Newest studies

Aducanumab: A look two years after its approval

43/100 ✓ Peer-reviewed Treatments Biomedica : revista del Instituto Nacional de Salud

Key finding: Alzheimer’s disease is the leading cause of dementia worldwide and a critical public health problem. +4 more findings

• Treatments

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Incidence of Traumatic Brain Injury in a Longitudinal Cohort of Older Adults

57/100 ✓ Peer-reviewed Risk factors JAMA Network Open

Key finding: Among 9239 eligible respondents, 5258 (57.7%) were female and 1210 (9.1%) were Black, 574 (4.7%) were Hispanic, and 7297 (84.4%) were White. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

[Blood biomarkers open a window to brain pathophysiology in Alzheimer's disease]

34/100 ✓ Peer-reviewed Tau biomarkers Lakartidningen

Key finding: Plasma levels of amyloid β, specifically the Aβ42/40 ratio, are reduced in Alzheimer's disease (AD) and show concordance with brain amyloidosis assessed by PET, but the overlap with normal elderly may be too large for reliable use in clinical applications. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Affiliate Stigma among family caregivers of individuals with dementia in China: a cross-sectional study

59/100 ✓ Peer-reviewed Caregiving Frontiers in public health

Key finding: The mean score for affiliate stigma of dementia family caregivers was 48.09 ± 16.38 (range: 22-86). +3 more findings

• Caregiving

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Causal association between particulate matter 2.5 and Alzheimer's disease: a Mendelian randomization study

43/100 ✓ Peer-reviewed Risk factors Frontiers in public health

Key finding: Our MR analysis identified a notable association between genetically predicted PM2.5 (PM with a diameter of 2.5 μm or less) exposure and an elevated risk of AD (odds ratio, 2.160; 95% confidence interval, 1.481 to 3.149; p < 0.001). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-ADmini randomized controlled trial

82/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

Key finding: Primary outcome was feasibility of the multimodal intervention, evaluated by recruitment rate during a 6-month recruitment phase, overall adherence in each intervention arm, and 6-month retention rate. +4 more findings

• Clinical Trials
• Lifestyle

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Medicare Advantage enrollment and outcomes of post-acute nursing home care among patients with dementia

36/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs Scholar

Key finding: After adjusting for patient-level characteristics and county fixed effects, we found that MA enrollment was not associated with days spent at home, nursing home days, likelihood of becoming a long-stay resident, hospital days, hospital readmission, or 1-year mortality. +3 more findings

• Care Services
• Policy

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Geographic Variation of Antidementia and Antipsychotic Medication Use Among US Nursing Home Residents With Dementia

49/100 ✓ Peer-reviewed Risk factors Medical Care

Key finding: memantine, cholinesterase inhibitor (ChEI), antipsychotic use] estimated adjusted odds ratios (aOR) and 95% CIs for resident, facility, and HRR characteristics. +4 more findings

• Treatments
• Side Effects
• Care Services

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A multimodal machine learning model for predicting dementia conversion in Alzheimer’s disease

53/100 ✓ Peer-reviewed Health systems and care delivery Scientific Reports

Key finding: As a result of testing the robustness of the model, the GBM model was the most stable, and in modality combination, model performance was further improved in the absence of T2-FLAIR image features.

• Early Stage
• Digital Tools

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Cholinesterase inhibitors and memantine are associated with a reduced mortality in nursing home residents with dementia: a longitudinal observational study

61/100 ✓ Peer-reviewed Treatments Alzheimer's Research & Therapy

Key finding: The use of conventional anti-dementia drugs is associated with a lower mortality in nursing home residents with dementia and should be widely used in this population. +3 more findings

• Treatments
• Care Services

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Environmental pollution and extreme weather conditions: insights into the effect on mental health

43/100 ✓ Peer-reviewed Risk factors Frontiers in psychiatry

Key finding: However, the knowledge about possible psychiatric disorders associated with these exposures is currently not well disseminated. +3 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Physical exercise, cognition, and brain health in aging

71/100 ✓ Peer-reviewed Prevention trials Trends in neurosciences

Key finding: We conclude by highlighting goals for future studies, including addressing unexplored neurobiological mechanisms and the inclusion of under-represented populations.

