Newest studies

The impact of moxibustion on brain function in vascular dementia: a neuroimaging study involving amplitude of low-frequency fluctuations and functional connectivity

32/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neurology

Key finding: Object On the basis of determining the clinical effect of moxibustion on vascular dementia (VD), this study explored the central mechanism of moxibustion on VD through fMRI. +1 more finding

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Wearable Sensor Technologies and Gait Analysis for Early Detection of Dementia: Trends and Future Directions

50/100 ✓ Peer-reviewed Digital health tools Sensors

Key finding: Despite the proliferation of research, significant gaps persist in longitudinal validation, methodological standardization, and integration into clinical workflows.

• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Emerging therapies targeting lipoprotein(a): the next frontier in cardiovascular risk reduction

35/100 ✓ Peer-reviewed Prevention and risk Frontiers in Medicine

Key finding: The Lp(a) particle is enriched with oxidized phospholipids (OxPLs), which confer enhanced atherogenic and pro-inflammatory properties compared with low-density lipoprotein (LDL). +3 more findings

• Prevention
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Impact of Triplicated DYRK1A on Neurogenesis and Intellectual Disability in Down Syndrome and Therapeutic Potential

28/100 ✓ Peer-reviewed Genetics Gene Expression

Key finding: Full or partial trisomy of human chromosome 21 results in dysregulation of gene expression, leading to the manifestation of specific phenotypes described in individuals with Down syndrome (DS). +2 more findings

• Genetics
• Treatments
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Antidepressant Use at the Threshold: using electronic health records to characterise people prescribed antidepressants around the time of dementia diagnosis

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: The high incidence of new prescribing, as well as the lack of deprescribing, points to unmet needs and a role for more proactive medication review. +2 more findings

• Diagnosis

Scored 32 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease

16/100 ⚠ Preprint — not yet peer-reviewed Genetics bioRxiv : the preprint server for biology

Key finding: Along the remodeling axis, fibroblasts showed ECM alterations, while epithelial and stromal cells demonstrated aberrant cell-matrix adhesion pathways. +2 more findings

Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Plasma p-Tau217 and GFAP predict widespread cognitive decline in Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers Journal of neurology

Key finding: Elevated CSF p-Tau181 and NfL levels were associated with greater decline in memory and executive function. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Deposition of aggregated cystatin C-amyloid-β complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis

32/100 ✓ Peer-reviewed Brain tissue and pathology Journal of Neuropathology & Experimental Neurology

Key finding: In AD brains, immunohistochemistry revealed Aβ positivity around cortical and leptomeningeal vessels as well as in intra- and extracellular areas. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Deep cervical lymphatic-venous anastomosis in dementia: a clinical and mechanistic evaluation

44/100 ✓ Peer-reviewed Cognitive tests and assessment International Journal of Surgery

Key finding: Within one week after dcLVA, 64.3% of patients demonstrated MMSE improvement, with further functional gains observed in continence, emotional regulation, motor coordination, and feeding independence. +4 more findings

Full summary, score breakdown and related studies → Original source

Prevalence of Alzheimer’s disease pathology in the community

61/100 ✓ Peer-reviewed How common it is Nature

Key finding: Our findings suggest a higher prevalence of Alzheimer’s disease dementia in older individuals and a lower prevalence of preclinical Alzheimer’s disease in younger groups than previously estimated 2 .

• Early Stage

Full summary, score breakdown and related studies → Original source

Telemedicine in the Care of Older Adults with Dementia: Caregivers’ Perceptions and Experiences

31/100 ✓ Peer-reviewed Caregiving Geriatrics

Key finding: Caregivers considered telemedicine useful, accessible, and safe, facilitating the continuity of care and strengthening the caregiver–professional relationship. +4 more findings

• Caregiving
• Digital Tools

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Prevalence of dementia and mild cognitive impairment in the Mexican population: evidence from Mex-Cog, a harmonized cognitive assessment protocol study

45/100 ✓ Peer-reviewed Getting a diagnosis The Journals of Gerontology Series B

Key finding: We estimated the prevalence of dementia at 6.7% [95% confidence interval (CI): 5.4-8.0] and MCI at 10% (95% CI: 8.7-11.7). +4 more findings

• Diagnosis
• Early Stage

Full summary, score breakdown and related studies → Original source

Investigating the factor structure of the Montreal Cognitive Assessment: a qualitative review

37/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Psychology

Key finding: Across CTT studies, findings ranged from two-factor to hierarchical multi-factor models, with a general cognitive factor frequently emerging. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Alzheimer-related individual factors modulate effects of transcranial direct current stimulation strength on white matter integrity in mild cognitive impairment

