAs (circRNAs) are emerging as a promising object of study in Alzheimer's disease (AD) pathogenesis. +3 more findings

• Genetics

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CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process

59/100 ✓ Peer-reviewed Prevention trials Frontiers in Aging Neuroscience

Key finding: The CITA GO-ON Study, as a part of the World-Wide FINGERS network, is designed to validate the efficacy of a multidomain lifestyle intervention for dementia prevention and contribute valuable data to inform public health strategies fostering healthy, active aging. +2 more findings

• Clinical Trials
• Prevention
• Lifestyle

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Effects of Experimental Periodontitis and Periodontal Treatment on Alzheimer‐Like Pathology in Rats

36/100 ✓ Peer-reviewed Inflammation and the immune system Oral Diseases

Key finding: Rats in the AD and AD + P groups performed worse in behavioral tests compared to controls (p 0.05). +4 more findings

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The increase in TDP-43 and neurogranin blood levels at different stages of cognitive impairment in the elderly people: A cross-sectional study

39/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Alzheimer s Disease

Key finding: Aβ 42 , TDP-43, and neurogranin show potential as blood-based biomarkers for cognitive decline and may provide insight into the pathogenesis of neurodegeneration. +2 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies

44/100 ✓ Peer-reviewed Lewy body dementia Annals of Neurology

Key finding: Surprisingly, levels of strain A and B aSyn species were higher in plasma from individuals with PD compared to DLB in 2 independent cohorts. +4 more findings

• Other Dementias

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Employment Status, Decision-Making, and Sleep Among Hispanic and Latinx Dementia Family Caregivers: A Secondary Data Analysis

32/100 ✓ Peer-reviewed Disparities Western Journal of Nursing Research

Key finding: Participants had a mean age of 55.1 years (SD = 14), were predominantly female, and primarily cared for a parent. +4 more findings

• Health Equity
• Caregiving
• Lifestyle

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Sleep at home for older persons with dementia and their caregivers: a qualitative study of their experiences and challenges

42/100 ✓ Peer-reviewed Caregiving European Journal of Ageing

Key finding: The results provide insight into the experiences of IC at home regarding their sleep and the sleep of PwD at home. +1 more finding

• Caregiving
• Lifestyle

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Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

76/100 ✓ Peer-reviewed Brain scans and imaging JAMA

Key finding: Among the 6514 participants (mean age, 69.5 years; 50.5% female), median follow-up time ranged from 1.5 to 4.0 years. +4 more findings

• Brain Scans
• Early Stage

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Clinical Management of Cerebral Amyloid Angiopathy

42/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Clinical Medicine

Key finding: The vast majority of CAA remains sporadic, with increasing prevalence with age and very frequent coexistence with Alzheimer’s disease. +4 more findings

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A single dose of a vectorized mAb targeting TDP-43 potently inhibits the neuropathology in a model of ALS/FTD

36/100 ✓ Peer-reviewed Brain tissue and pathology Molecular Therapy

Key finding: A single intracisternal administration of vmAb ACI-5891 demonstrated a broad brain distribution and sustained expression (i.e., months) in the serum, cerebrospinal fluid, and brain of mice.

• Brain Biology

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Safety, Cognitive, and Behavioral Outcomes in Patients with Dementia with Lewy Bodies Treated with Nilotinib

48/100 ✓ Peer-reviewed Lewy body dementia Journal of Clinical Medicine

Key finding: Of 43 individuals enrolled, 14 were women (33%); age (mean ± SD) was 73 ± 8.5 years. +4 more findings

• Other Dementias
• Clinical Trials
• Side Effects

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Enhancing Delirium Prediction and Prevention in Elderly Patients Through Machine Learning-Based Analysis

47/100 ✓ Peer-reviewed Clinical safety Sultan Qaboos University medical journal

Key finding: A total of 327 patients were included in this study. +4 more findings

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To reveal and acknowledge an iatrogenic cerebral amyloid angiopathy: a vascular neurologist and neurosurgeon collaborative perspective

36/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in Neurology

Key finding: It is often associated with recurrent ICH, seizures, and cognitive impairment. +4 more findings

• Brain Biology

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Integrative and interpretable framework to unveil the neurophysiological fingerprint of Alzheimer’s disease and mild cognitive impairment: A machine learning-SHAP approach

38/100 ✓ Peer-reviewed Digital health tools Journal of Applied Biomedicine

Key finding: Dementia and mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) are neurological pathologies associated with disruptions in brain electromagnetic activity, typically studied using magnetoencephalography (MEG) and electroencephalography (EEG). +2 more findings

• Digital Tools
• Early Stage

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Bridging the Gap: Missing Data Imputation Methods and Their Effect on Dementia Classification Performance

40/100 ✓ Peer-reviewed Digital health tools Brain Sciences

Key finding: On the test set, MICE imputation yielded the highest accuracy for both RF (0.76) and LR (0.81), while SVM performed best with median imputation (0.81). +4 more findings

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Potential Role of Lymphovenous Bypass in Mitigating Alzheimer's Disease Dementia

39/100 ✓ Peer-reviewed Getting a diagnosis Archives of Plastic Surgery

Key finding: This case report explores the therapeutic potential of lymphovenous bypass (LVB) surgery performed at the neck in neurodegenerative diseases, specifically Alzheimer's disease (AD) dementia. +1 more finding

• Diagnosis

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Protective exercise responses in the dentate gyrus of Alzheimer's disease mouse model revealed with single-nucleus RNA-sequencing

46/100 ✓ Peer-reviewed Genetics Nature neuroscience

Key finding: We identified a neurovascular-associated astrocyte subpopulation, the abundance of which was reduced in AD, whereas its gene expression signature was induced with exercise. +4 more findings

• Brain Biology
• Prevention
• Lifestyle

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Graph Spectral Analysis Using Electroencephalography in Alzheimer Disease and Frontotemporal Dementia Patients

35/100 ✓ Peer-reviewed Lewy body dementia International Journal of Neural Systems

Key finding: These two sort of measures were then utilized in a binary AD/controls classification problem to test their utility in AD diagnosis and identify most valuable parameters. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source