• Lifestyle

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An immersive virtual reality shopping task detects declines in instrumental activities of daily living in individuals with Parkinson's disease

39/100 ✓ Peer-reviewed Risk factors Parkinsonism & Related Disorders

Key finding: There were no between-group differences in traditional performance measures of motor, cognitive, or IADL function. +4 more findings

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The Association of Ancillary Diagnostic Tests With Outcome in Dementia

50/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: Patients who underwent CSF testing or PET/SPECT had higher mean total health care costs as compared to controls (CSF €248, 95% CI 64-433; PET/SPECT: €315, 95% CI 179-451). +2 more findings

• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes

63/100 ✓ Peer-reviewed Genetics eLife

Key finding: Compared to traditional approaches, BADGERS uses GWAS summary statistics as input and does not require multiple traits to be measured in the same cohort. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice

43/100 ✓ Peer-reviewed Biomarkers FEBS letters

Key finding: These findings suggest that the decline in glutathione levels, due to aging or AD pathology, may contribute to the progression of AD.

• Brain Biology

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A Data-Driven Approach to Defining Risk-Adjusted Coding Specificity Metrics for a Large U.S. Dementia Patient Cohort

43/100 ✓ Peer-reviewed Health systems and care delivery Healthcare (Basel, Switzerland)

Key finding: Inadequate coding specificity can have significant consequences at administrative and patient levels. +2 more findings

• Care Services

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Alzheimer's disease and its treatment-yesterday, today, and tomorrow

51/100 ✓ Peer-reviewed Drug development Frontiers in pharmacology

Key finding: AD is a multi-factorial neurodegenerative disorder with familial, life style and comorbidity influences impacting a global population of more than 47 million with a projected escalation by 2050 to exceed 130 million. +3 more findings

• Treatments

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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model

46/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: In APPL/S mice, BD10-2 treatment improved memory and LTP deficits. +4 more findings

• Brain Biology

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Hearing Loss and Cognitive Decline in the Aging Population: Emerging Perspectives in Audiology

43/100 ✓ Peer-reviewed Risk factors Audiology research

Key finding: Highlighting the evolving significance of audiologists in the dual management of cognitive health and hearing impairments, the author focuses on their role in identifying early signs of cognitive impairment and evaluates various cognitive screening tools used in this context. +4 more findings

• Risk Factors
• Diagnosis

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Adult-onset hearing loss and incident cognitive impairment and dementia - A systematic review and meta-analysis of cohort studies

89/100 ✓ Peer-reviewed Risk factors Ageing research reviews

Key finding: We identified fifty studies (N=1,548,754). +4 more findings

• Risk Factors

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Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly

69/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: Aβ-PET was abnormal in 81 participants from J-TRC and 71 participants from BioFINDER. +1 more finding

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease

51/100 ✓ Peer-reviewed Tau biomarkers Annals of neurology

Key finding: Irisin, released by muscles during exercise, was recently identified as a neuroprotective factor in mouse models of Alzheimer disease (AD). +3 more findings

• Biomarkers

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Distinct roles of TREM2 in central nervous system cancers and peripheral cancers

48/100 ✓ Peer-reviewed TREM2 and immune genetics Cancer cell

Key finding: Whether myeloid cell-directed therapeutic targets identified in peripheral non-CNS cancers are applicable to GBM requires further study. +3 more findings

• Genetics

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Drug repurposing for neurodegenerative diseases

43/100 ✓ Peer-reviewed Drug development Progress in molecular biology and translational science

Key finding: Neurodegenerative diseases (NDDs) are neuronal problems that include the brain and spinal cord and result in loss of sensory and motor dysfunction. +2 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source