Newest studies

7 FDA Approved CSF Biomarkers Demonstrate Strong Predictive Value for Identification of Alzheimer Disease Based on PET Scan in Patients with Standalone Alzheimer Cognitive Screening Tests

34/100 ✓ Peer-reviewed Tau biomarkers American Journal of Clinical Pathology

Key finding: CSF pTau181/Ab42 ratio is a diagnostic marker for Alzheimer disease correlated well with PET scan compared to various standalone cognitive screening assessment. +4 more findings

• Biomarkers
• Diagnosis
• Treatments

Full summary, score breakdown and related studies → Original source

HIF‐1 Targeting Intervention Renders Protection From Alzheimer's‐Like Pathology in a Humanized Mice Model of HIV Infection

37/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Extracellular Vesicles

Key finding: Intranasally administered mCherry-TSG101-tagged ADEVs in mice demonstrated efficacy of brain delivery, especially to the hippocampus and cortex. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Detecting Mild Cognitive Impairment to Alzheimer’s Disease Progression by fMRI Using Convolutional Neural Network and Long-short Term Memory

34/100 ✓ Peer-reviewed Mild cognitive impairment Basic and Clinical Neuroscience Journal

Key finding: The results showed that the best validation scores were achieved by the CNN-LSTM model after integrating clinical attributes, with an accuracy of 92.47%. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology

47/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer s & Dementia

Key finding: SSRI treatment showed no significant effect on AD dementia progression (hazard ratio = 1.64, 95% confidence interval: 0.61 to 4.38) or cognitive trajectories, regardless of AD pathology. +4 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Pathomechanisms, genetic insights, and therapeutics in diabetes-associated dementia

36/100 ✓ Peer-reviewed Risk factors Journal of Endocrinology

Key finding: Type 2 diabetes (T2DM) significantly increases the risk of dementia due to overlapping metabolic, molecular, and genetic factors.

• Risk Factors
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Perspectives on artificial intelligence-enabled socially assistive robots in long-term care: Experiences with LOVOT among people with dementia and family caregivers

36/100 ✓ Peer-reviewed Digital health tools Digital Health

Key finding: Three themes identified include (a) LOVOT's role in supporting engagement and stimulating conversation, (b) the irreplaceability of human touch and emotional nuances, and (c) concerns about ownership and equitable resource allocation. +3 more findings

• Digital Tools
• Caregiving

Full summary, score breakdown and related studies → Original source

Real‐world prediction of early‐onset dementia by health record data: A multi‐center machine learning study

36/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

Key finding: The CatBoost-based risk model achieved an area under the receiver-operating characteristic curve (AUROC) of 0.814 (<70 years) and 0.892 (<65 years). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Cumulative and variable depression symptom exposure and incident dementia: Panel data analysis of four longitudinal cohort studies

56/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia

Key finding: Each 1-unit increase in cumulative score was associated with a 3%-8% higher dementia hazard across cohorts. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Development of a Rural and Remote Dementia Training Framework

34/100 ✓ Peer-reviewed Disparities Australian Journal of Rural Health

Key finding: Synthesis of the results identified three overarching key principles and seven actionable practices for consideration when designing or delivering dementia education to the rural and remote health and aged care workforce. +1 more finding

• Health Equity
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Minority Stress, Discrimination, and Health Outcomes Among LGBTQ+ Older Adult Dementia Caregivers

42/100 ✓ Peer-reviewed Disparities American Journal of Alzheimer s Disease & Other Dementias®

Key finding: Interaction effects suggest that minority stress may exacerbate mental health problems among MCI/ADRD caregivers.

• Health Equity
• Caregiving

Full summary, score breakdown and related studies → Original source

Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias

46/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer s & Dementia

Key finding: Our findings suggest that disease progression follows a stage-dependent MVD pattern that can identify at-risk regions. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Process evaluation of APPLE-Tree (active prevention in people at risk of dementia through lifestyle behaviour change and technology to build resilience): dementia prevention study focused on health and lifestyle changes

60/100 ✓ Peer-reviewed Prevention and risk BJPsych Open

Key finding: A total of 346 of 374 (92.5%) intervention arm participants received some intervention (reach), and 305 of 374 (81.6%) attended ≥5 main sessions (predefined as adhering: dose). +4 more findings

• Prevention
• Clinical Trials

Full summary, score breakdown and related studies → Original source

A Causal Association Between Drug Use and Cognitive Impairment: A Two‐Sample Mendelian Randomization Study

