Newest studies

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines

62/100 ✓ Peer-reviewed Prevention trials Nutrition Reviews

Key finding: The MD is a scientifically supported dietary intervention with broad preventive and therapeutic benefits. +1 more finding

• Lifestyle

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Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease

42/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of Controlled Release

Key finding: Whereas neurotoxic Aβ is derived from amyloid precursor protein (APP) by β- and γ-secretase cleavage, APP processing along the non-amyloidogenic pathway results in the secretion of the large neurotrophic ectodomain APPsα. +1 more finding

• Treatments
• Brain Biology

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International Menopause Society (IMS) recommendations and key messages on women’s midlife health and menopause

65/100 ✓ Peer-reviewed Risk factors Climacteric

Key finding: Overall, 342 recommendations (285 supported by research data and 57 good practice points) and 40 key messages have been formulated. +1 more finding

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Putaminal hypermetabolism identifies Lewy body co-pathology in Alzheimer's disease

46/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Compared to ADSAA-, ADSAA+ showed putamen SRP hypermetabolism and middle occipital gyrus (MOG) SUVR hypometabolism. +4 more findings

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Eligibility for lecanemab and donanemab in Korea under Appropriate Use Recommendations

61/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Among 1005 amyloid-positive participants, 24.6% were eligible for lecanemab and 28.0% for donanemab (9.1% and 10.3% of the initial sample). +4 more findings

• Treatments

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Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease

75/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Plasma pTau217R matched CSF eMTBR-tau243 and outperformed MTBR-tau243. +4 more findings

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Inhibition of Acyl-CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low-density lipoprotein receptor 1 (LRP1)-dependent phagocytosis of amyloid beta protein in microglia

46/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: ACAT1 inhibition increased LRP1 levels and soluble TREM2 (sTREM2) release via enhanced TREM2 cleavage by ADAM metallopeptidase domain 10/17 (ADAM10/17). +4 more findings

• Brain Biology
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Shared genes and pathways in dementia: Insights from genome-wide association studies

46/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction

59/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Known and novel signals were identified via G/T/PWAS. +4 more findings

• Genetics

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Blood biomarkers of Alzheimer's disease: Balancing clinical relevance with improved accessibility and sustainability

43/100 ✓ Peer-reviewed Biomarkers Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Key finding: Indeed, AD-BBMs are likely to be more cost-effective in the long term and conservative calculations performed here suggest that they would have an approx. 10-fold and 36-fold lower carbon footprint compared to cerebrospinal fluid (CSF) lumbar punctures and amyloid positron emission tomography (PET) scans, respectively.

• Biomarkers

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Increased neuroplastic activity in the pathogenesis of Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Higher GAP-43 was cross-sectionally related to all AD biomarkers (p-values < 0.0001) and predicted longitudinal reductions in Aβ42 (p < 0.0001). +4 more findings

• Biomarkers

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In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217

55/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: aECAD was associated with significantly worse scores in processing speed (β = -0.19, p = 0.004) and executive function (β = -0.20, p = 0.009) domains after controlling for age, sex, education, race, and ethnicity. +2 more findings

• Biomarkers

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Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change

71/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The Core 1 biomarker PGSs predicted AD pathology and associated cognitive performance better than the AD PGSs in both populations. +4 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Genetic and environmental contributions to variation in plasma phosphorylated tau 217

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Genetic contributions accounted for 42% (males) and 41% (females) of variance in p-tau217. +4 more findings

• Biomarkers
• Genetics

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Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies

77/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The cohorts had low pre-test probability (%Aβ positivity = 14.9-24.7) and were predominantly cognitively normal (> 73%). +4 more findings

• Biomarkers
• Early Stage

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AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy

45/100 ✓ Peer-reviewed Drug development CNS neuroscience & therapeutics

Key finding: The AMPK/SIRT1/PGC-1α pathway represents a cornerstone target at the intersection of metabolism, aging, and disease.

• Treatments
• Brain Biology
• Policy

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Impact of Statin Therapy on the Risk of Stroke Recurrence, Mortality, and Dementia After Ischemic Stroke (ISMARDD Study): A Comprehensive Meta-Analysis

41/100 ✓ Peer-reviewed Vascular contributions Neurology International

Key finding: all-cause mortality, stroke recurrence, cognition, and C-reactive protein (CRP). +4 more findings

• Treatments
• Risk Factors

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Neighborhood deprivation and midlife cognition: Evidence of a modifiable vascular pathway involving health behaviors and cerebral small vessel disease

41/100 ✓ Peer-reviewed Vascular contributions Alzheimer s & Dementia

Key finding: Neighborhood deprivation was associated with poorer cognition (r = 0.36, p < 0.001), greater prevalence of modifiable risk factors (r = 0.36, p < 0.001), and greater SVD burden (β = 0.18, p = 0.008). +3 more findings

• Other Dementias
• Risk Factors
• Prevention

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Advances in Intervention Strategies for Advance Care Planning in Dementia Patients

27/100 ✓ Peer-reviewed End-of-life care DOAJ (DOAJ: Directory of Open Access Journals)

Key finding: This review found that existing studies demonstrated the benefits of advance care planning in dementia patients; the intervention strategies were mostly based on face-to-face structured discussions about the understanding of disease, future goals of care, and care preferences of dementia patients, and the intervention considerations mainly included the timing of implementation, assessment of the decision-making capacity of dementia patients, promotion of family involvement, and training of the intervention implementer. +1 more finding

• End-of-Life Care

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Predicting hospice eligibility among dementia patients using language models

45/100 ✓ Peer-reviewed End-of-life care Alzheimer s & Dementia

Key finding: Of 9872 individuals, 3563 (36%) died within 6 months. +4 more findings

• End-of-Life Care

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Identifying triggers for optimal timing of advance care planning in electronic primary health care records: a nested case-control study

53/100 ✓ Peer-reviewed End-of-life care BMJ Open

Key finding: We included 17098 records, 4139 from deceased individuals (mean age 81) and 12959 from living individuals (mean age 79). +3 more findings

• End-of-Life Care

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Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation

60/100 ✓ Peer-reviewed Clinical safety American Journal of Critical Care

Key finding: Clinical characteristics and demographics were similar between groups. +4 more findings

• Clinical Trials

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Identifying dementia risk profiles for targeted interventions: A latent class analysis of at‐risk middle‐aged Australians

47/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

Key finding: Among 403 participants (mean age 56.4 ± 5.7 years, 62.5% female), the median number of dementia risk factors was 5.0; hyperlipidaemia (92.5%), low cognitive activity (72.5%), obesity (57.6%), and hypertension (52.7%) were the most prevalent. +4 more findings

• Risk Factors
• Prevention

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Efficacy of a multidomain intervention in older adults with vascular risks: The Japan‐Multimodal Intervention Trial for the Prevention of Dementia (J‐MINT)

38/100 ✓ Peer-reviewed Prevention trials Alzheimer s & Dementia

Key finding: Among the participants, 298 had at least one untreated or uncontrolled VRF. +4 more findings

• Clinical Trials
• Prevention
• Risk Factors

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Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study

44/100 ✓ Peer-reviewed Disease mechanisms BMJ Open

Key finding: 180 patients (46 %) developed delirium and 70% of these had dementia. +4 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source