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Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia
Claudia Bartels, J. Chen, Michael K. Belz, Renat Yakupov, Emrah Düzel, Wenzel Glanz, Falk Lüsebrink, Peter Dechent et al.. Alzheimer s Research & Therapy, 2025-08-22
Topic: Risk, prevention and care in population studies
Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865). Moderate associations of the FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019), in addition to the left C3 body were observed (r = 0.525, p = 0.002). LTR may constitute a potential indicator of memory circuitry integrity in older adults, which is also mirrored by its association with CA1 volume. Thus, assessment of LTR and associated neural circuits may help to better identify individuals at risk for future cognitive decline today indistinguishable from HC, ultimately paving the way for early intervention.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bartels, C., Chen, J., Belz, M. K., Yakupov, R., Düzel, E., Glanz, W., et al. (2025). Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia. Alzheimer s Research & Therapy. https://doi.org/10.1186/s13195-025-01833-4
Vancouver
Bartels C, Chen J, Belz MK, Yakupov R, Düzel E, Glanz W, et al. Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia. Alzheimer s Research & Therapy. 2025. doi:10.1186/s13195-025-01833-4. PMID: 40847320.
BibTeX
@article{bartels2025-40847320,
author = {Bartels, Claudia and Chen, J. and Belz, Michael K. and Yakupov, Renat and Düzel, Emrah and Glanz, Wenzel and Lüsebrink, Falk and Dechent, Peter and others},
title = {{Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia}},
journal = {Alzheimer s Research \& Therapy},
year = {2025},
doi = {10.1186/s13195-025-01833-4},
pmid = {40847320},
url = {https://doi.org/10.1186/s13195-025-01833-4}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Only FCSRT-IR LTR rates sufficiently differentiated SCD from HC (AUC of 0.701; 95% CI 0.537-0.865).
- Moderate associations of the FCSRT-IR LTR rate with CA1 bodies in both hemispheres (left CA1 body r = 0.419, p = 0.017; right: r = 0.412, p = 0.019), in addition to the left C3 body were observed (r = 0.525, p = 0.002).
- LTR may constitute a potential indicator of memory circuitry integrity in older adults, which is also mirrored by its association with CA1 volume.
- Thus, assessment of LTR and associated neural circuits may help to better identify individuals at risk for future cognitive decline today indistinguishable from HC, ultimately paving the way for early intervention.
Why it matters
This study found that a long-term retrieval measure from the FCSRT-IR differentiated subjective cognitive decline from healthy controls and was moderately associated with CA1 hippocampal volume. The authors suggest this measure and its related brain circuits may help identify people at risk for future cognitive decline, but it is a marker study and does not test treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s Research & Therapy) |
| Journal's citation record | 1 / 4 | Alzheimer s Research & Therapy: journal h-index 146 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 7 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Roberto Goya‐Maldonado: h-index 30 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Bonn: institution h-index 1,072 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40847320) |
| Free to read | 2 / 2 | Free to read |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/s13195-025-01833-4
- PubMed: 40847320
- Original source →
- Free full text: Alzheimer s Research & Therapy →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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