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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

Objective To examine if immune cell changes are present in early stages of Dementia with Lewy Bodies (DLB). Background Evidence for inflammation in synucleinopathies has been building. An extensive number of studies have documented inflammatory changes in Parkinson’s disease (PD), but much less is known about DLB. Post-mortem DLB brains show T-cell infiltration, and flow cytometry and cytokine/chemokine measures in DLB subjects have suggested the presence of inflammatory responses in DLB. However, there is limited understanding if immune cell changes are present at the earliest stages of DLB. Methods We recruited a small, exploratory cohort of nine subjects with Mild Cognitive Impairment—Lewy Bodies (MCI-LB) as part of the broader Alabama Udall cohort study, which is focused on the role of inflammation in early PD. The MCI-LB cohort was compared to subjects with de novo PD (n = 64) and healthy controls (n = 70) from the larger Alabama Udall cohort. Subjects underwent clinical assessments, including Movement Disorder Society-United Parkinson’s Disease rating scale (MDS-UPDRS), and comprehensive cognitive assessment. Blood was obtained for flow cytometry and cytokine/chemokine analyses. Results Demographics and medical history were comparable between groups. Significant differences in University of Pennsylvania Smell Identification Test, Schwab and England Activities of Daily Living, and MDS-UPDRS scores were observed between the groups. MCI-LB subjects had poorer cognitive composite scores compared to PD participants. MCI-LB subjects demonstrated a robust 60% reduction in mature neutrophils compared to healthy controls. Conclusion Our data show changes in innate immune cells in MCI-LB compared to healthy controls in this small exploratory study. A larger cohort study is needed to validate these findings.

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APA 7th

Yacoubian, T. A., Qin, H., Amara, A. W., Stover, N. P., Ruffrage, L., Zhang, Y., et al. (2025). Inflammatory changes in early dementia with Lewy bodies. Frontiers in Neurology. https://doi.org/10.3389/fneur.2025.1640614

Vancouver

Yacoubian TA, Qin H, Amara AW, Stover NP, Ruffrage L, Zhang Y, et al. Inflammatory changes in early dementia with Lewy bodies. Frontiers in Neurology. 2025. doi:10.3389/fneur.2025.1640614. PMID: 40933044.

BibTeX

@article{yacoubian2025-40933044,
  author  = {Yacoubian, Talene A. and Qin, Hongwei and Amara, Amy W. and Stover, Natividad P. and Ruffrage, Lauren and Zhang, Yue and Kennedy, Richard and Geldmacher, David and others},
  title   = {{Inflammatory changes in early dementia with Lewy bodies}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1640614},
  pmid    = {40933044},
  url     = {https://doi.org/10.3389/fneur.2025.1640614}
}

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Key findings

The MCI-LB cohort was compared to subjects with de novo PD (n = 64) and healthy controls (n = 70) from the larger Alabama Udall cohort.
Results Demographics and medical history were comparable between groups.
Significant differences in University of Pennsylvania Smell Identification Test, Schwab and England Activities of Daily Living, and MDS-UPDRS scores were observed between the groups.
MCI-LB subjects had poorer cognitive composite scores compared to PD participants.
MCI-LB subjects demonstrated a robust 60% reduction in mature neutrophils compared to healthy controls.

Why it matters

In a small exploratory cohort, immune cell changes were examined in early dementia with Lewy bodies compared to Parkinson's disease and healthy controls. This is early preliminary work and does not provide a treatment, cure, or prevention for Alzheimer's disease.

New to this subject? Start with our plain-English guide: Getting a diagnosis →

Study details

Study designcohort study
Participants64
Evidence strengthModerate

How this study scored 47/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in Neurology)
Journal's citation record	2 / 4	Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	64 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Etty N. Benveniste: h-index 89 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Alabama at Birmingham: institution h-index 1,118 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40933044)
Free to read	2 / 2	Free to read
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

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