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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

We observed a nonlinear trajectory of two functional connectivity metrics-temporal variability (fluidity) and connectedness (average node strength)-across symptom severity, especially in the delta frequency band. Both measures (F(2,123) = 1.86, p =.037; F(2,123) = 1.51, p =.023, respectively) were elevated in the intermediate severity groups-that is, in CN-CCF and possible MCI-LB (i.e., one core clinical feature)-and this was associated with better executive functioning after controlling for age and premorbid intelligence (rho = 0.26, p =.004; rho = 0.28, p =.002, respectively). Fluidity was further associated with right caudal locus coeruleus integrity, particularly among individuals with lower premorbid intelligence (F(5,97) = 3.56, p =.005). Our findings indicate that increased dynamic reconfiguration and enhanced connectivity may serve compensatory functions in early DLB, helping temporarily preserve cognition.

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APA 7th

Mitterová, K., Výtvarová, E., Kovářová, A., Lamoš, M., Fousek, J., & Rektorová, I. (2025). Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01828-1

Vancouver

Mitterová K, Výtvarová E, Kovářová A, Lamoš M, Fousek J, Rektorová I. Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-025-01828-1. PMID: 40849483.

BibTeX

@article{mitterova2025-40849483,
  author  = {Mitterová, Kristína and Výtvarová, Eva and Kovářová, Anežka and Lamoš, Martin and Fousek, Jan and Rektorová, Irena},
  title   = {{Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01828-1},
  pmid    = {40849483},
  url     = {https://doi.org/10.1186/s13195-025-01828-1}
}

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Key findings

We observed a nonlinear trajectory of two functional connectivity metrics-temporal variability (fluidity) and connectedness (average node strength)-across symptom severity, especially in the delta frequency band.
Both measures (F(2,123) = 1.86, p =.037; F(2,123) = 1.51, p =.023, respectively) were elevated in the intermediate severity groups-that is, in CN-CCF and possible MCI-LB (i.e., one core clinical feature)-and this was associated with better executive functioning after controlling for age and premorbid intelligence (rho = 0.26, p =.004; rho = 0.28, p =.002, respectively).
Fluidity was further associated with right caudal locus coeruleus integrity, particularly among individuals with lower premorbid intelligence (F(5,97) = 3.56, p =.005).
Our findings indicate that increased dynamic reconfiguration and enhanced connectivity may serve compensatory functions in early DLB, helping temporarily preserve cognition.

Why it matters

This study found that two functional connectivity measures were elevated in intermediate severity groups in early Lewy body dementia and were associated with better executive functioning, suggesting a possible compensatory role. It is about early brain changes and compensation, not about treating, curing or preventing the disease.

Study details

Participants39
Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy)
Journal's citation record	1 / 4	Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	39 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Irena Rektorová: h-index 50 (OpenAlex, whole career)
Institution's track record	0 / 3	Masaryk University: institution h-index 423 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40849483)
Free to read	2 / 2	Free to read
Total	42 / 100	—

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