45/100 ✓ Peer-reviewed Genetics Scientific Reports

Key finding: Higher EF strength was significantly associated with increased FA and reduced MD and RD in specific left-lateralized tracts, including the anterior thalamic radiation, corticospinal tract, inferior fronto-occipital fasciculus, and inferior longitudinal fasciculus. +3 more findings

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associations and Peripheral Clues for Biological Mechanisms

48/100 ✓ Peer-reviewed Genetics Journal of the American Heart Association

Key finding: Stroke interacts with APOE ε4 to influence dementia, with the association being more pronounced in APOE ε4 non‐carriers. +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Multi-dimensional attention framework for personalized Alzheimer’s disease progression prediction across sporadic and genetic risk cohorts

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's medRxiv

Key finding: Here we present a multi-dimensional attention framework that simultaneously captures temporal dynamics and biomarker importance patterns to predict disease progression across three fundamentally different populations: the general late-onset population using the Alzheimer’s Disease Prediction Of Longitudinal Evolution (TADPOLE) dataset (N=1669), cases with Down Syndrome-associated Alzheimer’s disease using the Alzheimer’s Biomarker Consortium - Down Syndrome (ABC-DS) dataset (N=396) and cases with autosomal dominant Alzheimer’s disease using the Dominantly Inherited Alzheimer Network (DIAN) dataset (N=425). +3 more findings

• Genetics

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

FDA approval of the Lumipulse G pTau217/β-amyloid 1-42 plasma ratio test: a new era in accessible Alzheimer's diagnosis

42/100 ✓ Peer-reviewed Getting a diagnosis Annals of Medicine and Surgery

Key finding: FDA cleared the Lumipulse G pTau217/Abeta1-42 plasma ratio test on May 16, 2025 for symptomatic adults 55+ +3 more findings

• Diagnosis
• Biomarkers
• Treatments

Full summary, score breakdown and related studies → Original source

MRI measures of cortical microstructural damage associate with tau accumulation in presymptomatic Alzheimer’s disease

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: NODDI-derived ODI is associated with tau PET signal, even in preclinical disease and may discriminate individuals with-and without tau beyond the MTL. +2 more findings

• Brain Scans
• Treatments

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4

43/100 ✓ Peer-reviewed Genetics Genes

Key finding: Based on the folding energy (ΔΔG) calculations, mutations G165W and L155W were particularly destabilizing in APOE4. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Serum albumin combined with mFI-5 for predicting postoperative delirium in elderly patients with hip fracture

31/100 ✓ Peer-reviewed Clinical safety Microchemical Journal

Key finding: It not only prolongs hospital stays and increases medical expenses, but is also closely related to poor functional recovery, long-term cognitive decline, increased risk of dementia and rising mortality. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein

44/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: Epidemiological studies suggest that higher MedDiet adherence is associated with slower cognitive decline, reduced conversion from mild cognitive impairment to Alzheimer’s disease, and better motor and non-motor outcomes in Parkinson’s disease. +4 more findings

• Lifestyle
• Brain Biology

Full summary, score breakdown and related studies → Original source

Tau protein: Physiological functions and multifaceted roles in neurodegenerative and psychiatric disorders

36/100 ✓ Peer-reviewed Disease mechanisms Genomic psychiatry :

Key finding: Dysfunction of tau, caused by mutations, hyperphosphorylation, aggregation, or reduced expression, is closely associated with tauopathies (e.g., Alzheimer disease) and psychiatric disorders. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study

57/100 ✓ Peer-reviewed Risk factors The Journal of Clinical Endocrinology & Metabolism

Key finding: In a meta-analysis of 2 one-sample MR studies, the odds ratio (OR) for 1-SD higher BMI in predicting vascular-related dementia was 1.63 (95% CI, 1.13-2.35). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Ophthalmic imaging and artificial intelligence in early diagnosis of Alzheimer disease

27/100 ✓ Peer-reviewed Brain scans and imaging Neurology Bulletin

Key finding: It also addresses methodological limitations and implementation challenges—including variability of results, insufficient specificity, and the black-box nature of artificial intelligence.

• Brain Scans
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Can objective measures of physical activity and sleep serve as early predictors of dementia among individuals with cognitive impairment?

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: The MCI group had the most surprising findings—although they were cognitively similar to the control group, they were less physically active than the AD group and had the worst sleep efficiency. +2 more findings

• Lifestyle
• Digital Tools

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source