34/100 ✓ Peer-reviewed Genetics Brain and Behavior

Key finding: The IVW analysis indicated that antithrombotic agents (odds ratio [OR] = 2.12, 95% confidence interval [CI] = 1.03-4.34, p = 0.04), HMG CoA reductase inhibitors (OR = 1.36, 95% CI = 1.07-1.72, p = 0.01), and salicylic acid and derivatives (OR = 2.77, 95% CI = 1.44-5.32, p = 0.002) are a strong risk factor for dementia with Lewy bodies (DLB); diuretics (OR = 1.13, 95% CI = 1-1.27, p = 0.047) and calcium channel blockers (OR = 1.16, 95% CI = 1.04-1.29, p = 0.007) might be a risk factor for vascular dementia; thyroid preparations (OR = 1.03, 95% CI = 1.01-1.06, p = 0.01), diuretics (OR = 1.06, 95% CI = 1.02-1.11, p = 0.004), and immunosuppressants (OR = 1.07, 95% CI = 1.01-1.12, p = 0.001), are a risk factor for frontotemporal dementia; HMG CoA reductase inhibitors is a risk factor for dementia in Alzheimer disease (OR = 1.32, 95% CI = 1.05-1.65, p = 0.01). +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

T cell drives microglia specific metabolic plasticity and neurodegeneration in Alzheimer disease 4098

31/100 ✓ Peer-reviewed Genetics The Journal of Immunology

Key finding: Of note, using large-scale transcriptome and chromatin profiling, we show that T cell shape microglia-specific metabolic plasticity in both genetic and epigenetic resolution. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B

68/100 ✓ Peer-reviewed Genetics Alzheimer s & Dementia

Key finding: Two regions achieved genome-wide significance with TDP-43: apolipoprotein E (APOE) and TMEM106B. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias

39/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: We highlight a general overview and methodology of TNS. +4 more findings

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Quantifying diagnostic signal decay in dementia: a national study of Medicare hospitalization data

59/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia

Key finding: Alzheimer's and vascular dementia codes showed high regional variability. +4 more findings

• Policy
• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Clinician-Identified Health Characteristics and Palliative Care Eligibility: Is Dementia Overlooked?

36/100 ✓ Peer-reviewed Health systems and care delivery The American Journal of Managed Care

Key finding: Of 343 palliative care evaluations (for 322 unique patients), 38% were of patients who identified as African American/Black, 38% as White, 9% as Asian/Pacific Islander, and 15% as other races; 41% were of patients who identified as Hispanic/Latino (measured separately from race); 80% were of female patients; and the mean patient age was 88 years. +4 more findings

• End-of-Life Care
• Health Equity

Full summary, score breakdown and related studies → Original source

Neuropathological changes and amyloid-related imaging abnormalities in Alzheimer's disease treated with aducanumab versus untreated: a retrospective case-control study

67/100 ✓ Peer-reviewed Drug development The Lancet. Neurology

Key finding: Understanding the neuropathological effects of amyloid β (Aβ)-targeting therapies and amyloid-related imaging abnormalities (ARIA) in Alzheimer's disease is critical for optimising treatment efficacy and patient outcomes. +3 more findings

• Treatments
• Side Effects
• Brain Scans

Full summary, score breakdown and related studies → Original source

A 3-Week Ketogenic Diet Increases Global Cerebral Blood Flow and Brain-Derived Neurotrophic Factor

57/100 ✓ Peer-reviewed Treatments The Journal of clinical endocrinology and metabolism

Key finding: The beneficial effects of a ketogenic diet (KD) on neurodegenerative conditions such as mild cognitive impairment (MCI) and Alzheimer disease (AD) are increasingly acknowledged, with potential implications for the general population as well. +1 more finding

• Brain Scans
• Lifestyle

Full summary, score breakdown and related studies → Original source

Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study

58/100 ✓ Peer-reviewed Biomarkers Alzheimer's & Dementia

Key finding: Plasma GFAP is a prognostic biomarker in CU older adults, predicting cognitive and biological changes, with stronger associations observed in females, highlighting a possible sex-specific vulnerability. +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease

72/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: Participants had a mean (SD) age of 66.9 (9.9) years; 971 (33.3%) were Aβ positive by either CSF or PET, 1667 (57.2%) were women, and 1108 (38.1%) carried at least 1 APOE ε4 allele. +4 more findings

• Biomarkers
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Incidence and Prevalence of Frontotemporal Dementia: A Systematic Review and Meta-Analysis

67/100 ✓ Peer-reviewed How common it is JAMA Neurology

Key finding: In this systematic review and meta-analysis, estimates indicate that FTD is comparable in frequency to dementia with Lewy bodies and occurs at higher rates than progressive supranuclear palsy, corticobasal syndrome, and amyotrophic lateral sclerosis. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

GUIDE and Beyond: Strategies for Comprehensive Dementia Care Integration

42/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: Proposes a four-step implementation strategy: identify leaders/community partners, build a tailored value proposition with data, execute start-up with an integrated care team, and plan for long-term sustainability +2 more findings

Full summary, score breakdown and related studies → Original source

PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv : the preprint server for biology

Key finding: Importantly, we observed vascular amyloid-β deposition in wild-type mice without genetic Alzheimer's disease mutations, suggesting that metabolic stress contributes to cerebrovascular amyloid pathology. +1 more finding

• Brain Biology
• Other Dementias
• Lifestyle

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source